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Antipain, dihydrochloride

Antipain, dihydrochloride Structure
Antipain, dihydrochloride structure
CAS No.
37682-72-7
Chemical Name:
Antipain, dihydrochloride
Synonyms
ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl
CBNumber:
CB1279463
Molecular Formula:
C27H46Cl2N10O6
Molecular Weight:
677.62
MDL Number:
MFCD00135957
MOL File:
37682-72-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:49:08
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Antipain, dihydrochloride Properties

Melting point 209-217 °C
Boiling point 652.92°C (rough estimate)
Density 1.2423 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. -20°C
solubility H2O: 50 mg/mL
form White powder
color White
biological source Streptomyces sp.
Water Solubility 0.01M in water
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
InChIKey YAHXZYICKJUJEO-BXLPLHKWSA-N
SMILES Cl[H].Cl[H].[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)NC(Cc1ccccc1)C(O)=O)C(C)C
FDA UNII GWZ8LOU6OG
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Precautionary statements  P261-P271-P280
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
RTECS  YV9350800
F  1-10
HS Code  2934999090
Storage Class 11 - Combustible Solids

Antipain, dihydrochloride price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 178220 Antipain, Hydrochloride 37682-72-7 5mg $94.1 2026-04-30 Buy
Sigma-Aldrich 178220 Antipain, Hydrochloride 37682-72-7 10mg $160 2026-04-30 Buy
Sigma-Aldrich 11004646001 Antipain dihydrochloride 37682-72-7 10mg $267 2026-04-30 Buy
Cayman Chemical 26705 Antipain (hydrochloride) ≥95% 37682-72-7 5mg $48 2026-04-30 Buy
Cayman Chemical 26705 Antipain (hydrochloride) ≥95% 37682-72-7 10mg $90 2026-04-30 Buy
Product number Packaging Price Buy
178220 5mg $94.1 Buy
178220 10mg $160 Buy
11004646001 10mg $267 Buy
26705 5mg $48 Buy
26705 10mg $90 Buy

Antipain, dihydrochloride Chemical Properties, Uses, Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

in vivo

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

References

[1] UMEZAWA H. Structures and activities of protease inhibitors of microbial origin.[J]. Methods in enzymology, 1976, 45: 678-695. DOI:10.1016/s0076-6879(76)45058-9
[2] T GOTOH. Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors.[J]. Journal of bioscience and bioengineering, 2001, 92 3: 248-255. DOI:10.1263/jbb.92.248
[3] K. HOCKENSMITH. Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia[J]. Microbial pathogenesis, 2016, 100: Pages 37-42. DOI:10.1016/j.micpath.2016.08.041
[4] AMIN N M. Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.[J]. Tropical biomedicine, 2004, 21 2: 57-60.
[5] YUJI MORIYASU  Yuko I. Use of protease inhibitors for detecting autophagy in plants.[J]. Methods in enzymology, 2008, 451: 557-580. DOI:10.1016/s0076-6879(08)03232-1

Antipain, dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Antipain, dihydrochloride Suppliers

Global Suppliers ( 144)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Shanghai JONLN Reagent Co., Ltd. 400-0066400 13621662912 422131432@qq.com China 9970 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
GL Biochem (Shanghai) Ltd 64
Syntechem Co.,Ltd 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Beijing HuaMeiHuLiBiological Chemical 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai BeiZhuo Biotech Co., Ltd. 50
Shanghai JONLN Reagent Co., Ltd. 55

View Latest Price from Antipain, dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Antipain dihydrochloride pictures 2026-07-15 Antipain dihydrochloride
37682-72-7
 $69.00 95.00% 10g TargetMol Chemicals Inc.

37682-72-7 (Antipain, dihydrochloride) Related Search:

D-Amino acid oxidase α-Chymotrypsin Pectinase Acetyl coenzyme A sodium salt HEXOKINASE
alpha-Amylase PROTEASE α-Amylase EC 2.6.1.2 Pepsin
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Antipain hydrochloride dihydrate Antipain, dihydrochloride Antipain monohydrochloride dihydrate

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ANTIPAIN (2HCL) ANTIPAIN HYDROCHLORIDE [(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL [(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE (S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-( ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride antipain dihydrochloride from microbial source n-(nα-carbonyl-arg-val-arg-al)-phe N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2) Antipain 2HCI L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride Phe-Arg-Val-Arg-CHO.2HCl ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL (9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2) EZNA KIT ISOLATION FFPE RNA Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem Antipain dihydrochloride from microbial source protease inhibitor Antipain HCl BDBM 32804 BDBM32804 BDBM-32804 BDBM 32804, Antipain Antipain 2HCl|||BDBM-32804|||BDBM 32804, Antipain|||BDBM32804 TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS L-Valimide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2) ANTIPAIN Antipain, dihydrochloride 37682-72-7 C27H44N10O62HCl C27H44N10O62ClH C27H46Cl2N10O6 BioChemical Biochemicals and Reagents Antibiotics Analytical Enzymes Antibiotics A to Z Antibiotics A-F Enzymes, Inhibitors, and Substrates Trypsin Inhibitors peptides inhibitor AN-AZ Antineoplastic and Immunosuppressive Antibiotics Broad Spectrum Inhibitors of Proteolytic Enzyme Classes Cathepsin D