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ChemicalBook >> CAS DataBase List >>RO-31-7549

RO-31-7549

RO-31-7549 Structure
RO-31-7549 structure
CAS No.
125313-65-7
Chemical Name:
RO-31-7549
Synonyms
Bisindolylmaleimide VIII;Bis VIII;RO-31-7549;RO 31-7549 ACETATE SALT;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Bisindolylmaleimide VIII/Ro 31-7549;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
CBNumber:
CB1281637
Molecular Formula:
C24H22N4O2
Molecular Weight:
398.46
MDL Number:
MFCD00909467
MOL File:
125313-65-7.mol
MSDS File:
SDS
Last updated:2026-04-27 11:50:38
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RO-31-7549 Properties

storage temp. −20°C
solubility DMSO: soluble
form Red to reddish-orange solid
color red to red-orange
InChI 1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
InChIKey UQHKJRCFSLMWIA-UHFFFAOYSA-N
SMILES N1C(=O)C(=C(C1=O)c4c5c([n](c4)C)cccc5)c2c3c([n](c2)CCCN)cccc3
FDA UNII Y6197FQK8I
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

RO-31-7549 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557508 Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. 		125313-65-7 1mg $202 2026-04-30 Buy
ACHEMBLOCK AD265348 Bisindolylmaleimide VIII 98% 125313-65-7 1MG $350 2026-05-27 Buy
ACHEMBLOCK AD265348 Bisindolylmaleimide VIII 98% 125313-65-7 5MG $865 2026-05-27 Buy
ACHEMBLOCK AD265348 Bisindolylmaleimide VIII 98% 125313-65-7 25MG $1820 2026-05-27 Buy
aablocks AA000NES 1H-Pyrrole-2,5-dione,3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)- 125313-65-7 1mg $255 2026-05-25 Buy
Product number Packaging Price Buy
557508 1mg $202 Buy
AD265348 1MG $350 Buy
AD265348 5MG $865 Buy
AD265348 25MG $1820 Buy
AA000NES 1mg $255 Buy

RO-31-7549 Chemical Properties, Uses, Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity.

General Description

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).

Biochem/physiol Actions

Cell permeable: yes

in vivo

Bisindolylmaleimide VIII (100 μg; i.p; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. With Bisindolylmaleimide VIII alone does not induce significant tumor regression[2].

Animal Model:6-8-week-old female NOD/SCID mice[2].
Dosage:100 μg
Administration:i.p.; every other day for three doses
Result:Resulted in nearly complete tumor regression combined toTRA-8.

IC 50

Rat Brain PKC: 158 nM (IC50); PKCα: 53 nM (IC50); PKC-βI: 195 nM (IC50); PKC-βII: 163 nM (IC50); PKCγ: 213 nM (IC50); PKCε: 175 nM (IC50)

RO-31-7549 Preparation Products And Raw materials

Raw materials

Preparation Products

RO-31-7549 Suppliers

Global Suppliers ( 52)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1363 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2934 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 7283 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky (shanghai) International Co.,Ltd 60
Sigma-Aldrich 80
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 58

View Latest Price from RO-31-7549 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bisindolylmaleimide VIII pictures 2026-04-27 Bisindolylmaleimide VIII
125313-65-7
 $293.00-987.00 97.54% 10g TargetMol Chemicals Inc.

RO-31-7549 Spectrum

RO-31-7549(125313-65-7)1HNMR

125313-65-7 (RO-31-7549) Related Search:

Ro 31-7549, immobilized Bisindolylmaleimide V RO 31-7549 ACETATE 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione 3-Isopropenyl-1-methyl-1H-pyrrole
RO-31-7549

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BISINDOLYLMALEIMIDE VIII ACETATE 1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)- 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE RO-31-7549 RO 31-7549 ACETATE SALT BIDINDOLYLMALEIMIDE VIII, ACETETE Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem Bisindolylmaleimide VIII Bisindolylmaleimide VIII/Ro 31-7549 Bis VIII 125313-65-7 C24H22N4O2C2H4O2 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators