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Bisindolylmaleimide VIII acetate salt

Bisindolylmaleimide VIII acetate salt structure

CAS No.: 138516-31-1

Chemical Name:: Bisindolylmaleimide VIII acetate salt

Synonyms: Bis VIII acetate;RO 31-7549 ACETATE;BISINDOLYLMALEIMIDE VIII ACETATE SALT;BisindolylMaleiMide VIII . AcOH [Ro 31-7549];Bisindolylmaleimide VIII acetate/138516-31-1;Bisindolylmaleimide VIII acetate, 10 mM in DMSO;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate;3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1);protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC

CBNumber:: CB32130296

Molecular Formula:: C24H22N4O2

Molecular Weight:: 398.464

MDL Number:: MFCD00909467

MOL File:: 138516-31-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
Bisindolylmaleimide VIII (acetate) ≥98%	13333	1mg	$55
Bisindolylmaleimide VIII (acetate) ≥98%	13333	5mg	$202
Bisindolylmaleimide VIII (acetate) ≥98%	13333	10mg	$376
Bisindolylmaleimide VIII Acetic Acid Salt	TRC-B448500-10MG	10mg	$244
Bisindolylmaleimide VIII Acetic Acid Salt	TRC-B448500-100MG	100mg	$1836

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Bisindolylmaleimide VIII acetate salt Properties

storage temp.	-20°C
solubility	Soluble in DMSO
form	Red powder.
color	Brown to reddish brown

SAFETY

Risk and Safety Statements

HS Code	2925199590

Bisindolylmaleimide VIII acetate salt price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13333	Bisindolylmaleimide VIII (acetate) ≥98%	138516-31-1	1mg	$55	2026-04-30	Buy
Cayman Chemical	13333	Bisindolylmaleimide VIII (acetate) ≥98%	138516-31-1	5mg	$202	2026-04-30	Buy
Cayman Chemical	13333	Bisindolylmaleimide VIII (acetate) ≥98%	138516-31-1	10mg	$376	2026-04-30	Buy
TRC	TRC-B448500-10MG	Bisindolylmaleimide VIII Acetic Acid Salt	138516-31-1	10mg	$244	2026-06-03	Buy
TRC	TRC-B448500-100MG	Bisindolylmaleimide VIII Acetic Acid Salt	138516-31-1	100mg	$1836	2026-06-03	Buy

Product number	Packaging	Price	Buy
13333	1mg	$55	Buy
13333	5mg	$202	Buy
13333	10mg	$376	Buy
TRC-B448500-10MG	10mg	$244	Buy
TRC-B448500-100MG	100mg	$1836	Buy

Bisindolylmaleimide VIII acetate salt Chemical Properties,Uses,Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.

Biological Activity

bisindolylmaleimide viii is a protein kinase c (pkc) inhibitor.the protein kinase c (pkc) consists of a family of closely related isoenzymes mediating various signal transduction processes. the ten isoenzymes that have been currently identified can be divided into three families on the basis of their different requirements for activation. members of the conventional pkc family are ca2+ and phospholipid-dependent and are activated by diacylglycerols and phorbol esters.

in vitro

previous study found that bisindolylmaleimides carrying a straight-chain alkyl side-chain bearing a cationic substituent, such as ro 31-7549 (bisindolylmaleimide viii) and ro 31-8220, showed a significant improvement in potency over the simple bisindolylmaleimides. for bisindolylmaleimide viii, a further improvement in potency was obtained by restricting the position of the amine substituent. moreove, unlike the indolocarbazole, staurosporine, which displayed 2-fold selectivity for pkc-β over the other examined isoenzymes, bisindolylmaleimide viii exhibited a slight selectivity for pkc-α over the other isoenzymes. compounds such as bisindolylmaleimide viii carrying a straight-chain alkyl side-chain with the cationic substituent were found to be equipotent as inhibitors of pkc-β, pkc-γ and pkc-ε [1].

in vivo

animal study found that, in neonatal rats, high glucose levels could induce the hypertrophy of cardiomyocytes. ro-31-8220, a analog of bisindolylmaleimide viii, was able to reverse the effect of high glucose on the cardiac myocytes,which might be through pkc/nf-κb/c-fos pathway [2].

IC 50

158 nm for rat brain pkc

References

[1] wilkinson, s. e.,parker, p.j. and nixon, j.s. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochemistry journal 294, 335-337 (1993).
[2] zhang, w. b. et al. reverse effect of protein kinase c inhibitor ro-31-8220 on the hypertrophy of cardiomyocytes of neonatal rats induced by high glucose levels. chinese journal of pathophysiology. 2009-08.

Bisindolylmaleimide VIII acetate salt Preparation Products And Raw materials

Raw materials

Preparation Products

Bisindolylmaleimide VIII acetate salt Suppliers

Global( 58)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53799	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7717	56
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62

Supplier	Advantage
TargetMol Chemicals Inc.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
J & K SCIENTIFIC LTD.	76
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62

View Lastest Price from Bisindolylmaleimide VIII acetate salt manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-15	Bisindolylmaleimide VIII acetate 138516-31-1	$39.00-149.00		99.27%	10g	TargetMol Chemicals Inc.
	2026-07-15	Bisindolylmaleimide VIII acetate 138516-31-1	$39.00-149.00		99.27%	10g	TargetMol Chemicals Inc.

Bisindolylmaleimide VIII acetate
138516-31-1
$39.00-149.00
99.27%
TargetMol Chemicals Inc.

Bisindolylmaleimide VIII acetate
138516-31-1
$39.00-149.00
99.27%
TargetMol Chemicals Inc.

Bisindolylmaleimide VIII acetate salt Spectrum

Bisindolylmaleimide VIII acetate salt(138516-31-1)¹HNMR

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1of4

BisindolylMaleiMide VIII . AcOH [Ro 31-7549] BISINDOLYLMALEIMIDE VIII ACETATE SALT RO 31-7549 ACETATE 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate Bis VIII acetate 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1) protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate Bisindolylmaleimide VIII acetate, 10 mM in DMSO Bisindolylmaleimide VIII acetate/138516-31-1 138516-31-1 inhibitor