Gambogic acid | 2752-65-0

Gambogic acid Properties

Melting point	88.5°C
Boiling point	586.06°C (rough estimate)
alpha	D20 -685° (methanol)
Density	1.1057 (rough estimate)
refractive index	1.5290 (estimate)
storage temp.	-20°C
solubility	DMSO: ≥10mg/mL
form	powder
pka	4.58±0.36(Predicted)
color	yellow to orange
Stability	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	GEZHEQNLKAOMCA-XKZIYDEJSA-N
SMILES	C(O)(=O)/C(/C)=C\C[C@]12C(=O)[C@]3([H])C=C4C(=O)C5=C(O[C@@]41[C@]([H])(C(C)(C)O2)C3)C(C/C=C(\C)/C)=C1O[C@](C)(CC/C=C(\C)/C)C=CC1=C5O \|&1:7,10,19,20,35,r\|
LogP	6.490 (est)
FDA UNII	8N585K83U2
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P310-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T

Risk Statements

25-36/37/38

Safety Statements

26-45

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

1

RTECS

PB9268200

HS Code

29189900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

LD50 unreported in mammal (species unspecified): 55mg/kg

NFPA 704

	0
2		0

Gambogic acid price More Price(83)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	345701	Gambogic acid	2752-65-0	25mg	$292	2026-04-30	Buy
Sigma-Aldrich	PHL80455	R,S-Gambogic acid phyproof^® Reference Substance		10 mg	$383	2025-07-31	Buy
Sigma-Aldrich	PHL80455	Gambogic acid phyproof Reference Substance	2752-65-0	10mg	$375	2024-03-01	Buy
Cayman Chemical	14761	Gambogic Acid ≥95%(mixtureofepimers)	2752-65-0	1mg	$37	2026-04-30	Buy
Cayman Chemical	14761	Gambogic Acid ≥95%(mixtureofepimers)	2752-65-0	5mg	$98	2026-04-30	Buy

Product number	Packaging	Price	Buy
345701	25mg	$292	Buy
PHL80455	10 mg	$383	Buy
PHL80455	10mg	$375	Buy
14761	1mg	$37	Buy
14761	5mg	$98	Buy

Gambogic acid Chemical Properties, Uses, Production

Description

Gambogic acid (2752-65-0) induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 mM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFb1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4

Chemical Properties

Yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the colloidal resin of Garcinia.

Uses

antiinflammatory, cytotoxic, inhibits HeLa cells in vitro;

Definition

ChEBI: A natural product found in Garcinia hanburyi.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC 50 value of 0.78-1.64 μ M and competitively inhibits antiapoptotic Bcl-2 family proteins (IC 50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μ M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks K IR 2.1 channels (EC 50 ≤ 100 nM).

Biochem/physiol Actions

Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.

Anticancer Research

Gambogic acid is a xanthonoid, also known as kokum that is a resin from Garciniaindica, that can inhibit the proliferation of human breast, hepatoma, lung, and gastriccarcinoma cells. It is also an apoptotic inducer and inhibits telomerase and theexpression of telomerase reverse transcriptase mRNA and its promoter. It also suppressesCDK7-mediated CDC2/p34 phosphorylation, downregulates Bcl-2, andinteracts with c-myc. By interacting with transferrin receptors, it mediates apoptosisof cancer cells. It inhibits NF-κB pathway. In vivo and in vitro experiments determinedits potential to inhibit angiogenesis and VGEF-2 receptor, and thus it inhibitshuman endothelial cell growth, invasion, and migration, microvessel growth, andtube formation (Zhang et al. 2004; Pandey et al. 2007; Aggarwal et al. 2008).
GA, extract from Garcinia hanburyi, the most important active constituent of gamboge,inhibits the heat shock protein (Hsp90) (Zhang 2010). Hsp90 is the majorprotein in tumour regeneration as well as cell signalling, and its inhibition results ininduction of ER stress, thereby activating UPR target genes and ER stress sensorswhich further cause cell death (Lamoureux et al. 2014). Severe or sustained ERstress increases CHOP expression and stimulates IRE1α apoptotic signalling, ATF6and PERK. CHOP being the major regulator of Bcl2, Bim and DR5 leads to cellularapoptosis preventing tumour progression (Krajarng et al. 2015).

References

[1] DAYONG ZHAI. Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.[J]. Molecular Cancer Therapeutics, 2008, 7 6: 1639-1646. DOI:10.1158/1535-7163.mct-07-2373
[2] KAI ZHAO. Gambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition.[J]. Oncotarget, 2017, 8 16: 27120-27136. DOI:10.18632/oncotarget.15449
[3] JIANCHANG WEI. Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis.[J]. Experimental and therapeutic medicine, 2017, 13 2: 662-668. DOI:10.3892/etm.2017.4021
[4] TINGTING WANG. Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells[J]. Cancer letters, 2008, 262 2: Pages 214-222. DOI:10.1016/j.canlet.2007.12.004

Gambogic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Gambogic acid Suppliers

Global Suppliers ( 299)

Supplier	Tel	Email	Country	ProdList	Advantage
InvivoChem	13549236410	sales@invivochem.cn	China	6745	58
Chengdu Peter-like Biotechnology Co., Ltd.	18108052721	2850505130@qq.com	China	5037	58
Huzhou ZhanShu Biotechnology Co.,Ltd	0572-8889530 18167260939	zsubio@163.com	China	412	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
China Langchem Inc.	0086-21-58956006		China	7798	57
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58

Supplier	Advantage
InvivoChem	58
Chengdu Peter-like Biotechnology Co., Ltd.	58
Huzhou ZhanShu Biotechnology Co.,Ltd	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Beijing HwrkChemical Technology Co., Ltd	55
Shandong Xiya Chemical Co., Ltd	57
Sichuan Kulinan Technology Co., Ltd	57
China Langchem Inc.	57
Dalian Meilun Biotech Co., Ltd.	58

View Latest Price from Gambogic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Gambogic Acid 2752-65-0	$30.00-68.00		98.26%	10g	TargetMol Chemicals Inc.
2026-06-30	GAMBOGIC ACID 2752-65-0		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2023-02-24	Gambogic acid 2752-65-0		5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

Gambogic Acid
2752-65-0
$30.00-68.00
98.26%
TargetMol Chemicals Inc.

GAMBOGIC ACID
2752-65-0
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Gambogic acid
2752-65-0
$0.00
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Gambogic acid Spectrum

GAMBOGIC ACID(2752-65-0)¹HNMR

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GaMbogic aci BETA-GUTTIFERIN BETA-GUTTILACTONE GUTTATIC ACID β-Guttilactone Gambogic acid, 95%, a caspases activator 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)- 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid Gambogic acid, >=98% GUTTIC ACID (z)-methyl-3-pentenyl)- 1,5-methano-1h,3h,11h-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonicacid,3a,4,5, 3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-7-tetrahydro-8-hydroxy-alph b’’-guttiferin cambogicacid 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid B"-Guttiferrin Beta-Guttiferrin Guttatic acid Guttic acid (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid alpha-GaMbogic acid β-Guttiferin Gambogic acid, 97%(HPLC) R,S-Gambogic acid Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem Gambogic Acid (Guttatic Acid, Guttic Acid) gamogic acid (Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid 2-Butenoic acid,2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyran Gambogic acid (7CI) (Z)-4-((1S,3aR,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid Gambogic Acid, 10 mM in DMSO Gambogic Acid, Garcinia hanburyi Abmole M4775-20mg Gambogic-acid 2752-65-0 Gambogic Acid (Standard) Gambogic acid 2752-65-0 C38H44O8 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract