GAMBOGIC ACID
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- $37 - $4151
- Product name: GAMBOGIC ACID
- CAS: 2752-65-0
- MF: C38H44O8
- MW: 628.75
- EINECS:
- MDL Number:MFCD16878985
- Synonyms:GaMbogic aci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGIC ACID;GUTTATIC ACID;β-Guttilactone;Gambogic acid, 95%, a caspases activator;2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
83 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- BroadPharm
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 500mg
- 1g
- 1mlx10mM(inDMSO)
- 10
- 50.00g
- 100.00g
- 50
- 250.00g
- 10 mg
- 10mM(1mLinDMSO)
- 10mM(in1mLDMSO)
- 5mg
- 10mM(in 1mL DMSO)
- 10MG
- 50mg
- 100MG
- 250MG
- 20mg
- 25mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- ManufacturerACHEMBLOCK
- Product numberU106637
- Product descriptionGambogic acid 98.00%
- Packaging100MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU106637
- Product descriptionGambogic acid 98.00%
- Packaging250MG
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX1145
- Product descriptionGambogic acid
- Packaging50mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX1145
- Product descriptionGambogic acid
- Packaging100mg
- Price$742
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA200522
- Product descriptionGambogic acid ≥97%(HPLC)
- Packaging250mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA200522
- Product descriptionGambogic acid ≥97%(HPLC)
- Packaging100mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA200522
- Product descriptionGambogic acid ≥97%(HPLC)
- Packaging50mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPXT0004738
- Product descriptionGAMBOGIC ACID 95.00%
- Packaging10MG
- Price$648.83
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3424
- Product descriptionGambogic acid
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3424
- Product descriptionGambogic Acid
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3424
- Product descriptionGambogic Acid
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3424
- Product descriptionGambogic Acid
- Packaging10mg
- Price$105
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3424
- Product descriptionGambogic Acid
- Packaging25mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S2448
- Product descriptionGambogic Acid 99.42%
- Packaging5mg
- Price$162
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberCFN90172
- Product descriptionGambogic acid ≥98%
- Packaging20mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-N0087
- Product descriptionGambogic Acid 98.34%
- Packaging25mg
- Price$130
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | U106637 | Gambogic acid 98.00% | 100MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | U106637 | Gambogic acid 98.00% | 250MG | $210 | 2026-05-27 | Buy |
| AK Scientific | X1145 | Gambogic acid | 50mg | $375 | 2021-12-16 | Buy |
| AK Scientific | X1145 | Gambogic acid | 100mg | $742 | 2021-12-16 | Buy |
| Ambeed | A200522 | Gambogic acid ≥97%(HPLC) | 250mg | $189 | 2021-12-16 | Buy |
| Ambeed | A200522 | Gambogic acid ≥97%(HPLC) | 100mg | $125 | 2021-12-16 | Buy |
| Ambeed | A200522 | Gambogic acid ≥97%(HPLC) | 50mg | $82 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0004738 | GAMBOGIC ACID 95.00% | 10MG | $648.83 | 2021-12-16 | Buy |
| ApexBio Technology | A3424 | Gambogic acid | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A3424 | Gambogic Acid | 5mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | A3424 | Gambogic Acid | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
| ApexBio Technology | A3424 | Gambogic Acid | 10mg | $105 | 2026-05-06 | Buy |
| ApexBio Technology | A3424 | Gambogic Acid | 25mg | $160 | 2026-05-06 | Buy |
| Arctom | SLK-S2448 | Gambogic Acid 99.42% | 5mg | $162 | 2026-05-26 | Buy |
| Arctom | CFN90172 | Gambogic acid ≥98% | 20mg | $118 | 2021-12-16 | Buy |
| Arctom | HY-N0087 | Gambogic Acid 98.34% | 25mg | $130 | 2026-05-26 | Buy |
Properties
Melting point :88.5°C
Boiling point :586.06°C (rough estimate)
alpha :D20 -685° (methanol)
Density :1.1057 (rough estimate)
refractive index :1.5290 (estimate)
storage temp. :-20°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :4.58±0.36(Predicted)
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :GEZHEQNLKAOMCA-XKZIYDEJSA-N
SMILES :C(O)(=O)/C(/C)=C\C[C@]12C(=O)[C@]3([H])C=C4C(=O)C5=C(O[C@@]41[C@]([H])(C(C)(C)O2)C3)C(C/C=C(\C)/C)=C1O[C@](C)(CC/C=C(\C)/C)C=CC1=C5O |&1:7,10,19,20,35,r|
LogP :6.490 (est)
Boiling point :586.06°C (rough estimate)
alpha :D20 -685° (methanol)
Density :1.1057 (rough estimate)
refractive index :1.5290 (estimate)
storage temp. :-20°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :4.58±0.36(Predicted)
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :GEZHEQNLKAOMCA-XKZIYDEJSA-N
SMILES :C(O)(=O)/C(/C)=C\C[C@]12C(=O)[C@]3([H])C=C4C(=O)C5=C(O[C@@]41[C@]([H])(C(C)(C)O2)C3)C(C/C=C(\C)/C)=C1O[C@](C)(CC/C=C(\C)/C)C=CC1=C5O |&1:7,10,19,20,35,r|
LogP :6.490 (est)
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
Gambogic acid (GA) is a natural product isolated from the G. hanburyi tree that exhibits anti-cancer activity by acting on a variety of cellular pathways. In the apoptotic pathway, GA activates caspases (EC50 = 0.78 μM), inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50 = 1.47, 1.21, 2.02, 0.66, 1.06, 0.79 μM for Bcl-xL, Bcl-2, Bcl-W, Bcl-B, Bfl-1, Mcl-1, respectively), and alters expression of Bcl-2 and Bax. GA binds to the transferrin receptor (IC50 = 4.1 μM), inducing apoptosis in various tumor cell lines. It is a potent, slow inhibitor of Kir2.1 channels (IC50 = <100 nM). GA inhibits the chymotrypsin activity of the 20S proteasome in a dose-dependent manner. A novel mechanism for GA cytotoxic effects in glioma cells may be through AMPK-initiated effects on EGFR and Akt/mTORC1 signaling.More related product prices
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GAMBOGIC ACID
$37-4151
