4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid
- CAS No.
- 6647-98-9
- Chemical Name:
- 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid
- Synonyms
- AKOS B000136;ART-CHEM-BB B000136;4-iodo-1-methylpyrazole-3-carboxylic acid;4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid;4-Iodo--1-methyl-1H-pyrazol-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 4-iodo-1-methyl-
- CBNumber:
- CB1284663
- Molecular Formula:
- C5H5IN2O2
- Molecular Weight:
- 252.01
- MDL Number:
- MFCD00465278
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R432741 | 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR | 6647-98-9 | 1 unit | $32.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | R432741 | 4-IODO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID AldrichCPR | 6647-98-9 | 50MG | $29.8 | 2024-03-01 | Buy |
| Synthonix | K40910 | 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid 95+% | 6647-98-9 | 100mg | $51 | 2026-05-06 | Buy |
| Synthonix | K40910 | 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid 95+% | 6647-98-9 | 250mg | $57 | 2026-05-06 | Buy |
| Synthonix | K40910 | 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid 95+% | 6647-98-9 | 1g | $60 | 2026-05-06 | Buy |
4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
179692-08-1
74-88-4
6647-98-9
General procedure for the synthesis of 4-iodo-1-methyl-1H-pyrazole-3-carboxylic acid from ethyl 4-iodo-1H-pyrazole-3-carboxylate and iodomethane: NaH (60% dispersion in mineral oil, 0.72 g, 18 mmol, 1.2 eq.) was added batchwise to ethyl 4-iodo-1H-pyrazole-3-carboxylate (4.2 g, 15 mmol, 1.0 eq.) in a The mixture was again cooled to 0 °C and iodomethane (1.0 mL, 16.5 mmol, 1.1 eq.) was slowly added. After the reaction mixture solidified, the cold bath was removed and the reaction was continued for 1 h at room temperature. The progress of the reaction was monitored by analytical HPLC to confirm complete consumption of the feedstock and then the reaction was quenched by the slow addition of water (0.5 mL) followed by the slow addition of 2 M NaOH solution (1.0 equiv) under stirring. The reaction mixture was stirred at room temperature until the ester groups were completely hydrolyzed (1-2 hours). The light yellow suspension was filtered and the yellow solid product was collected. The filtrate was concentrated under vacuum and washed with hexane to remove the mineral oil. The aqueous layer and the solid product were combined and the pH was adjusted to 12 with 6N HCl. The aqueous layer was extracted with EtOAc (3 times), the organic phases were combined, washed with brine, dried over anhydrous Na2SO4, and concentrated to give 4-iodo-1-methyl-1H-pyrazole-3-carboxylic acid as a light yellow solid, which can be used without further purification.
References
[1] Patent: WO2017/139603, 2017, A1. Location in patent: Page/Page column 94
4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| HuiFeiChem(WuXi) PharmaTech Co.,Ltd | 0510-0510-83593305 | sales@huifeichem.com | China | 102 | 62 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
| Suzhou Chenke Biotech Co., Ltd. | 18662408853 | 2120408911@qq.com | China | 980 | 55 |
| Anhui CONO Fine Chemical Co., Ltd. | 0550-0550-7097550 15051613561 | sales@ahknchem.com | China | 221 | 60 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai Anmike Chemical Co. Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 9988 | 55 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
View Latest Price from 4-Iodo-1-methyl-1H-pyrazole-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-08 | 4-iodo-1-methylpyrazole-3-carboxylic acid
6647-98-9
|
$3.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-iodo-1-methylpyrazole-3-carboxylic acid
6647-98-9
- $3.00
- 99%
- Career Henan Chemical Co
