1-Methyl-1H-pyrazole-3-carboxylic acid
- CAS No.
- 25016-20-0
- Chemical Name:
- 1-Methyl-1H-pyrazole-3-carboxylic acid
- Synonyms
- SKL262;AKOS B000139;AKOS PAO-0549;TIMTEC-BB SBB000008;ART-CHEM-BB B000139;3-Carboxy-1-methyl-1H-pyrazole;1-METHYLPYRAZOLE-3-CARBOXYLIC ACID;1-Methyl-1H-pyrazol-3-carboxylic acid;1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID;1-Methylpyrazole-3-carboxylic Acid >
- CBNumber:
- CB6273183
- Molecular Formula:
- C5H6N2O2
- Molecular Weight:
- 126.11
- MDL Number:
- MFCD00464254
- MOL File:
- 25016-20-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 150-152 ºC |
|---|---|
| Boiling point | 306.9±15.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 4.05±0.10(Predicted) |
| color | White to Orange to Green |
| InChI | InChI=1S/C5H6N2O2/c1-7-3-2-4(6-7)5(8)9/h2-3H,1H3,(H,8,9) |
| InChIKey | YBFIKNNFQIBIQZ-UHFFFAOYSA-N |
| SMILES | N1(C)C=CC(C(O)=O)=N1 |
| CAS DataBase Reference | 25016-20-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
1-Methyl-1H-pyrazole-3-carboxylic acid price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2642 | 1-Methylpyrazole-3-carboxylic Acid >97.0%(GC)(T) | 25016-20-0 | 200mg | $22 | 2026-04-30 | Buy |
| TCI Chemical | M2642 | 1-Methylpyrazole-3-carboxylic Acid >97.0%(GC)(T) | 25016-20-0 | 1g | $61 | 2026-04-30 | Buy |
| Usbiological | 284576 | 1-Methyl-1H-pyrazole-3-carboxylic acid Asreported | 25016-20-0 | 500mg | $360 | 2026-06-03 | Buy |
| Usbiological | 284576 | 1-Methyl-1H-pyrazole-3-carboxylic acid Asreported | 25016-20-0 | 1g | $549 | 2026-06-03 | Buy |
| Usbiological | 284576 | 1-Methyl-1H-pyrazole-3-carboxylic acid Asreported | 25016-20-0 | 2g | $758 | 2026-06-03 | Buy |
1-Methyl-1H-pyrazole-3-carboxylic acid Chemical Properties, Uses, Production
Uses
1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: 1-methyl-pyrazole-3-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group at position 3. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.
Synthesis
1621-91-6
77-78-1
16034-46-1
25016-20-0
Over 45 minutes, dimethyl sulfate (236 g, 177 mL, 1.87 mol) was slowly added dropwise to a stirred solution of pyrazole-3-carboxylic acid (200 g, 1.78 mol) dissolved in 20% aqueous sodium hydroxide (850 mL) at 40 °C. The reaction mixture was heated at 80 °C for 2 h and subsequently cooled to room temperature. The reaction mixture was filtered and the filtrate was acidified to pH 1 with concentrated hydrochloric acid, the precipitate was collected by filtration, washed with water and dried under vacuum to afford 1-methyl-1H-pyrazole-5-carboxylic acid (85 g, 38% yield). The remaining filtrate was concentrated to 800 mL in vacuum and extracted with chloroform (15 x 400 mL) several times. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum to remove the solvent. The residue was recrystallized by isopropanol to give 1-methyl-1H-pyrazole-3-carboxylic acid (74 g) as a white crystalline solid.
References
[1] J. Gen. Chem. USSR (Engl. Transl.), 1982, vol. 52, # 11, p. 2291 - 2296
[2] Zhurnal Obshchei Khimii, 1982, vol. 52, # 11, p. 2592 - 2598
[3] Patent: WO2004/58702, 2004, A2. Location in patent: Page 30-31; 24
1-Methyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui CONO Fine Chemical Co., Ltd. | 0550-0550-7097550 15051613561 | sales@ahknchem.com | China | 221 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 1-Methyl-1H-pyrazole-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1-Methyl-1H-pyrazole-3-carboxylic acid
25016-20-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 1-Methyl-1H-pyrazole-3-carboxylic acid
25016-20-0
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- 1-Methyl-1H-pyrazole-3-carboxylic acid
25016-20-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Methyl-1H-pyrazole-3-carboxylic acid
25016-20-0
- $8.00
- 99%
- Career Henan Chemical Co
