P-Toluenesulfonic anhydride
- CAS No.
- 4124-41-8
- Chemical Name:
- P-Toluenesulfonic anhydride
- Synonyms
- 4-Methylbenzenesulfonic anhydride;Tosic anhydride;p-Tolylsulfonyl 4-methylbenzenesulfonate;4-TOLUENESULFONIC ANHYDRIDE;Toluene-p-anhydride;3-Toluenesulfonicanhydride;p-Toluenesulfonyl anhydride;P-TOLUENESULFONIC ANHYDRIDE;TOLUENE-4-SULFONIC ANHYDRIDE;P-TOLUENESULPHONIC ANHYDRIDE
- CBNumber:
- CB1292293
- Molecular Formula:
- C14H14O5S2
- Molecular Weight:
- 326.38
- MDL Number:
- MFCD00008548
- MOL File:
- 4124-41-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-127 °C(lit.) |
|---|---|
| Boiling point | 478.0±48.0 °C(Predicted) |
| Density | 1.361±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| form | Powder, Crystals and/or Chunks |
| color | Off-white to gray |
| Sensitive | Moisture Sensitive |
| BRN | 2223702 |
| InChI | 1S/C14H14O5S2/c1-11-3-7-13(8-4-11)20(15,16)19-21(17,18)14-9-5-12(2)6-10-14/h3-10H,1-2H3 |
| InChIKey | PDVFSPNIEOYOQL-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)S(=O)(=O)OS(=O)(=O)c2ccc(C)cc2 |
| CAS DataBase Reference | 4124-41-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2585 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29041000 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
|||||||||
| NFPA 704 |
|
P-Toluenesulfonic anhydride price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 259764 | p-Toluenesulfonic anhydride 97% | 4124-41-8 | 5g | $60.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 259764 | p-Toluenesulfonic anhydride 97% | 4124-41-8 | 25g | $155 | 2026-04-30 | Buy |
| TCI Chemical | T1485 | p-Toluenesulfonic Anhydride >95.0%(T) | 4124-41-8 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | T1485 | p-Toluenesulfonic Anhydride >95.0%(T) | 4124-41-8 | 25g | $134 | 2026-04-30 | Buy |
| Biosynth | FT28875 | p-Toluenesulfonic anhydride | 4124-41-8 | 0.05kg | $398.75 | 2026-06-04 | Buy |
P-Toluenesulfonic anhydride Chemical Properties, Uses, Production
Chemical Properties
Off-white to cream powder
Uses
p-Toluenesulfonic anhydride has been employed as reagent in palladium-catalyzed allylic alkenylation of allylic alcohols with n-butyl acrylate.
Reactions
Used as Reagent for tosylation.
p-Toluenesulfonic anhydride is a reliable way for the tosylation of many nucleophiles, primarily, for alcohols. The regent is a shelf-stable, well-soluble solid and “softer” electrophile than p-toluenesulfonyl chloride. Lipophilic alcohols can be easily tosylated in a very economical and eco-friendly way simply by using Ts2O in water without any catalyst. The tosylation can be realized in a few minutes under microwave assistance, giving p-toluenesulfonic acid as the only byproduct[1]. Besides, it can be applied as an additive in palladium-catalyzed allylic alkenylation of allylic alcohols.
General Description
p-Toluenesulfonic anhydride acts as electrophilic species and activates 2-deoxy-sugar hemiacetals in situ, which reacts stereoselectively with nucleophilic acceptors to afford β-anomers.
Chemical Reactivity
4-Toluenesulfonic anhydride has a high chemical reactivity towards common nucleophilic reagents. It can undergo sulfonylation reaction with alcohol hydroxyl groups or amine compounds under alkaline conditions.
Synthesis
Add p-toluenesulfonic acid and an m-phosphorous compound used as raw materials into a reaction kettle, dropwise adding thionyl chloride while stirring. Controlling the temperature in the reaction kettle at 68-76 ℃ and heating to perform condensation after dropwise addition; inputting water and hydrochloric acid into the reaction kettle, cooling to 0 ℃. The reaction solution generated in the previous step was drawn into the water, vacuum filtration was performed, and centrifuging was used to obtain a crude product, p-toluenesulfonic anhydride. Furthermore, it was inputting ethyl acetate, performing heating reflux, and freezing to perform crystallization, thus obtaining the qualified finished product.
References
[1] OLIVERIO M, COSTANZO P, PAONESSA R, et al. Catalyst-free tosylation of lipophilic alcohols in water†[J]. RSC Advances, 2012, 8: 2548-2552. DOI:10.1039/C2RA23067D.
P-Toluenesulfonic anhydride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaoxing Fangxiao Chemical Co., LTD | +86-13456999252; 13456999252 | shellyhouse39@126.com | China | 41 | 58 |
| Shanghai yongzeng technology co., LTD | 021-021-021-65281118 15921781258 | sales@yongzchem.com | China | 70 | 58 |
| Shanghai Guoyuan Chemical Co., Ltd. | 0512-55170668; 13913095008 | shgyhg@139.com | China | 486 | 58 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 291 | 58 |
| ZOUPING MINGYUAN IMP.&EXP. TRADE CO.,LTD. | 18364991597 | fox793@163.com | China | 21 | 58 |
| Shaanxi Weiyu New Materials Co., Ltd | 13772052144 13772052144 | 308828748@qq.com | China | 3000 | 58 |
| Taizhou Xinhongchuan New Material Co., Ltd | 18651157028 18651157028 | 2579548755@qq.com | China | 1365 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
Related articles
- Preparation Method and Chemical Properties of 4-Methylbenzenesulfonic Anhydride
- 4-Methylbenzenesulfonic Anhydride can be prepared via the acylation of p-toluenesulfonyl chloride with p-toluenesulfonic acid.
- Apr 14,2026
View Latest Price from P-Toluenesulfonic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-09 | P-Toluenesulfonic anhydride
4124-41-8
|
25kg | 98% | 500 | Shanghai Yongzeng Technology Co.,Ltd | ||
 |
2026-09-02 | 4-Methylbenzenesulfonic Anhydride
4124-41-8
|
$6.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-07 | P-Toluenesulfonic anhydride
4124-41-8
|
$1.00-50.00 | 1KG | 99%+ | 500KG | Shaanxi Dideu Medichem Co. Ltd |
-
- P-Toluenesulfonic anhydride
4124-41-8
- 98%
- Shanghai Yongzeng Technology Co.,Ltd
-
- 4-Methylbenzenesulfonic Anhydride
4124-41-8
- $6.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- P-Toluenesulfonic anhydride
4124-41-8
- $1.00-50.00
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
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