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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole structure

CAS No.: 2232-08-8

Chemical Name:: 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

Synonyms: TosI;Tosylimidazole;1-TOSYLIMIDAZOLE;1-Tosyl-1H-imidazole;1-(p-Toluenesulfonyl;1-(4-Tolylsulfonyl)imidazole;1-(P-TOLUENESULFONYL)IMIDAZOLE;1-(p-toluenesulphonyl)imidazole;1-(TOLUENE-4-SULFONYL)IMIDAZOLE;1-(PARA-TOLUENESULPHONYL)IMIDAZOLE

CBNumber:: CB3414604

Molecular Formula:: C10H10N2O2S

Molecular Weight:: 222.26

MDL Number:: MFCD00005285

MOL File:: 2232-08-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:20

Product description	Number	Pack Size	Price
1-(p-Toluenesulfonyl)imidazole 99%	244244	5G	$21
1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N)	T1985	5g	$37
1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N)	T1985	25g	$131
1-(p-Toluenesulfonyl)imidazole	T733858	50mg	$45
1-(4-Tolylsulfonyl)imidazole,99%(HPLC) 99%(HPLC)	26935	250G	$436.8
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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Properties

Melting point	76-78 °C(lit.)
Boiling point	409.1±38.0 °C(Predicted)
Density	1.3038 (rough estimate)
refractive index	1.5650 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	chloroform: soluble25mg/mL, clear, colorless to faintly yellow
pka	1.22±0.10(Predicted)
form	Crystals or Crystalline Powder
color	White to slightly yellow
Sensitive	Moisture Sensitive
BRN	612451
InChI	InChI=1S/C10H10N2O2S/c1-9-2-4-10(5-3-9)15(13,14)12-7-6-11-8-12/h2-8H,1H3
InChIKey	YJYMYJRAQYREBT-UHFFFAOYSA-N
SMILES	C1N(S(C2=CC=C(C)C=C2)(=O)=O)C=CN=1
CAS DataBase Reference	2232-08-8(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P280a-P304+P340-P405-P501a

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

10-21

HS Code

29332900

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Chronic 3
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	244244	1-(p-Toluenesulfonyl)imidazole 99%	2232-08-8	5G	$21	2023-01-07	Buy
TCI Chemical	T1985	1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N)	2232-08-8	5g	$37	2025-07-31	Buy
TCI Chemical	T1985	1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N)	2232-08-8	25g	$131	2025-07-31	Buy
TRC	T733858	1-(p-Toluenesulfonyl)imidazole	2232-08-8	50mg	$45	2021-12-16	Buy
Chem-Impex	26935	1-(4-Tolylsulfonyl)imidazole,99%(HPLC) 99%(HPLC)	2232-08-8	250G	$436.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
244244	5G	$21	Buy
T1985	5g	$37	Buy
T1985	25g	$131	Buy
T733858	50mg	$45	Buy
26935	250G	$436.8	Buy

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Chemical Properties,Uses,Production

Chemical Properties

white to slightly yellow crystals

Uses

Alcohols to azides in one step.1

Uses

1-(p-Toluenesulfonyl)imidazole was used in the synthesis of cationic water soluble cyclodextrin, mono-6^A-(1-butyl-3-imidazolium)-6^A-deoxy-β-cyclodextrin chloride (BIMCD), useful in chiral separation of amino acids and anionic pharmaceuticals by capillary electrophoresis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 547, 1980 DOI: 10.1021/jo01291a044

General Description

1-(p-Toluenesulfonyl)imidazole converts alcohols to azides in one step.

Synthesis

288-32-4

98-59-9

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

2232-08-8

(a) In a three-necked round-bottomed flask equipped with a charging funnel, oil collector, magnetic stirring bar and protected by argon, imidazole (5.502 g, 0.081 mol) was dissolved in 25 mL of anhydrous dichloromethane. After cooling the solution to 0°C, p-toluenesulfonyl chloride (6.78 g, 0.036 mol) dissolved in 25 mL of anhydrous dichloromethane was added slowly and dropwise. The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was subsequently filtered through silica gel and the residual solid was washed with 50 mL hexane/ethyl acetate (1:1, v/v). The filtrate was concentrated in a rotary evaporator, redissolved in 6 mL of ethyl acetate and precipitation was induced by the addition of 60 mL of hexane. The resulting white solid was filtered and dried to give 7.12 g of 1-tosylimidazole (0.032 mol, 89% yield).

References

[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 7, p. 2209 - 2218
[2] Organic Syntheses, 2000, vol. 77, p. 225 - 225
[3] Tetrahedron, 2016, vol. 72, # 3, p. 379 - 391
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 1855 - 1858
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 9, p. 1867 - 1875

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole synthesis

Synthesis of 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole from Imidazole and Tosyl chloride

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Preparation Products And Raw materials

Raw materials

Chloroform Tosyl chloride Imidazole 1-(3-SULFO-4-PHENOXY)-PHENYL-3-HEPTADECYL-4-ISOPROPYL-PYRAZOLINE-5-ONE 4-Methylbenzenesulfonhydrazide

P-TOLUENESULFINIC ACID P-Toluenesulfonic anhydride Sodium p-toluenesulfinate p-Toluenesulfonic acid 1,1'-Carbonyldiimidazole

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Preparation Products

Benzene, [(2,2,2-trifluoroethoxy)methyl]- 1H-Isoindol-1-one, 3-hydroxy- Chlorotrimethylsilane

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Suppliers

Global( 258)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-30	1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2021-07-13	1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 2232-08-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Spectrum

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole(2232-08-8)¹HNMR

2232-08-8(1-[(4-Methylphenyl)sulfonyl]-1H-imidazole)Related Search:

Xylene Levamisole Imidazole Sulfuryl chloride p-Toluenesulfonic acid

Dimethyl sulfone 4-(Trifluoromethyl)benzene-1-sulfonyl chloride Mebendazole 4-Methylbenzenesulfonhydrazide Boc-L-Histidine(Tosyl)

BOC-HIS(TOS)-MERRIFIELD RESIN 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole N-MESITYLENESULFONYLIMIDAZOLE N-Boc-N'-tosyl-D-histidine FMOC-HIS(TOS)-OH

N-ALPHA-(3-NITRO-2-PYRIDINESULFENYL)-N-IM-TOSYL-L-HISTIDINE BOC-HIS(TOS)-OH DCHA BOC-D-HIS(TOS)-OH DCHA

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1-(P-TOLUENESULFONYL)IMIDAZOLE 1-(P-TOLUENESULFONYL)-1H-IMIDAZOLE 1-TOSYLIMIDAZOLE 1-(TOLUENE-4-SULFONYL)IMIDAZOLE Tosylimidazole 1-(p-toluenesulphonyl)imidazole 1H-IMIDAZOLE, 1-[(4-METHYLPHENYL)SULFONYL]- 1-(Toluene-4-sulfonyl)-1H-imidazole 1-(4-Methylphenyl)sulphonyl-1H-imidazole 1-Tosyl-1H-imidazole 1-(PARA-TOLUENESULPHONYL)IMIDAZOLE 1-(P-toluenesulfonyl)-imidazole, HPLC 99% 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 1-(p-Toluenesulfonyl)imidazole ,99% TosI 1-(p-Toluenesulfonyl)imidazole 99% 1-(4-Tolylsulfonyl)imidazole 1-(p-Toluenesulfonyl)imidazole, 98+% white solid 4-Methylphenyl(1H-imidazole-1-yl) sulfone 1-(p-Toluenesulfonyl 1-(Toluene-4-sulphonyl)-1H-imidazole 1-Tosyl-1H-imidazole, 1-[(4-Methylphenyl)sulphonyl]-1H-imidazole (1E,4E)-1,5-bis(4-methoxyphenyl)-3-penta-1,4-dienone 1-(4-methylphenyl)sulfonylimidazole 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole USP/EP/BP 1-(p-Toluenesulfonyl)imidazole 2232-08-8 232-08-8 2232-08-0 223-28-8 2232-8-8 2232-08-08 2322-08-8 Heterocyclic Building Blocks Imidazoles Building Blocks DNA / RNA Synthesis Condensing Agents (DNA / RNA Synthesis) Condensation & Active Esterification Building Blocks Chemical Synthesis Heterocyclic Building Blocks Imidazoles Biochemistry Condensation & Active Esterification Condensing Agents (DNA / RNA Synthesis) Nucleosides, Nucleotides & Related Reagents Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry Coupling Reagent