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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Structure
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole structure
CAS No.
2232-08-8
Chemical Name:
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
Synonyms
1-(P-TOLUENESULFONYL)IMIDAZOLE;1-Tosyl-1H-imidazole;1-(p-toluenesulphonyl)imidazole;TosI;Tosylimidazole;1-TOSYLIMIDAZOLE;1-(p-Toluenesulfonyl;1-(4-Tolylsulfonyl)imidazole;1-(TOLUENE-4-SULFONYL)IMIDAZOLE;1-(P-TOLUENESULFONYL)-1H-IMIDAZOLE
CBNumber:
CB3414604
Molecular Formula:
C10H10N2O2S
Molecular Weight:
222.26
MDL Number:
MFCD00005285
MOL File:
2232-08-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:29:34
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1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Properties

Melting point 76-78 °C(lit.)
Boiling point 409.1±38.0 °C(Predicted)
Density 1.3038 (rough estimate)
refractive index 1.5650 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility chloroform: soluble25mg/mL, clear, colorless to faintly yellow
form Crystals or Crystalline Powder
pka 1.22±0.10(Predicted)
color White to slightly yellow
Sensitive Moisture Sensitive
BRN 612451
InChI InChI=1S/C10H10N2O2S/c1-9-2-4-10(5-3-9)15(13,14)12-7-6-11-8-12/h2-8H,1H3
InChIKey YJYMYJRAQYREBT-UHFFFAOYSA-N
SMILES C1N(S(C2=CC=C(C)C=C2)(=O)=O)C=CN=1
CAS DataBase Reference 2232-08-8(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P280a-P304+P340-P405-P501a
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
F  10-21
HS Code  29332900
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 3
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 244244 1-(p-Toluenesulfonyl)imidazole 99% 2232-08-8 5G $21 2023-01-07 Buy
TCI Chemical T1985 1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N) 2232-08-8 5g $35 2026-04-30 Buy
TCI Chemical T1985 1-(p-Toluenesulfonyl)imidazole >98.0%(HPLC)(N) 2232-08-8 25g $102 2026-04-30 Buy
Usbiological 289687 1-(p-Toluenesulfonyl)-imidazole Asreported 2232-08-8 50g $333 2026-06-03 Buy
Usbiological 289687 1-(p-Toluenesulfonyl)-imidazole Asreported 2232-08-8 100g $460 2026-06-03 Buy
Product number Packaging Price Buy
244244 5G $21 Buy
T1985 5g $35 Buy
T1985 25g $102 Buy
289687 50g $333 Buy
289687 100g $460 Buy

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Chemical Properties,Uses,Production

Chemical Properties

white to slightly yellow crystals

Uses

Alcohols to azides in one step.1

Uses

1-(p-Toluenesulfonyl)imidazole was used in the synthesis of cationic water soluble cyclodextrin, mono-6A-(1-butyl-3-imidazolium)-6A-deoxy-β-cyclodextrin chloride (BIMCD), useful in chiral separation of amino acids and anionic pharmaceuticals by capillary electrophoresis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 547, 1980 DOI: 10.1021/jo01291a044

General Description

1-(p-Toluenesulfonyl)imidazole converts alcohols to azides in one step.

Synthesis

Imidazole

288-32-4

Tosyl chloride

98-59-9

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

2232-08-8

(a) In a three-necked round-bottomed flask equipped with a charging funnel, oil collector, magnetic stirring bar and protected by argon, imidazole (5.502 g, 0.081 mol) was dissolved in 25 mL of anhydrous dichloromethane. After cooling the solution to 0°C, p-toluenesulfonyl chloride (6.78 g, 0.036 mol) dissolved in 25 mL of anhydrous dichloromethane was added slowly and dropwise. The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was subsequently filtered through silica gel and the residual solid was washed with 50 mL hexane/ethyl acetate (1:1, v/v). The filtrate was concentrated in a rotary evaporator, redissolved in 6 mL of ethyl acetate and precipitation was induced by the addition of 60 mL of hexane. The resulting white solid was filtered and dried to give 7.12 g of 1-tosylimidazole (0.032 mol, 89% yield).

References

[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 7, p. 2209 - 2218
[2] Organic Syntheses, 2000, vol. 77, p. 225 - 225
[3] Tetrahedron, 2016, vol. 72, # 3, p. 379 - 391
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 1855 - 1858
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 9, p. 1867 - 1875

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole synthesis

288-32-4
98-59-9
2232-08-8
Synthesis of 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole from Imidazole and Tosyl chloride

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Preparation Products And Raw materials

Raw materials

Chloroform Tosyl chloride Imidazole 1-(3-Sulfo-4-phenoxy)-phenyl-3-heptadecyl-4-isopropyl-pyrazoline-5-one 4-Methylbenzenesulfonhydrazide
p-Toluenesulfinic acid P-Toluenesulfonic anhydride Sodium p-toluenesulfinate p-Toluenesulfonic acid 1,1'-Carbonyldiimidazole

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Preparation Products

Benzene, [(2,2,2-trifluoroethoxy)methyl]- 1H-Isoindol-1-one, 3-hydroxy- Chlorotrimethylsilane

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Suppliers

Global( 260)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 1846 58
Heze Bona Medical Technology Co., LTD 15865805009 15865805009@139.com China 2995 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 58
Heze Bona Medical Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Lastest Price from 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole pictures 2026-03-20 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole pictures 2021-07-13 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-[(4-Methylphenyl)sulfonyl]-1H-imidazole pictures 2021-07-09 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
2232-08-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Spectrum

1-[(4-Methylphenyl)sulfonyl]-1H-imidazole(2232-08-8)1HNMR

2232-08-8(1-[(4-Methylphenyl)sulfonyl]-1H-imidazole)Related Search:

Xylene Levamisole Imidazole Sulfuryl chloride p-Toluenesulfonic acid
Dimethyl sulfone 4-(Trifluoromethyl)benzene-1-sulfonyl chloride Mebendazole 4-Methylbenzenesulfonhydrazide N-Boc-N'-tosyl-D-histidine
1-(2,4,6-Triisopropylphenylsulfonyl)imidazole Boc-L-Histidine(Tosyl) Boc-His(Tos)-Merrifield resin Fmoc-His(Tos)-OH N-Mesitylenesulfonylimidazole
N-alpha-(3-Nitro-2-pyridinesulfenyl)-N-im-tosyl-L-histidine Boc-His(Tos)-OH dcha Boc-D-His(Tos)-OH dcha

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1-(P-TOLUENESULFONYL)-1H-IMIDAZOLE 1-TOSYLIMIDAZOLE 1-(TOLUENE-4-SULFONYL)IMIDAZOLE Tosylimidazole 1H-IMIDAZOLE, 1-[(4-METHYLPHENYL)SULFONYL]- 1-(Toluene-4-sulfonyl)-1H-imidazole 1-(4-Methylphenyl)sulphonyl-1H-imidazole 1-(PARA-TOLUENESULPHONYL)IMIDAZOLE 1-(P-toluenesulfonyl)-imidazole, HPLC 99% 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 1-(p-Toluenesulfonyl)imidazole ,99% TosI 1-(p-Toluenesulfonyl)imidazole 99% 1-(4-Tolylsulfonyl)imidazole 1-(p-Toluenesulfonyl)imidazole, 98+% white solid 4-Methylphenyl(1H-imidazole-1-yl) sulfone 1-(p-Toluenesulfonyl 1-(Toluene-4-sulphonyl)-1H-imidazole 1-Tosyl-1H-imidazole, 1-[(4-Methylphenyl)sulphonyl]-1H-imidazole (1E,4E)-1,5-bis(4-methoxyphenyl)-3-penta-1,4-dienone 1-(4-methylphenyl)sulfonylimidazole 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole USP/EP/BP 1-(p-Toluenesulfonyl)imidazole 1-(P-TOLUENESULFONYL)IMIDAZOLE 1-(p-toluenesulphonyl)imidazole 1-Tosyl-1H-imidazole 2232-08-8 232-08-8 2232-08-0 223-28-8 2232-8-8 2232-08-08 2322-08-8 Heterocyclic Building Blocks Imidazoles Building Blocks DNA / RNA Synthesis Condensing Agents (DNA / RNA Synthesis) Condensation & Active Esterification Building Blocks Chemical Synthesis Heterocyclic Building Blocks Imidazoles Biochemistry Condensation & Active Esterification Condensing Agents (DNA / RNA Synthesis) Nucleosides, Nucleotides & Related Reagents Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry Coupling Reagent