PHENPROCOUMON
- CAS No.
- 435-97-2
- Chemical Name:
- PHENPROCOUMON
- Synonyms
- MARCUMA;Fencumar;Liquamar;Marcumar;Falithrom;Falithiom;Marcoumar;RO 1-4849;Phenprocumon;PHENPROCOUMON
- CBNumber:
- CB1295890
- Molecular Formula:
- C18H16O3
- Molecular Weight:
- 280.32
- MDL Number:
- MFCD00865273
- MOL File:
- 435-97-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Phenprocoumon ≥97% (HPLC) | SML2365 | 5 mg | $83.7 |
| Phenprocoumon ≥97% (HPLC) | SML2365 | 25 mg | $341 |
| Phenprocoumon ≥98% | 31730 | 5mg | $74 |
| Phenprocoumon ≥98% | 31730 | 10mg | $131 |
| Phenprocoumon ≥98% | 31730 | 25mg | $291 |
| More product size | |||
| Melting point | 179-180° |
|---|---|
| Boiling point | 463.2±45.0 °C(Predicted) |
| Density | 1.261±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.50±1.00(Predicted) |
| color | White to Off-White |
| InChI | 1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,20H,2H2,1H3 |
| InChIKey | QNDUUBVQYBBRBW-UHFFFAOYSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | Q08SIO485D |
| Proposition 65 List | Phenprocoumon |
| NCI Drug Dictionary | Liquamar |
| ATC code | B01AA04 |
| EPA Substance Registry System | Phenprocoumon (435-97-2) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H331-H311-H370 | |||||||||
| Precautionary statements | P260-P264-P270-P307+P311-P321-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Repr. 2 STOT RE 2 |
|||||||||
| Hazardous Substances Data | 435-97-2(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
PHENPROCOUMON price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2365 | Phenprocoumon ≥97% (HPLC) | 435-97-2 | 5 mg | $83.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2365 | Phenprocoumon ≥97% (HPLC) | 435-97-2 | 25 mg | $341 | 2026-04-30 | Buy |
| Cayman Chemical | 31730 | Phenprocoumon ≥98% | 435-97-2 | 5mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 31730 | Phenprocoumon ≥98% | 435-97-2 | 10mg | $131 | 2026-04-30 | Buy |
| Cayman Chemical | 31730 | Phenprocoumon ≥98% | 435-97-2 | 25mg | $291 | 2026-04-30 | Buy |
PHENPROCOUMON Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Liquamar ,Organon ,US,1958
Uses
Phenprocoumon is known for being an oral anti-coagulant.
Definition
ChEBI: A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenylpropyl group.
Manufacturing Process
8.3 parts by weight of powdered sodium in 300 parts by volume of benzene, 100 parts by weight of diethyl (1'-phenylpropyl)-malonate and 72 parts by weight of acetylsalicylic acid chloride are reacted together to form diethyl 1(o-acetoxybenzoy1)-1-(1'-phenylpropyl)malonate, which boils at 195°198°C/0.03 mm Hg.
10.3 parts of weight of diethyl 1-(o-acetoxybenzoyl)-1-(1'-phenylpropyl)malonate are dissolved in 60 parts by volume of absolute ether and to this solution are added portion. wise at 10°C, while stirring, 2.6 parts by weight of sodium methylate. The reaction mixture is stirred for 4 hours, whereupon it is poured into ice water. The ether solution is washed neutral with ice water. After having distilled off the ether, a thick oil consisting of 3-carbethoxy-3-(1'phenylpropyl)-4-oxo-dihydrocoumarinis obtained. This compound crystallized in butyl oxide and has a MP of 108°-109°C.
The 3-carbethoxy-3-(1'-phenylpropyl)-4-oxo-dihydrocoumarinmay be hydrolyzed and decarboxylated as follows. The crude product is heated to 85°C for 1/2 hour with 100 parts by volume of 5% aqueous sodium hydroxide, while agitating or stirring. To remove traces of undissolved oil, the cooled solution is treated with 1 part by weight of charcoal, whereupon it is filtrated and acidified to Congo reaction with dilute sulfuric acid. The 3-(1'phenylpropyl)-4-hydroxycoumarin formed is separated off and recrystallized in 80% ethanol, whereupon it melts at 178°-179°C according to US Patent 2,701,804.
brand name
Liquamar (Organon).
Therapeutic Function
Anticoagulant
Biological Activity
Phenprocoumon is a coumarin derivative th at inhibits vitamin K and acts as a long acting oral anticoagulant. It was recently found to act synergistically with flutamide to modulate the stability of the androgen receptor (AR) and resensitize AR-mutant prostate cancer cells to flutamide.
Synthesis
Phenprocoumon, 3-(|á-ethylbenzyl)-4-hydroxycoumarin (24.1.14), is synthesized by acylating sodium salts of diethyl ester (1-phenylpropyl)butyric acid with acetylsalicylic acid chloride, which forms the compound 24.1.12, which upon reaction with sodium ethoxide cyclizes to 3-(|á-ethylbenzyl)-2-carboethoxy-4-hydroxycoumarin (24.1.13). Alkaline hydrolysis of this product and further decarboxylation gives phenprocoumon(24.1.14).
PHENPROCOUMON Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15083 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712697 +8617792793228 | 1069@dideu.com | China | 8609 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
View Lastest Price from PHENPROCOUMON manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Phenprocoumon
435-97-2
|
$30.00-77.00 | 95.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-22 | 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-on
435-97-2
|
1KG | 97.4% | 100 tons | Honest Joy Holdings Limited |
-
- Phenprocoumon
435-97-2
- $30.00-77.00
- 95.79%
- TargetMol Chemicals Inc.
-
- 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-on
435-97-2
- $0.00
- 97.4%
- Honest Joy Holdings Limited
