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4-Bromoisatin

4-Bromoisatin Structure
4-Bromoisatin structure
CAS No.
20780-72-7
Chemical Name:
4-Bromoisatin
Synonyms
4-BROMOINDOLINE-2,3-DIONE;4-BROM;4-Broisatin;4-Bromoisatin;4-Bromoisatin 98%;BUTTPARK 50\07-93;4-Bromoisatin >4- broMoindigo carMine;Fampridine Impurity 25;4-BROMOINDOLE-2,3-DIONE
CBNumber:
CB1301591
Molecular Formula:
C8H4BrNO2
Molecular Weight:
226.03
MDL Number:
MFCD03618555
MOL File:
20780-72-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:49:10
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4-Bromoisatin Properties

Melting point 253-256
Density 1.826±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Dimethylformamide
form powder to crystal
pka 8.73±0.20(Predicted)
color Light yellow to Brown
InChI InChI=1S/C8H4BrNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12)
InChIKey ITRAKBJPMLKWIW-UHFFFAOYSA-N
SMILES N1C2=C(C(Br)=CC=C2)C(=O)C1=O
CAS DataBase Reference 20780-72-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933998090
NFPA 704
0
2 0

4-Bromoisatin price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B2423 4-Bromoisatin >98.0%(GC)(T) 20780-72-7 5g $44 2026-04-30 Buy
TCI Chemical B2423 4-Bromoisatin >98.0%(GC)(T) 20780-72-7 25g $125 2026-04-30 Buy
Usbiological 267117 4-Bromoisatin Asreported 20780-72-7 5g $303 2026-06-03 Buy
Usbiological 267117 4-Bromoisatin Asreported 20780-72-7 10g $415 2026-06-03 Buy
Usbiological 267117 4-Bromoisatin Asreported 20780-72-7 25g $582 2026-06-03 Buy
Product number Packaging Price Buy
B2423 5g $44 Buy
B2423 25g $125 Buy
267117 5g $303 Buy
267117 10g $415 Buy
267117 25g $582 Buy

4-Bromoisatin Chemical Properties,Uses,Production

Application

4-Bromoindigo is an organic bromide that can be used as an intermediate in pharmaceutical synthesis.

Definition

ChEBI: 4-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.

Synthesis

Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)-

65971-74-6

6-Bromoisatin

6326-79-0

4-BROMOISATIN

20780-72-7

The general procedure for the synthesis of 6-bromodihydroindole-2,3-diones and 4-bromoindoline-2,3-diones using 2-hydroxyimino-N-(3-bromophenyl)-acetamide as starting material is as follows: 1. to a solution of hydrogen chloride (50.0 g, 0.247 mol) in water (237 mL) was sequentially added a mixture of anhydrous sodium sulfate (69.0 g, 0.486 mol) and 3-bromoaniline (40.0 g, 0.233 mol) in 37% hydrochloric acid (25 mL). 2. Water (632 mL) was added slowly with vigorous stirring. After addition, the reaction mixture was heated to reflux for 10 minutes and then cooled to room temperature. 3. The precipitate formed was collected by filtration, washed with water (3 x 100 mL) and dried under vacuum to give crude isonitrosoacetanilide. 4. The crude product was added in batches to rapidly stirred concentrated sulfuric acid (790 mL), with the rate of addition controlled to maintain the reaction temperature between 50 and 70 °C. The reaction was carried out in a controlled manner. 5. The reaction mixture was heated to 80°C, held for 20 minutes, and then cooled to room temperature. 6. The cooled mixture was poured into crushed ice (about 320 g) and allowed to stand for 1 hour. 7. The orange precipitate was collected by filtration, washed with water and dried to give a mixture of 4-bromoindigo (K-98) and 6-bromoindigo (K-99) (40 g, 83% yield).

References

[1] Patent: WO2006/44415, 2006, A2. Location in patent: Page/Page column 118
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3125 - 3134
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 935 - 946
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4641 - 4649
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 18 - 36

4-Bromoisatin Preparation Products And Raw materials

Raw materials

Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)- 4-Bromoindoline Chloral hydrate 3-Bromoaniline

Preparation Products

6-Bromoisatinic anhydride 2-amino-6-bromobenzonitrile 6-Bromoisatin 5-broMo-3-hydroxyquinolin-2(1h)-one

4-Bromoisatin Suppliers

Global( 247)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Kaisai Chemical Co., Ltd 021-33516722 13701817765 kaisaichem@163.com China 4604 58
Hefei Lbao Physical & Chemical Science Co.,Ltd +1-5184799099 18755112432 18755112432@163.com China 96 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Shanghai Kaisai Chemical Co., Ltd 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Lastest Price from 4-Bromoisatin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-BROMOISATIN pictures 2026-09-02 4-BROMOISATIN
20780-72-7
 $1.50-36.00 1kg 99% Henan Fengda Chemical Co., Ltd
4-Bromoisatin pictures 2026-05-18 4-Bromoisatin
20780-72-7
 1kg 98% Hefei Lbao Physical & Chemical Science Co.,Ltd
4-BROMOISATIN pictures 2021-08-12 4-BROMOISATIN
20780-72-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • 4-BROMOISATIN pictures
  • 4-BROMOISATIN
    20780-72-7
  • $1.50-36.00
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • 4-Bromoisatin pictures
  • 4-Bromoisatin
    20780-72-7
  • $0.00
  • 98%
  • Hefei Lbao Physical & Chemical Science Co.,Ltd
  • 4-BROMOISATIN pictures
  • 4-BROMOISATIN
    20780-72-7
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

4-Bromoisatin Spectrum

4-BROMOISATIN(20780-72-7)1HNMR

20780-72-7(4-Bromoisatin)Related Search:

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1-(3-amino-2-hydroxypropyl)-4-bromo-2,3-dihydro-1H-indole-2,3-dione 2-(4-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N-methylacetamide N-Boc-4-bromoisatin

1of4

4-BROMO-1H-INDOLE-2,3-DIONE 4-BROMOINDOLE-2,3-DIONE BUTTPARK 50\07-93 4-Bromoisatin 98% 4-BROMO-2,3-INDOLINEDIONE 97.0%(MIN)(HPLC) 4-bromo-1H-indole-2,3-dione(SALTDATA: FREE) 4-broMo-2,3-dihydro-1H-indole-2,3-dione 4-Bromo-1H-indole-2,3-dione, 4-Bromoindolin-2,3-dione 4-Broisatin 4-BROM 4-BroMo isatin 4-BroMo indole-2,3-dione 4- broMoindigo carMine 4-Bromo-2,3-Indolinedione 4-Bromo-1H-indol-2,3-dione 4-Bromoisatin > 1H-Indole-2,3-dione, 4-bromo- 3-Isoxazolecarboxaldehyde,10-methyl- Fampridine Impurity 25 4-BROMOINDOLINE-2,3-DIONE 4-Bromoisatin 20780-72-7 Simple Indoles Indoles Halides Indoline & Oxindole Indoles Simple Indoles Fused Ring Systems K00001