6-Bromoisatin
- CAS No.
- 6326-79-0
- Chemical Name:
- 6-Bromoisatin
- Synonyms
- 6-BROMOINDOLINE-2,3-DIONE;6-BROMO-1H-INDOLE-2,3-DIONE;SW-8;SWF-8;AKOS B01843;AKOS B018432;6-BROMOISATIN;BROMOISATIN(6-);6-Bromoisatin 97%;BUTTPARK 50\07-95
- CBNumber:
- CB4300641
- Molecular Formula:
- C8H4BrNO2
- Molecular Weight:
- 226.03
- MDL Number:
- MFCD01631138
- MOL File:
- 6326-79-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 274°C |
|---|---|
| Density | 1.826±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.83±0.20(Predicted) |
| color | Dark Yellow |
| InChI | InChI=1S/C8H4BrNO2/c9-4-1-2-5-6(3-4)10-8(12)7(5)11/h1-3H,(H,10,11,12) |
| InChIKey | HVPQMLZLINVIHW-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC(Br)=C2)C(=O)C1=O |
| CAS DataBase Reference | 6326-79-0(CAS DataBase Reference) |
| FDA UNII | UVA4QW7PH2 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H317-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P272-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-41-43 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
6-Bromoisatin price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B2424 | 6-Bromoisatin >97.0%(GC)(T) | 6326-79-0 | 5g | $107 | 2026-04-30 | Buy |
| TCI Chemical | B2424 | 6-Bromoisatin >97.0%(GC)(T) | 6326-79-0 | 25g | $333 | 2026-04-30 | Buy |
| Usbiological | B2860-10 | 6-Bromoisatin (6-Bromo-1H-indole-2,3-dione, 6-Bromoindole-2,3-dione, 6-Bromo Isatinic Anhydride, AKOS B018432) | 6326-79-0 | 100mg | $312 | 2026-06-03 | Buy |
| TRC | TRC-B684485-5G | 6-Bromo Isatin | 6326-79-0 | 5g | $84 | 2026-06-03 | Buy |
| AstaTech | 21552 | 6-BROMOISATIN 97% | 6326-79-0 | 1G | $23 | 2026-04-30 | Buy |
6-Bromoisatin Chemical Properties,Uses,Production
Chemical Properties
Orange Powder
Uses
Antimicrobial
Biological Functions
6-Bromoisatin inhibited proliferation of HT29 cells at IC50 223 μM (0.05 mg/mL) and induced apoptosis without increasing caspase 3/7 activity. In vivo 6-bromoisatin (0.05 mg/g) was found to significantly enhance the apoptotic index (p ≤ 0.001) and reduced cell proliferation (p ≤ 0.01) in the distal colon.
Synthesis
65971-74-6
6326-79-0
Step 2: N-(3-bromophenyl)-2-hydroxyiminoacetamide (55 g, 0.2272 mol) was added to concentrated sulfuric acid (275 mL) and the temperature was maintained at 50 °C. The temperature of the reaction system was then raised to 90 °C for 3 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and a yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 6-bromodihydroindole-2,3-dione as a yellow solid (50 g, 98% yield). The resulting product can be used directly in the subsequent reaction without further purification.
Purification Methods
6-Bromoisatin recrystallises from AcOH (yellow needles). It is a plant growth substance. IR in CHCl3 has 1320 and 3440cm-1. [Sadler J Org max Chem 21 169 1956, Beilstein 21 III/IV 5012.]
References
[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 91
[2] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 36-37
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 549 - 554
[4] Medicinal Chemistry, 2014, vol. 10, # 5, p. 484 - 496
[5] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0154-0155
6-Bromoisatin Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YouPeng Chemical Co. Ltd. | 021-69005955 13701776567; | youpengchem@163.com | China | 4153 | 56 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 6-Bromoisatin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-Bromoisatin
6326-79-0
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-18 | 6-Bromoisatin
6326-79-0
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2025-05-23 | 6-Bromoisatin
6326-79-0
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 6-Bromoisatin
6326-79-0
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 6-Bromoisatin
6326-79-0
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 6-Bromoisatin
6326-79-0
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
