GDC-0425
- CAS No.
- 1200129-48-1
- Chemical Name:
- GDC-0425
- Synonyms
- RG7602;RG-7602;GDC-0425;5-(1-ethylpiperidin-4-yloxy)-9H-dipyrido[2,3-b-4',3'-d]pyrrole-6-carbonitrile;5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile;9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-[(1-ethyl-4-piperidinyl)oxy]-
- CBNumber:
- CB13039286
- Molecular Formula:
- C18H19N5O
- Molecular Weight:
- 321.38
- MDL Number:
- MFCD31536987
- MOL File:
- 1200129-48-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 589.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 10.73±0.50(Predicted) |
| form | Solid |
| color | Off-white to brown |
| Water Solubility | Water : 25 mg/mL (77.79 mM; ultrasonic and adjust pH to 3 with HCl) |
| FDA UNII | 4N173XZ7SX |
GDC-0425 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016930 | GDC-0425 99.60% | 1200129-48-1 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-0016930 | GDC-0425 99.60% | 1200129-48-1 | 10mg | $119 | 2026-06-04 | Buy |
| ChemScene | CS-0016930 | GDC-0425 99.60% | 1200129-48-1 | 25mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0016930 | GDC-0425 99.60% | 1200129-48-1 | 50mg | $412 | 2026-06-04 | Buy |
| ChemScene | CS-0016930 | GDC-0425 99.60% | 1200129-48-1 | 100mg | $650 | 2026-06-04 | Buy |
GDC-0425 Chemical Properties, Uses, Production
Uses
GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies[1][2].
in vivo
GDC-0425 exhibits partial suppression of tumor growth. The Gemcitabine/GDC-0425 combination results in significant tumor regression in all tested models[3].
| Animal Model: | NCr nude mice bearing xenografts of both osteosarcoma and triple-negative breast cancer models (143B PML BK TK, HCC1806, and HCC70 cell lines)[3] |
| Dosage: | For the 4-arm study, mice were treated with vehicle, Gemcitabine 120 mg/kg, GDC-0425 75 mg/kg alone, or Gemcitabine and GDC-0425 combination for 15 days. For 6-arm studies of HCC1806 and HCC70 models, mice were treated with vehicle, Gemcitabine 120 mg/kg, GDC-0425 50 mg/kg, GDC-0425 75 mg/kg alone, or Gemcitabine and GDC-0425 combination. |
| Administration: | Orally administrated at 24, 48, and 72 hours after gemcitabine administration by intraperitoneal injection. |
| Result: | Exhibited partial suppression of tumor growth upon treatment with either Gemcitabine or GDC-0425 alone. Notably, the Gemcitabine/GDC-0425 combination resulted in significant tumor regression in all tested models. |
IC 50
Chk1
References
[1] Xiao Ding, et al. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma. Biomed Chromatogr. 2016 Dec;30(12):1984-1991. DOI:10.1002/bmc.3775
[2] Jeffrey R Infante, et al. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clin Cancer Res. 2017 May 15;23(10):2423-2432. DOI:10.1158/1078-0432.CCR-16-1782
[3] Ho-June Lee, et al. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells. Mol Cancer Ther. 2017 Apr;16(4):694-704. DOI:10.1158/1535-7163.MCT-16-0504
GDC-0425 Preparation Products And Raw materials
Raw materials
Preparation Products
GDC-0425 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
| Advanced chemblocks inc | 650-6922368 650-6922368;650-6922368 | sales@achemblock.com | China | 2988 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1881 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sales@pharmablock.com | China | 7266 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
