Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate
- CAS No.
- 676621-95-7
- Chemical Name:
- Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate
- Synonyms
- Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate;Benzenepropanoic acid, 4-fluoro-α,α-dimethyl-, ethyl ester
- CBNumber:
- CB13066077
- Molecular Formula:
- C13H17FO2
- Molecular Weight:
- 224.27
- MDL Number:
- MFCD22987357
- MOL File:
- 676621-95-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA01DLXZ | Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate 97% | 676621-95-7 | 250mg | $68 | 2026-05-29 | Buy |
| aablocks | AA01DLXZ | Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate 97% | 676621-95-7 | 1g | $96 | 2026-05-29 | Buy |
| aablocks | AA01DLXZ | Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate 97% | 676621-95-7 | 5g | $340 | 2026-05-29 | Buy |
| aablocks | AA01DLXZ | Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate 97% | 676621-95-7 | 10g | $663 | 2026-05-29 | Buy |
| aablocks | AA01DLXZ | Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate 97% | 676621-95-7 | 25g | $1107 | 2026-05-29 | Buy |
Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate Chemical Properties, Uses, Production
Synthesis
459-46-1
97-62-1
676621-95-7
Preparation of ethyl 3-(4-fluorophenyl)-2,2-dimethylpropionate: a solution of ethyl isobutyrate (11.03 g, 95 mmol) in tetrahydrofuran (75 mL) was added dropwise to a mixture of lithium bis(trimethylmethylsilyl)amide in tetrahydrofuran (1.0 M, 100 mL, 100 mmol) and tetrahydrofuran (100 mL) over a period of 15 min at -78 °C. (100 mL). The resulting solution was stirred at -78 °C for 45 min, followed by addition of a solution of 1-bromomethyl-4-fluorobenzene (11.5 mL, 92 mmol) in tetrahydrofuran (25 mL) over 5 min. The cooling bath was removed and the reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction was acidified by adding 1.0 N aqueous hydrochloric acid and partitioned. The aqueous phase was extracted with ethyl acetate, and the combined organic phases were washed with 1.0 N aqueous hydrochloric acid, dried over anhydrous sodium sulfate, and concentrated in vacuum to afford the brown liquid product ethyl 3-(4-fluorophenyl)-2,2-dimethylpropionate (20.7 g, quantitative yield), which could be used in subsequent steps without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ7.07 (m, 2H), 6.94 (t, J=9Hz, 2H), 4.10 (q, J=7Hz, 2H), 2.82 (s, 2H), 1.23 (t, J=7Hz, 3H), 1.16 (s, 6H).
References
[1] Patent: US2004/67935, 2004, A1. Location in patent: Page/Page column 29
[2] Patent: WO2005/48932, 2005, A2. Location in patent: Page/Page column 177-178
Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chenzhu Pharmaceutical Co., Ltd. | 13162380607 | 1696175688@qq.com | China | 834 | 55 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Hubei Co-prosperity Medicine Technonlogy Co., Ltd | 2383948258 19172820304 | 2383948258@qq.com | China | 12983 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39662 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 13795461237 | zhuruyan@jskchem.com | China | 49221 | 58 |
| Wuhan WinYuanBei Trading Company | 86-13349903920 13349903920 | 869523959@qq.com | China | 9596 | 58 |
| Shanghai Hansi Chemical Industry Co., Ltd. | 17717618050 | zllg@gh-reagent.com | China | 10418 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13761987713; 13761987713 | hxzheng@sunwaypharm.cn | China | 9905 | 58 |
