Vibegron
- CAS No.
- 1190389-15-1
- Chemical Name:
- Vibegron
- Synonyms
- Vibegron;RVT-901;KRP-114V;Vibegron (MK-4618);(6S)-4,6,7,8-Tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxopyrrolo[1,2-a]pyrimidine-6-carboxamide;Pyrrolo[1,2-a]pyrimidine-6-carboxamide, 4,6,7,8-tetrahydro-N-[4-[[(2S,5R)-5-[(R)-hydroxyphenylmethyl]-2-pyrrolidinyl]methyl]phenyl]-4-oxo-, (6S)-;13C5]-Vibegron;Vibegron-13C-D4;Vibegron，MK-4618，KRP-114V;Nadolol Impurity 6 Hydrochloride
- CBNumber:
- CB13159928
- Molecular Formula:
- C26H28N4O3
- Molecular Weight:
- 444.53
- MDL Number:
- MFCD28502057
- MOL File:
- 1190389-15-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Vibegron 98.09% | CS-0016926 | 1mg | $249 |
| Vibegron 98.09% | CS-0016926 | 5mg | $639 |
| Vibegron 98.09% | CS-0016926 | 10mg | $1029 |
| Vibegron 98.09% | CS-0016926 | 25mg | $1571 |
| Vibegron 98.09% | CS-0016926 | 50mg | $2199 |
| Density | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, away from moisture and light |
| pka | 13.55±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | DJXRIQMCROIRCZ-XOEOCAAJSA-N |
| SMILES | C12CC[C@@H](C(NC3=CC=C(C[C@@H]4CC[C@H]([C@H](O)C5=CC=CC=C5)N4)C=C3)=O)N1C(=O)C=CN=2 |
| FDA UNII | M5TSE03W5U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Vibegron price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016926 | Vibegron 98.09% | 1190389-15-1 | 1mg | $249 | 2026-06-04 | Buy |
| ChemScene | CS-0016926 | Vibegron 98.09% | 1190389-15-1 | 5mg | $639 | 2026-06-04 | Buy |
| ChemScene | CS-0016926 | Vibegron 98.09% | 1190389-15-1 | 10mg | $1029 | 2026-06-04 | Buy |
| ChemScene | CS-0016926 | Vibegron 98.09% | 1190389-15-1 | 25mg | $1571 | 2026-06-04 | Buy |
| ChemScene | CS-0016926 | Vibegron 98.09% | 1190389-15-1 | 50mg | $2199 | 2026-06-04 | Buy |
Vibegron Chemical Properties,Uses,Production
Uses
Vibegron is a potent and selective β3 Adrenergic receptor agonist for the treatment of overactive bladder.
Definition
ChEBI: Vibegron is a pyrrolopyrimidine obtained by formal condensation of the carboxy group of (6S)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid with the amino group of (R)-[(2R,5S)-5-(4-aminobenzyl)pyrrolidin-2-yl](phenyl)methanol. It is a beta3-adrenergic receptor agonist currently in clinical development for the treatment of patients with overactive bladder. It has a role as a beta-adrenergic agonist. It is a secondary alcohol, a member of pyrrolidines, a member of benzenes, a secondary carboxamide, a pyrrolopyrimidine and a secondary amine.
in vivo
Vibegron (1~12 μΜ; i.v.) exhibits dose dependent decreases in micturition pressure and increases in functional bladder capacity[3].
Vibegron (30 mg/kg; p.o.; 4 weeks) upregulates mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α[4].
Vibegron (1 and 10 mg/kg; i.v.; interval 30 minutes) (10 mg/kg) in oxo-M-treated rats makes bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle)[5].
| Animal Model: | Rat |
| Dosage: | 1~12 μΜ |
| Administration: | I.v. |
| Result: | Exhibited dose dependent decreases in micturition pressure and increases in functional bladder capacity. |
| Animal Model: | Female C57BL/6N mice (9 weeks old) |
| Dosage: | 30 mg/kg |
| Administration: | P.o.; 4 weeks |
| Result: | Upregulated mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α at 4 weeks. |
| Animal Model: | Female F344 rats (120–160 g) |
| Dosage: | 1 and 10 mg/kg |
| Administration: | I.v.; Interval 30 minutes |
| Result: | Vibegron (10 mg/kg) in oxo-M-treated rats made bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle). |
IC 50
β adrenergic receptor; β3 adrenoceptor: 1.1 nM (EC50)
Vibegron Preparation Products And Raw materials
Raw materials
Preparation Products
Vibegron Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Protheragen-ING | +86-15618352007 | info@protheragen-ing.com | United States | 3867 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 556 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14035 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +86-15988602810 | sales@anbuchem.com | China | 5812 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 | sales@anikare.com | China | 9993 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1002 | 58 |
| Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-18032440182 +86-18032440182 | sales01@dingminpharma.com | China | 305 | 58 |
| Shaanxi Dideu New Materials Co. Ltd | 18192503167 | 1036@dideu.com | China | 13278 | 58 |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15950 | 58 |
View Lastest Price from Vibegron manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-28 | Vibegron
1190389-15-1
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-08-08 | Vibegron (MK-4618)
1190389-15-1
|
99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |||
 |
2026-06-30 | MB-07133
1190389-15-1
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- Vibegron
1190389-15-1
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Vibegron (MK-4618)
1190389-15-1
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- MB-07133
1190389-15-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
