N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
- CAS No.
- 53774-63-3
- Chemical Name:
- N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
- Synonyms
- L NIL,LNIL;H-LYS(ACETIMIDOYL)-OH;H-LYS(1-IMINOETHYL)-OH;LYSINE(ACETIMIDOYL)-OH;Ne-Acetimidoyl-L-lysine;N-ε-Acetimidoyl-L-lysine;N-(5-Amino-5-carboxypentyl;L-Lysine, N6-(1-iMinoethyl)-;N-EPSILON-ACETIMIDOYL-L-LYSINE;N-EPSILON-ACETIMIDOYL-L-LYSIN-EPSILON
- CBNumber:
- CB1325601
- Molecular Formula:
- C8H17N3O2
- Molecular Weight:
- 187.24
- MDL Number:
- MFCD00792818
- MOL File:
- 53774-63-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 335.2±52.0 °C(Predicted) |
|---|---|
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | -15°C |
| solubility | Water: 50 mg/mL (267.04 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| pka | 2.52±0.24(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | G5QA32XVN5 |
N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FL107911 | H-Lys(acetimidoyl)-OH | 53774-63-3 | 250mg | $900 | 2026-06-04 | Buy |
| Biosynth | FL107911 | H-Lys(acetimidoyl)-OH | 53774-63-3 | 500mg | $900 | 2026-06-04 | Buy |
| Biosynth | FL107911 | H-Lys(acetimidoyl)-OH | 53774-63-3 | 1000mg | $900 | 2026-06-04 | Buy |
| Biosynth | FL107911 | H-Lys(acetimidoyl)-OH | 53774-63-3 | 2000mg | $1260 | 2026-06-04 | Buy |
| Biosynth | FL107911 | H-Lys(acetimidoyl)-OH | 53774-63-3 | 5000mg | $2200 | 2026-06-04 | Buy |
N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Chemical Properties,Uses,Production
Uses
L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].
Biological Activity
L-NIL is an inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 value of 3.3 μM for miNOS.
in vitro
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that it is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L -NMA or L-NNA.
in vivo
L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].
| Animal Model: | Adult male Balb/c (20-25 g)[1]. |
| Dosage: | 10 and 30mg/kg. |
| Administration: | Intraperitoneally at the end of CLP and at 6h after sepsis induction. |
| Result: | Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1β protein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle. |
target
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)
IC 50
iNOS
References
[1] Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. DOI:10.1152/ajprenal.00398.2018
[2] Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. DOI:10.1155/2020/3201635
[3] Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. DOI:10.1021/jm00049a007
N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
