2-Ethynylthiophene
- CAS No.
- 4298-52-6
- Chemical Name:
- 2-Ethynylthiophene
- Synonyms
- 2-ETHYNYLTHIOPHENE;TIMTEC-BB SBB008821;2-ethylynethiophene;(2-Thienyl)acetylene;2-Ethynylthiophene>Thiophene, 2-ethynyl-;2-Acetylenylthiophene;(Thien-2-yl)acetylene;2-Ethynylthiophene 90%;2-Ethynylthiophene 95+%
- CBNumber:
- CB1329098
- Molecular Formula:
- C6H4S
- Molecular Weight:
- 108.16
- MDL Number:
- MFCD03425129
- MOL File:
- 4298-52-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 70℃/20Torr |
|---|---|
| Density | 1.080 |
| refractive index | n20/D1.580 |
| Flash point | 42℃ |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| form | clear liquid |
| color | Light yellow to Brown |
| InChI | InChI=1S/C6H4S/c1-2-6-4-3-5-7-6/h1,3-5H |
| InChIKey | LWISLHRIEATKTM-UHFFFAOYSA-N |
| SMILES | C1(C#C)SC=CC=1 |
| CAS DataBase Reference | 4298-52-6 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38-36 | |||||||||
| Safety Statements | 16-23-26-36/37/39 | |||||||||
| RIDADR | UN 1993C 3 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Ethynylthiophene price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS010938 | 2-ethynylthiophene Aldrich | 4298-52-6 | 100mg | $136 | 2026-04-30 | Buy |
| TCI Chemical | E0915 | 2-Ethynylthiophene >96.0%(GC) | 4298-52-6 | 1g | $69 | 2026-04-30 | Buy |
| TCI Chemical | E0915 | 2-Ethynylthiophene >96.0%(GC) | 4298-52-6 | 5g | $237 | 2026-04-30 | Buy |
| Apolloscientific | OR9291 | 2-Ethynylthiophene 95% | 4298-52-6 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR9291 | 2-Ethynylthiophene 95% | 4298-52-6 | 5g | $63 | 2026-06-04 | Buy |
2-Ethynylthiophene Chemical Properties, Uses, Production
Chemical Properties
Clear yellow liquid
Uses
2-Ethynylthiophene is used in preparation of triazole derivative as Hsp90 inhibitors and anti-cancer metastasis drugs.
Definition
ChEBI: 2-Ethynylthiophene is a heteroarene.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 1487, 1976 DOI: 10.1021/jo00871a001
Synthesis, p. 589, 1996 DOI: 10.1055/s-1996-4265
Synthesis
40231-03-6
4298-52-6
The general procedure for the synthesis of 2-trimethylsilylthienylthiophene from 2-trimethylsilylthienylthiophene was as follows: 2-[(trimethylmethylsilyl)ethynyl]thiophene (1 mmol), an inorganic base (potassium tert-butoxide, sodium tert-butoxide, potassium hydroxide, sodium hydroxide, or potassium trimethylsilyl, sodium trimethylsilyl, 0.05 mmol), and 2 mL of DMA or DMSO solvent were added in turn to a 10-mL in a sealed tube. The reaction mixture was placed in an oil bath at 60 °C and stirred for 6 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, an equal volume of homotrimethylene or n-undecane was added to the crude product. The exact yield of the product was determined by GC and GC-MS. The yields of the products were 59%, 66%, 75%, 77%, 92%, and 85% when DMSO was used as the reaction solvent and potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylmethylsilyl, sodium trimethylmethylsilyl were used as the catalysts, respectively. When DMA was used as the reaction solvent, with the same catalyst, the yields of the products were 51%, 60%, 67%, 70%, 81%, 72%, respectively.
References
[1] Journal of Organic Chemistry, 1996, vol. 61, # 20, p. 6906 - 6921
[2] Patent: CN107459438, 2017, A. Location in patent: Paragraph 0080; 0081
[3] Organic Letters, 2017, vol. 19, # 19, p. 5182 - 5185
[4] Chemistry - A European Journal, 2018, vol. 24, # 15, p. 3725 - 3728
[5] Journal of Chemical Research, 2007, # 12, p. 728 - 732
2-Ethynylthiophene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yao Sen Biotechnology Co., LTD | 18916117619 18916117619 | 2648165562@qq.com | China | 492 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Ethynylthiophene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Ethynylthiophene
4298-52-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-05-18 | 2-Ethynylthiophene
4298-52-6
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2019-07-11 | 2-Ethynylthiophene
4298-52-6
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 2-Ethynylthiophene
4298-52-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Ethynylthiophene
4298-52-6
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 2-Ethynylthiophene
4298-52-6
- $8.80
- 97%-99%
- Career Henan Chemical Co
