Ethyl 2-bromopropionate
- CAS No.
- 535-11-5
- Chemical Name:
- Ethyl 2-bromopropionate
- Synonyms
- ETHYL 2-BROMOPROPANOATE;DL-ETHYL 2-BROMOPROPIONATE;Ethyl 2-broMopropion;Ethyl-bromopropanoate;Ethyl 2-bromopropiote;Ethyl a-bromopropionate;ETHYL 2-BROMOPROPIONATE;Flurbiprofen impurity Ⅱ;Sacubitril Impurity 112;ethyl α-bromo propionoate
- CBNumber:
- CB1329902
- Molecular Formula:
- C5H9BrO2
- Molecular Weight:
- 181.03
- MDL Number:
- MFCD00000144
- MOL File:
- 535-11-5.mol
- MSDS File:
- SDS
| Melting point | <25 °C |
|---|---|
| Boiling point | 156-160 °C (lit.) |
| Density | 1.394 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 125 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless to very slightly yellow |
| Water Solubility | Immiscible |
| Merck | 14,3772 |
| BRN | 773920 |
| Dielectric constant | 9.3000000000000007 |
| Stability | Corrosive |
| InChIKey | ARFLASKVLJTEJD-UHFFFAOYSA-N |
| CAS DataBase Reference | 535-11-5(CAS DataBase Reference) |
| FDA UNII | CDA70611LZ |
| NIST Chemistry Reference | Propanoic acid, 2-bromo-, ethyl ester(535-11-5) |
| EPA Substance Registry System | Propanoic acid, 2-bromo-, ethyl ester (535-11-5) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,Xn | |||||||||
| Risk Statements | 10-34-36/37/38-20/22 | |||||||||
| Safety Statements | 16-26-36/37/39-45-37/39 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA2451730 | |||||||||
| F | 8-19 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159080 | |||||||||
| Toxicity | LD50 orally in Rabbit: 281 mg/kg | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Ethyl 2-bromopropionate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E14551 | Ethyl 2-bromopropionate 99% | 535-11-5 | 25g | $36.7 | 2025-07-31 | Buy |
| Sigma-Aldrich | E14551 | Ethyl 2-bromopropionate 99% | 535-11-5 | 100g | $66.1 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.20219 | Ethyl 2-bromopropionate for synthesis | 535-11-5 | 250ML | $108 | 2022-05-15 | Buy |
| TCI Chemical | B0646 | Ethyl 2-Bromopropionate >98.0%(GC) | 535-11-5 | 25g | $22 | 2025-07-31 | Buy |
| TCI Chemical | B0646 | Ethyl 2-Bromopropionate >98.0%(GC) | 535-11-5 | 100g | $49 | 2025-07-31 | Buy |
Ethyl 2-bromopropionate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to very slightly yellow liquid
Uses
Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.
Uses
It?s an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field.
Synthesis
64-17-5
598-72-1
535-11-5
General procedure for the synthesis of ethyl 2-bromopropionate from ethanol and 2-bromopropionic acid: (a) (ii) A solution of Et2O (5 mL) in 1 M HCl was added to a solution of EtOH (200 mL) in 2-bromopropionic acid (25 g). The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator to give a yellow oily product, ethyl 2-bromopropionate, in a yield of 20.4 g (about 75% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 4.36 (q, J = 7.00 Hz, 1H), 4.24 (qd, J = 7.00 Hz, 2.69 Hz, 2H), 1.83 (d, J = 7.08 Hz, 3H), 1.31 (t, J = 7.20 Hz, 3H).
Purification Methods
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils
References
[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 304 - 309
[2] Patent: WO2010/86613, 2010, A1. Location in patent: Page/Page column 39
[3] Journal of the American Chemical Society, 2014, vol. 136, # 50, p. 17662 - 17668
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13
[5] Monatshefte fuer Chemie, 1881, vol. 2, p. 546
Ethyl 2-bromopropionate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12248 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20185 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Yancheng Longshen Chemical Co.,Ltd. | +86-0515-88706880 +86-18352070299 | sales@longshenchem.com | China | 79 | 55 |
View Lastest Price from Ethyl 2-bromopropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-30 | Ethyl 2-bromopropionate
535-11-5
|
US $0.00-0.00 / kg | 1kg | 99% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-09-25 | Ethyl (2S)-2-bromopropanoate
535-11-5
|
US $122.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-09-10 | Ethyl 2-bromopropionate
535-11-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- Ethyl 2-bromopropionate
535-11-5
- US $0.00-0.00 / kg
- 99%
- Hebei Junhua Import and Export Co., LTD
-
- Ethyl (2S)-2-bromopropanoate
535-11-5
- US $122.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Ethyl 2-bromopropionate
535-11-5
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
