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Ethyl 2-bromopropionate

Ethyl 2-bromopropionate structure

CAS No.: 535-11-5

Chemical Name:: Ethyl 2-bromopropionate

Synonyms: ETHYL 2-BROMOPROPANOATE;DL-ETHYL 2-BROMOPROPIONATE;Ethyl 2-broMopropion;Ethyl-bromopropanoate;Ethyl 2-bromopropiote;Ethyl a-bromopropionate;ETHYL 2-BROMOPROPIONATE;Flurbiprofen impurity Ⅱ;Sacubitril Impurity 112;2-Bromopropionate ethyl

CBNumber:: CB1329902

Molecular Formula:: C5H9BrO2

Molecular Weight:: 181.03

MDL Number:: MFCD00000144

MOL File:: 535-11-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:30:45

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Ethyl 2-bromopropionate Properties

Melting point	<25 °C
Boiling point	156-160 °C (lit.)
Density	1.394 g/mL at 25 °C (lit.)
refractive index	n20/D 1.446(lit.)
Flash point	125 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
color	Clear colorless to very slightly yellow
Water Solubility	Immiscible
Merck	14,3772
BRN	773920
Dielectric constant	9.3000000000000007
Stability	Corrosive
InChI	1S/C5H9BrO2/c1-3-8-5(7)4(2)6/h4H,3H2,1-2H3
InChIKey	ARFLASKVLJTEJD-UHFFFAOYSA-N
SMILES	CCOC(=O)C(C)Br
CAS DataBase Reference	535-11-5(CAS DataBase Reference)
FDA UNII	CDA70611LZ
NIST Chemistry Reference	Propanoic acid, 2-bromo-, ethyl ester(535-11-5)
EPA Substance Registry System	Propanoic acid, 2-bromo-, ethyl ester (535-11-5)
UNSPSC Code	12352108
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05

Signal word

Danger

Hazard statements

H226-H314

Precautionary statements

P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

C,Xn

Risk Statements

10-34-36/37/38-20/22

Safety Statements

16-26-36/37/39-45-37/39

RIDADR

UN 2920 8/PG 2

WGK Germany

RTECS

UA2451730

8-19

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29159080

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3
Skin Corr. 1B

Toxicity

LD50 orally in Rabbit: 281 mg/kg

REACH Registrations

Active

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
3		0

Ethyl 2-bromopropionate price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E14551	Ethyl 2-bromopropionate 99%	535-11-5	25g	$39.1	2026-04-30	Buy
Sigma-Aldrich	E14551	Ethyl 2-bromopropionate 99%	535-11-5	100g	$70.4	2026-04-30	Buy
Sigma-Aldrich	8.20219	Ethyl 2-bromopropionate for synthesis	535-11-5	250ML	$108	2022-05-15	Buy
TCI Chemical	B0646	Ethyl 2-Bromopropionate >98.0%(GC)	535-11-5	25g	$27	2026-04-30	Buy
TCI Chemical	B0646	Ethyl 2-Bromopropionate >98.0%(GC)	535-11-5	100g	$56	2026-04-30	Buy

Product number	Packaging	Price	Buy
E14551	25g	$39.1	Buy
E14551	100g	$70.4	Buy
8.20219	250ML	$108	Buy
B0646	25g	$27	Buy
B0646	100g	$56	Buy

Ethyl 2-bromopropionate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to very slightly yellow liquid

Uses

Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.

Uses

Its an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field.

Synthesis

64-17-5

598-72-1

535-11-5

General procedure for the synthesis of ethyl 2-bromopropionate from ethanol and 2-bromopropionic acid: (a) (ii) A solution of Et2O (5 mL) in 1 M HCl was added to a solution of EtOH (200 mL) in 2-bromopropionic acid (25 g). The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator to give a yellow oily product, ethyl 2-bromopropionate, in a yield of 20.4 g (about 75% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 4.36 (q, J = 7.00 Hz, 1H), 4.24 (qd, J = 7.00 Hz, 2.69 Hz, 2H), 1.83 (d, J = 7.08 Hz, 3H), 1.31 (t, J = 7.20 Hz, 3H).

Purification Methods

Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 304 - 309
[2] Patent: WO2010/86613, 2010, A1. Location in patent: Page/Page column 39
[3] Journal of the American Chemical Society, 2014, vol. 136, # 50, p. 17662 - 17668
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 197, p. 13
[5] Monatshefte fuer Chemie, 1881, vol. 2, p. 546

Ethyl 2-bromopropionate Preparation Products And Raw materials

Raw materials

Ethanol Propionic acid Bromopropionyl bromide 2-Bromopropionyl chloride Thionyl chloride

2-Bromopropionic acid Diethyl ether Hydrochloric acid

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Preparation Products

4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)- Oxiracetam 2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID 2-(2-OXO-2H-CHROMEN-7-YLOXY)-PROPIONIC ACID 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE

5-METHYLPYRIMIDIN-4-OL 4-Hydroxy-5-methyl-2-mercaptopyrimidine

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Ethyl 2-bromopropionate Suppliers

Global( 516)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Hubei yongkuo Technology Co., Ltd	027-59223108 15972152991	1248580099@qq.com	China	9910	58
Shouguang Tongshun Chemical Co., Ltd	13792625218	2103858215@qq.com	China	64	58
Yancheng Longshen Chemical Co.,Ltd.	0515-88718898 18352070236	2355801706@qq.com	China	99	60
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Hubei yongkuo Technology Co., Ltd	58
Shouguang Tongshun Chemical Co., Ltd	58
Yancheng Longshen Chemical Co.,Ltd.	60
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81

View Lastest Price from Ethyl 2-bromopropionate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	Ethyl (2S)-2-bromopropanoate 535-11-5	$1.00-122.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-05-28	Ethyl 2-Bromopropionate 535-11-5	$19.00	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	Ethyl 2-bromopropionate 535-11-5	$1.00	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

Ethyl (2S)-2-bromopropanoate
535-11-5
$1.00-122.00
99%
Henan Fengda Chemical Co., Ltd

Ethyl 2-Bromopropionate
535-11-5
$19.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 2-bromopropionate
535-11-5
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Ethyl 2-bromopropionate Spectrum

Ethyl 2-bromopropionate(535-11-5)MS Ethyl 2-bromopropionate(535-11-5)¹HNMR Ethyl 2-bromopropionate(535-11-5)¹³CNMR Ethyl 2-bromopropionate(535-11-5)IR1 Ethyl 2-bromopropionate(535-11-5)IR2 Ethyl 2-bromopropionate(535-11-5)Raman

535-11-5(Ethyl 2-bromopropionate)Related Search:

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Trinexapac-ethyl Ethyl acetate Ethanol Diethyl 2-bromo-2-methylmalonate Ethyl 2,3-dibromopropionate

DIETHYL DIBROMOMALONATE Ethyl bromodifluoroacetate Ethyl 2-bromoisobutyrate

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2-bromo-propanoicaciethylester Ethyl 2-broMopropion Ethyl 2-broMopropionate 99% Ethyl 2-bromopropiote Ethyl-bromopropanoate Propanoicacid,2-bromo-,ethylester Propionic acid, 2-bromo-, ethyl ester 2-BROMOPROPANOIC ACID ETHYL ESTER 2-BROMOPROPIONIC ACID ETHYL ESTER ALPHA-BROMOPROPIONIC ACID ETHYL ESTER Ethyl (2S)-2-bromopropanoate 2-bromo-propionicaciethylester Ethanol, 2-bromo, propanoate Ethyl alpha-bromopropanoate Ethyl dl-2-bromopropionate ethylalpha-bromopropanoate ethyl α-bromo propionoate Ethyl a-bromopropionate 2-Bromopropanoic acid ethyl 2-Bromopropionic acid ethyl DL-Ethyl 2-bromopropionate,99% DL-Ethyl 2-broMopropionate, 99% 100GR Ethyl 2-bromopropionate ,99% DL-ETHYL 2-BROMOPROPIONATE ETHYL ALPHA-BROMOPROPIONATE ETHYL 2-BROMOPROPIONATE α-Bromopropionic acid, ethyl ester ETHYL A-BROMO PROPIONOATE Flurbiprofen impurity Ⅱ Ethyl 2-Bromopropionate > ETHYL 2-BROMOPROPIONATE FOR SYNTHESIS Alpha - ethyl bromopropionate TIANFU CHEM 535-11-5 Ethyl 2-bromopropionate Ethyl 2-bromopropionate, 98% Sacubitril Impurity 112 2-Bromopropionate ethyl ETHYL 2-BROMOPROPANOATE 535-11-5 CH3CHBrCOOC2H5 CH3CHBrCOC2H5 ESTER Esters Organic Building Blocks Building Blocks Carbonyl Compounds C2 to C5 Esters ACID BASED BROMO COMPOUNDS C2 to C5 Carbonyl Compounds Building Blocks C2 to C5 Carbonyl Compounds Chemical Synthesis Organic Building Blocks ester series