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4-Amino-3-methylphenol

4-Amino-3-methylphenol structure

CAS No.: 2835-99-6

Chemical Name:: 4-Amino-3-methylphenol

Synonyms: 4-AMINO-M-CRESOL;4-AMINO-3-METHYLPHENOL;4-AMINO-3-CRESOL;2-AMINO-5-HYDROXYTOLUENE;Phenol, 4-amino-3-methyl-;p-Hydroxy-o-toluidine;3-Methyl-4-aminophenol;JAROCOL 4A3MP;4-amino-meta-;Amino-M-Cresol

CBNumber:: CB1365623

Molecular Formula:: C7H9NO

Molecular Weight:: 123.15

MDL Number:: MFCD00007871

MOL File:: 2835-99-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:34:14

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4-Amino-3-methylphenol Properties

Melting point	176-179 °C (lit.)
Boiling point	229.26°C (rough estimate)
Density	1.0877 (rough estimate)
refractive index	1.5380 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
pka	10.34±0.18(Predicted)
form	Powder
color	Brown
Water Solubility	insoluble
BRN	2078803
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	4-Amino-3-methylphenol (2835-99-6)
InChI	1S/C7H9NO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,8H2,1H3
InChIKey	QGNGOGOOPUYKMC-UHFFFAOYSA-N
SMILES	Cc1cc(O)ccc1N
LogP	0.51 at 22℃
CAS DataBase Reference	2835-99-6(CAS DataBase Reference)
EWG's Food Scores	3-6
FDA UNII	12R07I1K8C
NIST Chemistry Reference	4-Amino-3-methyl phenol(2835-99-6)
EPA Substance Registry System	Phenol, 4-amino-3-methyl- (2835-99-6)
UNSPSC Code	41116107
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H315-H319-H400

Precautionary statements

P273-P301+P312+P330-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38-20/21/22

Safety Statements

26-37/39-36/37/39-36-24/25

RIDADR

UN3077

WGK Germany

RTECS

GO6826000

8-10-23

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29222900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2

REACH Registrations

Active

NFPA 704

	1
2		0

4-Amino-3-methylphenol price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	144894	4-Amino-3-methylphenol 97%	2835-99-6	5g	$81.2	2026-04-30	Buy
Sigma-Aldrich	144894	4-Amino-3-methylphenol 97%	2835-99-6	25g	$170	2026-04-30	Buy
TCI Chemical	A0288	4-Amino-m-cresol >98.0%(GC)(T)	2835-99-6	25g	$67	2026-04-30	Buy
TCI Chemical	A0288	4-Amino-m-cresol min. 98.0 %	2835-99-6	100G	$139	2026-04-30	Buy
Usbiological	260059	4-Amino-m-cresol Asreported	2835-99-6	25g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
144894	5g	$81.2	Buy
144894	25g	$170	Buy
A0288	25g	$67	Buy
A0288	100G	$139	Buy
260059	25g	$333	Buy

4-Amino-3-methylphenol Chemical Properties,Uses,Production

Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Chemical Properties

Light gray powder

Uses

4-Amino-3-methylphenol is a useful reagent for the synthesis of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.
4-Amino-3-methylphenol was used in synthesis of a new type of tweezer-molecule in which a strongly preferred binding conformation is generated by convergent, intramolecular hydrogen bonding.

Application

4-Amino-m-cresol is used as an oxidative hair dye at a maximum concentration of 1.5% after mixing with peroxide.

Definition

ChEBI: 4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.

General Description

4-Amino-3-methylphenol is a metabolite of 3-methyl-4-nitrophenol. It is a major metabolite of carcinogenic o-toluidine and causes DNA damage in the presence of Cu(II).

Flammability and Explosibility

Not classified

Synthesis

The synthesis of 4-Amino-3-methylphenol is as follows:A mixture of the para-benzoquinone mono-oxime (1.26 mmol),SnCl₂ (0.72 g, 3.80 mmol), 20 mL of CH₂Cl₂, and 0.2 mL of concentrated HCl, was heated to reflux for 16 h. The CH₂Cl₂ was removed under reduced pressure, and the residue was dissolved in ethyl acetate and washed with concentrated aqueous NaHCO₃. The organic layer was dried over anhydrous Na₂SO₄ and the filtrate was concentrated under reduced pressure to afford the solid product.
synthesis of 4-Amino-m-cresol

Purification Methods

Crystallise it from 50% EtOH. [Beilstein 13 H 593, 13 IV 1698.]

4-Amino-3-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indazol-5-ol

4-Amino-3-methylphenol Suppliers

Global( 436)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuxi KaiLi Biotech Co.,Ltd	0510-80721533 13327925606	sales@klbiotech.com	China	134	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Hangzhou Beishengyuan Biotechnology Co., Ltd	15700194842 15700194842	1289372011@qq.com	China	156	58
Hubei Shishun Biotechnology Co. Ltd	027-59223025 15107168801	1718480011@qq.com	China	9402	58
Nanjing Tiangong Industrial Co., Ltd	18083705188; 18083705188	sales@tg-chemical.com	China	129	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Wuxi KaiLi Biotech Co.,Ltd	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Hangzhou Beishengyuan Biotechnology Co., Ltd	58
Hubei Shishun Biotechnology Co. Ltd	58
Nanjing Tiangong Industrial Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

4-Amino-3-methylphenol: Synthesis & Analytical Determination
4-Amino-3-methylphenol is re-evaluated for safety, prepared via green catalytic hydrogenation, and sensitively detected by HPL....
Feb 27,2026

View Lastest Price from 4-Amino-3-methylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	4-Amino-3-Methylphenol 2835-99-6	$19.00	1KG	99.%	50 ton	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	4-Amino-m-cresol 2835-99-6	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-07-29	4-Amino-m-cresol 2835-99-6	$6.00	1kg	99%	2000KG/Month	HebeiShuoshengImportandExportco.,Ltd

4-Amino-3-Methylphenol
2835-99-6
$19.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

4-Amino-m-cresol
2835-99-6
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Amino-m-cresol
2835-99-6
$6.00
99%
HebeiShuoshengImportandExportco.,Ltd

4-Amino-3-methylphenol Spectrum

4-Amino-m-cresol(2835-99-6)¹HNMR 4-Amino-m-cresol(2835-99-6)¹³CNMR 4-Amino-m-cresol(2835-99-6)IR1 4-Amino-m-cresol(2835-99-6)Raman

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