DFMO
- CAS No.
- 66640-93-5
- Chemical Name:
- DFMO
- Synonyms
- EFLORNITINE;L-Eflornithine;DIFLUOROMETHYLORNITHINE;DFMO;L-DFMO;L-RMI71782;H-DL-(F2ME)ORN-OH;L-α-difluoromethylornithine;L Eflornithine,LEflornithine;H-ALPHA-DIFLUORO-ME-DL-ORN-OH
- CBNumber:
- CB1373228
- Molecular Formula:
- C6H12F2N2O2
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00221766
- MOL File:
- 66640-93-5.mol
- MSDS File:
- SDS
| Boiling point | 347.0±42.0 °C(Predicted) |
|---|---|
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 1.22±0.44(Predicted) |
| NCI Dictionary of Cancer Terms | difluoromethylornithine |
| FDA UNII | C780YUS9YI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
DFMO Chemical Properties, Uses, Production
Uses
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].
Biological Activity
L-Eflornithine (L-DFMO) is the enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with KD of 1.3±0.3 μM and Kinact of 0.15±0.03 min-1.
in vivo
The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine. The plasma concentrations of L-Eflornithine are on average 52% of the D -enantiomer concentrations. The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.
target
KD: 1.3±0.3 μM (Ornithine decarboxylase, ODC)
References
[1] Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375(Pt 2):465-70. DOI:10.1042/BJ20030382
[2] Jansson-Lfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307. DOI:10.1128/AAC.04101-14
DFMO Preparation Products And Raw materials
Raw materials
Preparation Products
DFMO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Sanover (Xiamen) Technology Co., Ltd | 请加微信(同手机号)或QQ询价 13876246362 | 422165847@qq.com | China | 500 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sanover (Xiamen) Technology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
View Latest Price from DFMO manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | L-Eflornithine
66640-93-5
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | L-Eflornithine
66640-93-5
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- L-Eflornithine
66640-93-5
- $1520.00-2500.00
- TargetMol Chemicals Inc.
-
- L-Eflornithine
66640-93-5
- $1520.00-2500.00
- TargetMol Chemicals Inc.
