N-(tert-Butoxycarbonyl)-p-toluenesulfonamide
- CAS No.
- 18303-04-3
- Chemical Name:
- N-(tert-Butoxycarbonyl)-p-toluenesulfonamide
- Synonyms
- tert-Butyl tosylcarbamate;TsNBoc;tert-butyl N-(4-methylphenyl)sulfonylcarbamate;N-BOC-P-TOLUENESULFONAMIDE;LABOTEST-BB LT00453242;N-Boc-toluenesulfonamide;tert-Butyl N-tosylcarbamate;tert-Butyl N-(p-tosyl)carbamate;(tert-Butoxycarbonyl)tosylamine;N-Boc-4-methylbenzenesulfonamide
- CBNumber:
- CB1380558
- Molecular Formula:
- C12H17NO4S
- Molecular Weight:
- 271.33
- MDL Number:
- MFCD00134267
- MOL File:
- 18303-04-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-123 °C(lit.) |
|---|---|
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | chloroform: soluble25mg/mL, clear, colorless |
| pka | 4.84±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C12H17NO4S/c1-9-5-7-10(8-6-9)18(15,16)13-11(14)17-12(2,3)4/h5-8H,1-4H3,(H,13,14) |
| InChIKey | DUTLOVSBVBGNDM-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NS(C1=CC=C(C)C=C1)(=O)=O |
| CAS DataBase Reference | 18303-04-3 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29350090 |
| Storage Class | 10 - Combustible liquids |
N-(tert-Butoxycarbonyl)-p-toluenesulfonamide price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 363839 | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide | 18303-04-3 | 25g | $128 | 2026-04-30 | Buy |
| Sigma-Aldrich | 363839 | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide | 18303-04-3 | 5g | $55 | 2023-06-20 | Buy |
| TCI Chemical | B1648 | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide >98.0%(T) | 18303-04-3 | 10g | $92 | 2026-04-30 | Buy |
| TCI Chemical | B1648 | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide >98.0%(T) | 18303-04-3 | 25g | $172 | 2026-04-30 | Buy |
| Chem-Impex | 37119 | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide ≥98%(HPLC) | 18303-04-3 | 1G | $18.5 | 2026-05-19 | Buy |
N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Chemical Properties, Uses, Production
Description
N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE is an useful component in Mitsunobu reactions for the direct preparation of protected amines from alcohols.
Uses
N-(tert-Butoxycarbonyl)-p-toluenesulfonamide may be used in the preparation of enyne amide, precursor for Pauson-Khand reaction.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 379, 1994 DOI: 10.1016/0040-4039(94)85058-5
General Description
N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a N-substituted sulphonamide and its reaction with N-trityl L-serine esters under Mitsunobu reaction conditions is reported. It can be directly coupled with primary, secondary and allylic alcohols under Mitsunobu conditions to afford various sulfonyl-protected amines.
storage
N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE can be stored for extended periods of time in an amber bottle at rt.
N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Aikon International Limited | 17714375163 | hywu@aikonchem.com | China | 9974 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| jiliang chemicals | 21-62165282 | bidingchem@163.com | China | 1395 | 60 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from N-(tert-Butoxycarbonyl)-p-toluenesulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-08-30 | N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
|
$1.00 | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
18303-04-3
- $1.00
- 98%
- Career Henan Chemical Co
