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| | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Basic information |
| | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Chemical Properties |
| Melting point | 121-123 °C(lit.) | | density | 1.201±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | chloroform: soluble25mg/mL, clear, colorless | | pka | 4.84±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C12H17NO4S/c1-9-5-7-10(8-6-9)18(15,16)13-11(14)17-12(2,3)4/h5-8H,1-4H3,(H,13,14) | | InChIKey | DUTLOVSBVBGNDM-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)NS(C1=CC=C(C)C=C1)(=O)=O | | CAS DataBase Reference | 18303-04-3 |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29350090 | | Storage Class | 10 - Combustible liquids |
| | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Usage And Synthesis |
| Description | N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE is an useful component in Mitsunobu reactions for the direct preparation of protected amines from alcohols. | | Uses | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide may be used in the preparation of enyne amide, precursor for Pauson-Khand reaction. | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 379, 1994 DOI: 10.1016/0040-4039(94)85058-5 | | General Description | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a N-substituted sulphonamide and its reaction with N-trityl L-serine esters under Mitsunobu reaction conditions is reported. It can be directly coupled with primary, secondary and allylic alcohols under Mitsunobu conditions to afford various sulfonyl-protected amines. | | storage | N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE can be stored for extended periods of time in an amber bottle at rt. |
| | N-(tert-Butoxycarbonyl)-p-toluenesulfonamide Preparation Products And Raw materials |
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