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ChemicalBook >> CAS DataBase List >>L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Structure
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid structure
CAS No.
42438-90-4
Chemical Name:
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
Synonyms
CYCLOMETHYLTRYPTOPHAN;(S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID;TCR;TNCA;H-TPI-OH;L -CarL;H-THNH(3)-OH;Lycoperodine 1;TNCA >=98% (HPLC);RARECHEM BK PT 0088
CBNumber:
CB1395455
Molecular Formula:
C12H12N2O2
Molecular Weight:
216.24
MDL Number:
MFCD00272641
MOL File:
42438-90-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:49:13
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L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Properties

Melting point 289 °C (dec.)(lit.)
Boiling point 485.0±45.0 °C(Predicted)
Density 1.377±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
form powder
pka 2.28±0.20(Predicted)
color white to beige
optical activity [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
InChI 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
InChIKey FSNCEEGOMTYXKY-JTQLQIEISA-N
SMILES O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
CAS DataBase Reference 42438-90-4(CAS DataBase Reference)
NCI Dictionary of Cancer Terms TCR
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1711 (S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid ≥98% (HPLC) 42438-90-4 10mg $62.7 2026-04-30 Buy
Sigma-Aldrich SML1711 (S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid ≥98% (HPLC) 42438-90-4 50mg $258 2026-04-30 Buy
TCI Chemical T4198 H-Tpi-OH 42438-90-4 200MG $51 2026-04-30 Buy
TCI Chemical T4198 H-Tpi-OH 42438-90-4 1G $177 2026-04-30 Buy
Usbiological 291475 L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Asreported 42438-90-4 2g $333 2026-06-03 Buy
Product number Packaging Price Buy
SML1711 10mg $62.7 Buy
SML1711 50mg $258 Buy
T4198 200MG $51 Buy
T4198 1G $177 Buy
291475 2g $333 Buy

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Chemical Properties, Uses, Production

Chemical Properties

White to off-white powder

Uses

Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR)[1].

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

References

[1] Shoji Yahara, et al. Steroidal Alkaloid Glycosides from Tomato (Lycopersicon esculentum). J Nat Prod. 2004 Mar;67(3):500-2. DOI:10.1021/np030382x

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Suppliers

Global Suppliers ( 126)
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shenzhen Sungening Bio-Tech Co., Ltd +86-0755-89668383 sales@sungening.com China 1319 65
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9848 55
HBCChem, Inc. +1-510-219-6317 sales@hbcchem.com United States 10628 60
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai HC Biotech Co., Ltd 55
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shenzhen Sungening Bio-Tech Co., Ltd 65
Beijing HuaMeiHuLiBiological Chemical 58
9ding chemical ( Shanghai) Limited 56
Amatek Scientific Co. Ltd. 55
HBCChem, Inc. 60

View Latest Price from L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TNCA pictures 2026-05-11 TNCA
42438-90-4
 $31.00-81.00 99.59% 10g TargetMol Chemicals Inc.
  • TNCA pictures
  • TNCA
    42438-90-4
  • $31.00-81.00
  • 99.59%
  • TargetMol Chemicals Inc.

L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Spectrum

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID(42438-90-4)1HNMR

42438-90-4 (L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) Related Search:

Fmoc-D-1,2,3,4-tetrahydronorharman-3-carboxylic acid Boc-D-1,2,3,4-tetrahydronorharman-3-carboxylic acid Boc-L-1,2,3,4-tetrahydronorharman-3-carboxylic acid 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole Fmoc-L-1,2,3,4-tetrahydronorharman-3-carboxylic acid
(1S,3S)-2,3,4,9-Tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-3-carboxylic acid cis-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-, 1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Fmoc-DL-6-methoxy-1,2,3,4-tetrahydronorharman-1-carboxylic acid Boc-tpi(For)-OH
D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid Boc-DL-6-methoxy-1,2,3,4-tetrahydronorharman-1-carboxylic acid (1S,3S)-1-Ethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid H-TPI-OMe 1,3,4,9-Tetrahydro-β-carboline-2-carboxylic acid methyl ester HCl
9-Formyl-1,2,3,4-tetrahydronorharman-L-3-carboxylic acid hydrochloride L-1,2,3,4-Tetrahydronorharmane-3-carboxylic acid ethyl ester hydrochloride N-alpha-Carbobenzoxy-1,2,3,4-tetrahydronorharman-3-carboxylic acid

1of4

L-TRYPTOLINE-3-CARBOXYLIC ACID H-THNH(3)-OH L-2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACID L-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID 1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID RARECHEM BK PT 0088 L-1,2,3,4-tetrahydronorharmane-3-carboxylic acid L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carb 2,3,4,9-Tetrahydro-1H-β-carboline-3-carboxylic acid (3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (3S)-1,2,3,4-Tetrahydro-β-carboline-3α-carboxylic acid (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3α-carboxylic acid (S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid 4-b]indole-3-carboxylic acid 4-Tetrahydro-9H-pyrido[3 4-Tetrahydro-b-carboline-3-carboxylic acid 9-Tetrahydro-1H-beta-carboline-3-carboxylic acid L -CarL Lycoperodine 1 (3S)-2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, L-Tryptoline-3-carboxylic acid, H-Tpi-OH, L-1,2,3,4-Tetrahydro-b-carboline-3-carboxylic acid (3S)-1,3,4,9-tetrahydro-$b-carbolin-2-ium-3-carboxylate (3S)-1,3,4,9-tetrahydropyrido[5,4-b]indol-2-ium-3-carboxylate (3S)-2,3,4,9-tetrahydro-1H-$b-carboline-3-carboxylic acid (3S)-2,3,4,9-tetrahydro-1H-pyrido[5,4-b]indole-3-carboxylic acid (S)-1,2,3,4-Tetrahydronorharmane-3-carboxylic acid 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, (3S)- L-1,2,3,4-Tetrahydro-β-carbolin-3-carboxylic acid TNCA >=98% (HPLC) Tryptophan Impurity M (S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid - [T91715] (3S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID CYCLOMETHYLTRYPTOPHAN H-TPI-OH TCR TNCA L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid 42438-90-4 2438-90-4 C12H12NO2 Phenylalanine analogs and other aromatic alpha amino acids 1