Dimethyl 3-hydroxyglutarate
- CAS No.
- 7250-55-7
- Chemical Name:
- Dimethyl 3-hydroxyglutarate
- Synonyms
- Dimethyl 3-hydroxypentanedioate;Nsc30047;55275_FLUKA;NISTC7250557;166979_ALDRICH;3-hydroxyglutarate;Dimethyl 3-hydroxygl;DIMETHYL 3-HYDROXYGLUTARATE;Dimethyl 3-hydroxyglutarate 98%;1,5-dimethyl 3-hydroxypentanedioate
- CBNumber:
- CB1396199
- Molecular Formula:
- C7H12O5
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00042841
- MOL File:
- 7250-55-7.mol
- MSDS File:
- SDS
| Boiling point | 139-140 °C/8 mmHg (lit.) |
|---|---|
| Density | 1.192 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform |
| form | Oil |
| pka | 12.60±0.20(Predicted) |
| color | Clear colourless to Pale Yellow |
| BRN | 1776666 |
| InChI | InChI=1S/C7H12O5/c1-11-6(9)3-5(8)4-7(10)12-2/h5,8H,3-4H2,1-2H3 |
| InChIKey | CUPGMRSSZADEIW-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)CC(O)CC(OC)=O |
| CAS DataBase Reference | 7250-55-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Glutaric acid, 3-hydroxy-, dimethyl ester(7250-55-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves |
| Safety Statements | 23-24/25 |
| WGK Germany | 3 |
| HS Code | 29181990 |
| Storage Class | 10 - Combustible liquids |
Dimethyl 3-hydroxyglutarate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 166979 | Dimethyl 3-hydroxyglutarate 98% | 7250-55-7 | 5g | $91.2 | 2023-01-07 | Buy |
| Cayman Chemical | 22919 | 3-Hydroxyglutaric Acid dimethyl ester ≥95% | 7250-55-7 | 1g | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 22919 | 3-Hydroxyglutaric Acid dimethyl ester ≥95% | 7250-55-7 | 5g | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 22919 | 3-Hydroxyglutaric Acid dimethyl ester ≥95% | 7250-55-7 | 10g | $141 | 2026-04-30 | Buy |
| Cayman Chemical | 22919 | 3-Hydroxyglutaric Acid dimethyl ester ≥95% | 7250-55-7 | 25g | $281 | 2026-04-30 | Buy |
Dimethyl 3-hydroxyglutarate Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Yellow Oil
Uses
Dimethyl 3-hydroxyglutarate was used in the synthesis of two chiral fragments representing C1-11 and C12-25 of the polyene macrolide pimaricin.
Uses
Glutaric Acid derivative
General Description
Enantioselective hydrolysis and ammonolysis of dimethyl-3-hydroxyglutarate has been studied using immobilized lipase B isolated from Candida antarctica.
Synthesis
1830-54-2
7250-55-7
To a stirred solution of dimethyl 3-oxoglutarate (17.7 mL, 120.6 mmol) in methanol (315 mL) at 0 °C was added sodium borohydride (3.9 g, 102.5 mmol) in batches. After the reaction mixture was brought to room temperature, the reaction was continued with stirring for 24 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 5-6 by adding solid citric acid to quench the reaction. Subsequently, silica gel (about 1 g) was added to the reaction mixture and the solvent was removed by rotary evaporation. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:1) to afford dimethyl 3-hydroxyglutarate (19.98 g, 94% yield) as a colorless oil.
References
[1] Journal of the Brazilian Chemical Society, 2011, vol. 22, # 1, p. 172 - 175
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3650 - 3653
[3] Journal of Organic Chemistry, 1988, vol. 53, # 7, p. 1567 - 1569
[4] RSC Advances, 2016, vol. 6, # 27, p. 22737 - 22748
[5] Journal of the American Chemical Society, 2009, vol. 131, # 49, p. 17980 - 17985
Dimethyl 3-hydroxyglutarate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Endesa Bio-tech Co., Ltd. | 025-58862853 18915922038 | sales@endesachem.com | China | 590 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Lastest Price from Dimethyl 3-hydroxyglutarate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Dimethyl 3-hydroxyglutarate
7250-55-7
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- Dimethyl 3-hydroxyglutarate
7250-55-7
- $1.00
- 95%-99%
- Career Henan Chemical Co
