2-Ketoglutaric acid

2-Ketoglutaric acid Properties

Melting point	113-115 °C
Boiling point	185.67°C (rough estimate)
Density	1.2821 (rough estimate)
bulk density	800kg/m3
vapor pressure	0.01Pa at 25℃
FLAVIS Number	08.037 \| 2-Oxoglutaric acid
refractive index	1.3920 (estimate)
FEMA	3891 \| 2-OXOPENTANEDIOIC ACID
storage temp.	2-8°C
solubility	H2O: soluble0.1g/mL, clear, colorless
form	Crystalline Powder
pka	2.47(at 25℃)
color	White to slightly yellow
Odor	Odorless
PH	3.09(1 mM solution);2.36(10 mM solution);1.77(100 mM solution)
Water Solubility	Soluble in water, methanol and dimethyl sulfoxide.
Merck	14,5303
JECFA Number	634
BRN	1705689
Henry's Law Constant	9.9×10⁶ mol/(m³Pa) at 25℃, Saxena and Hildemann (1996)
Cosmetics Ingredients Functions	DEODORANT
InChI	1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKey	KPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES	OC(=O)CCC(=O)C(O)=O
LogP	-2.08 at 25℃
Substances Added to Food (formerly EAFUS)	2-OXOPENTANEDIOIC ACID
CAS DataBase Reference	328-50-7(CAS DataBase Reference)
FDA UNII	8ID597Z82X
NIST Chemistry Reference	2-Oxopentanedioic acid(328-50-7)
EPA Substance Registry System	Pentanedioic acid, 2-oxo- (328-50-7)
UNSPSC Code	41116107
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338+P310

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T

Risk Statements

37/38-41-36/37/38-23/24/25

Safety Statements

26-39-45-36/37/39

WGK Germany

3

TSCA

TSCA listed

HS Code

29183000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1

REACH Registrations

Active

NFPA 704

	0
2		0

2-Ketoglutaric acid price More Price(103)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	75890	α-Ketoglutaric acid ≥99.0% (T)	328-50-7	25g	$47.4	2026-04-30	Buy
Sigma-Aldrich	75890	α-Ketoglutaric acid ≥99.0% (T)	328-50-7	100g	$113	2026-04-30	Buy
Sigma-Aldrich	61234	α-Ketoglutaric acid analytical standard	328-50-7	10MG	$98.2	2026-04-30	Buy
Sigma-Aldrich	61234	α-Ketoglutaric acid analytical standard	328-50-7	50MG	$240	2026-04-30	Buy
TCI Chemical	K0005	2-Oxoglutaric Acid >99.0%(T)	328-50-7	25g	$53	2026-04-30	Buy

Product number	Packaging	Price	Buy
75890	25g	$47.4	Buy
75890	100g	$113	Buy
61234	10MG	$98.2	Buy
61234	50MG	$240	Buy
K0005	25g	$53	Buy

2-Ketoglutaric acid Chemical Properties,Uses,Production

Description

2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.

Chemical Properties

2-Ketoglutaric acid is a white to yellowish crystalline powder. It is easily soluble in water, alcohol, and extremely insoluble in ether. It becomes light gray-yellow when stored for a long time, and is easy to deliquescence.

Uses

2-Ketoglutaric acid has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries. It is used as an intermediate in the kreb's cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.

Definition

ChEBI: 2-oxoglutaric acid is an oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle. It has a role as a fundamental metabolite. It derives from a glutaric acid. It is a conjugate acid of a 2-oxoglutarate(1-).

Application

2-Ketoglutaric acid is a derivative of glutaric acid. It plays an important role in the metabolism of microbial cells and It acts as precursor for the synthesis of amino acids and nucleotides. α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline. α-ketoglutaric acid can be prepared in 1:1 and 2:1 L-arginine alpha-ketoglutarate for sports nutrition. mainly as an ingredient in sports nutrition drinks.

Preparation

Synthesis of α-ketoglutaric acid: 225 g of triethyl nitrilotricarboxylate and 600 ml of concentrated hydrochloric acid were mixed and left to pass through. It was concentrated by distillation to 140°C, and the residue was crystallized by cooling to obtain 110-112 g of α-ketoglutaric acid with a yield of 92-93%.

General Description

2-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA), one of the important intermediates in the Krebs cycle, after isocitrate and before succinyl CoA. It is an important nitrogen transporter and is transaminate along with glutamine to form glutamate. It can be used to differentiate microorganisms based on metabolic properties. It also possesses metabolic properties, decreasing the level of hydrogen peroxide in cell culture.

Flammability and Explosibility

Not classified

Biotechnological Applications

a-Ketoglutaric acid is an intermediate of the tricarboxylic acid cycle and the main compound of amino acid and protein metabolism. This organic acid could be used as building-block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions, and wound healing compounds (Otto et al. 2013).

Purification Methods

Crystallise the keto-acid repeatedly from Me2CO/*benzene, EtOAc or ethyl propionate. Dry it in vacuo.[Beilstein 3 IV 1813.]

2-Ketoglutaric acid synthesis

Synthesis of 2-Ketoglutaric acid from 5-Hydroxymethylfurfural

2-Ketoglutaric acid Preparation Products And Raw materials

Raw materials

Succinic acid Pentanedioic acid, 2-oxo-, 1-ethyl ester L-Glutamic acid, N-[(2S)-2-amino-2-carboxyethyl]- (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylic acid Glufosinate-P

4-Hydroxyphenylpyruvic acid 3-Phenylpyruvic acid Succinaldehydic acid 2,5-Furandicarboxylic acid pyridoxal

D(-)-Glutamic acid DL-Glutamic acid L-Tyrosine 2-Aminophenol hydrochloride triethyl nitrilotricarboxylate

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Preparation Products

L-Glutamic-2,3,3,4,4-d5 acid α-Ketoglutaric acid sodium salt 4-Carbethoxybutyrolactone,γ-Carboethoxy-γ-butyrolactone 6-Chloro-pyridazine-3-carboxylic acid ethyl ester

2-Ketoglutaric acid Suppliers

Global( 869)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou lipin Chemical Co., Ltd	0512-67509664 19888480046	3516936381@qq.com	China	111	58
Jingjingpharm	15103327112 13831108726	liuxiuli@jjpharm.cn	China	50	58
Guangzhou Hanhe Life Science Co.,Ltd	13265310610 18776703512	admin@harworldbio.com	China	17	58
Wuxi Jingyao Bio-Technology Co., Ltd.	88770633 13961738808	jingyaobiotech@126.com	China	389	55
Hubei XinghengKang Chemical Technology Co., Ltd.	027-88878869 18162384755	xhkhu2014@163.com	China	240	58
Joyman BIOTECH (Lianyungang) Co., Ltd.	0518-85817797 18661269107	info@joy-man.com	China	41	58
Suzhou Yuanrui Bio-Tech Co., Ltd	18106132862	info@yuanruibio.com	China	292	58
Shenzhen Hygieia Biotechnology Co., Ltd	0755-0755-27208059 18898723287	chloe@hygieia.com.cn	China	64	58
Suzhou NMT Biotech Co., Ltd.	0512-62388427 18012730781	longchengnmt@gmail.com	China	42	58
Zhejiang Lvchuang Biotechnology CO., LTD	18855092084	wangbolun@enlogics.com.cn	China	37	58

Supplier	Advantage
Suzhou lipin Chemical Co., Ltd	58
Jingjingpharm	58
Guangzhou Hanhe Life Science Co.,Ltd	58
Wuxi Jingyao Bio-Technology Co., Ltd.	55
Hubei XinghengKang Chemical Technology Co., Ltd.	58
Joyman BIOTECH (Lianyungang) Co., Ltd.	58
Suzhou Yuanrui Bio-Tech Co., Ltd	58
Shenzhen Hygieia Biotechnology Co., Ltd	58
Suzhou NMT Biotech Co., Ltd.	58
Zhejiang Lvchuang Biotechnology CO., LTD	58

View Lastest Price from 2-Ketoglutaric acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-12	2-Ketoglutaric acid 328-50-7	$10.00	1ASSAYS	99%	100kg	RongNa Biotechnology Co.,Ltd
2026-09-12	alpha-ketoglutarate 328-50-7		1KG	0.98	10000 KG	Nanjing pathgene biotech co .,ltd
2026-09-11	2-Ketoglutaric acid 328-50-7		1kg	99%	20ton	Jinan Jianfeng Chemical Co., Ltd

2-Ketoglutaric acid
328-50-7
$10.00
99%
RongNa Biotechnology Co.,Ltd

alpha-ketoglutarate
328-50-7
0.98
Nanjing pathgene biotech co .,ltd

2-Ketoglutaric acid
328-50-7
99%
Jinan Jianfeng Chemical Co., Ltd

2-Ketoglutaric acid Spectrum

2-Ketoglutaric acid(328-50-7)MS 2-Ketoglutaric acid(328-50-7)¹HNMR 2-Ketoglutaric acid(328-50-7)¹³CNMR 2-Ketoglutaric acid(328-50-7)IR1 2-Ketoglutaric acid(328-50-7)IR2 2-Ketoglutaric acid(328-50-7)Raman

328-50-7(2-Ketoglutaric acid)Related Search:

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Ethyl 2-(Chlorosulfonyl)acetate Diethyl glutarate Folic acid α-Ketoglutaric acid disodium salt α-propargylhomoterephthalic acid dimethyl ester

Citric acid α-Lipoic Acid Ascoric Acid 2-oxoglutaric acid, compound with 5-hydroxy-6-methylpyridine-3,4-dimethanol (1:1) Carbonyl iron powder

L-Ornithine 2-oxoglutarate L-Arginine alpha-ketoglutarate Dimethyl 2-oxoglutarate

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2-KETOGLUTARIC ACID Glutaric acid, 2-oxo- Glutaric acid, alpha keto -Ketoglutaricacid PENTANEDIOIC ACID, 2-OXO- 2-Oxo-1,5-dipentanedioic acid 2-Oxo-1,5-pentanedioic acid 2-oxo-pentanedioicaci 2-Oxpentanedioicacid GAMMA-KETOGLUTARIC ACID KETO-GLU A-KetoglutaricAcidPuriss KetoglutaricAcid,FreeAcid A-KETOGLUTARIC ACID FREE ACID CELL*CULTU RE TESTED A-KETOGLUTARIC ACID FREE ACID 2-KETOGLUTARIC ACID BIOSYNTH 2-KETOGLUTARIC ACID 99+% 2-KETOGLUTARIC ACID, DISODIUM SALT, DIHYDRATE BIOTECH GRADE 99.5% 2-OXOPENTANDIOICACID β-ketoadipic acid 2-KETOGLUTARIC ACID 98.5% 2-Ketoglutaric acid,98% 2-Oxoglutaric acid, 2-Oxopentanedioic acid α-Ketog KETOGLUTARIC ACID, ALPHA (SH) α-Ketoglutaric acid ,99% α-Ketoglutaric acid,2-Oxoglutaric acid, 2-Oxopentanedioic acid 2-Oxoglutaric acid, extra pure 2-Ketoglutaric acid, 98% 100GR 2-Ketoglutaric acid, 98% 25GR α-Ketoglutaric acid(AKG) 2-Ketoglutaric acid SynonyMs 2-Oxoglutaric acid alpha-Ketoglutaric acid >=99.0% (T) Oxoglurate Alpha - ketone Α-Oxoglutaric Or Alpha-Ketoglutaric Acid α-Ketoglutaric acid, 99%, reagent grade 2-OxoglutaricAcid> PECTINASN,N-DIMETHYL-P-TOLUIDINEE α-KetogL 2-oxoglutaricaci 2-Ketoglutaric acidr α-Ketoglutaric acid, 99%+ a-Ketoglutaric acid puriss,99% 25GM a-Ketoglutaric Acid (High Purity) extrapure AR, 99.5% α-KETOGLUTARIC ACID Extra Pure 3'-cGAMP AKG (2-Ketoglutaric acid) KETOGLUTARIC ACID, ALPHA Alpha 2 Ketoglutaric Acid á-Ketoglutaric Acid 99% alpha-Ketoglutaric acid, 98% 2-Ketoglutaric acid (alpha-ketoglutarate) 2-Ketoglutaric acid 99% 2-Oxoglutaric acid[1051941000] 75890-25G 2-Oxoglutaric acid[1051940025] alpha-Ketoglutarate AKG