(1S,2S)-(+)-Pseudoephedrine hydrochloride
- CAS No.
- 345-78-8
- Chemical Name:
- (1S,2S)-(+)-Pseudoephedrine hydrochloride
- Synonyms
- PSEUDOEPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL;sudafed;novafed;D-ISOEPHEDRINE HYDROCHLORIDE;H4B;H4C;H4D;H4H;H4J
- CBNumber:
- CB1399716
- Molecular Formula:
- C10H16ClNO
- Molecular Weight:
- 201.69
- MDL Number:
- MFCD00058088
- MOL File:
- 345-78-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 185-188 °C(lit.) |
|---|---|
| alpha | 61 º (c=5, H2O,2dm tube) |
| storage temp. | Refrigerator (+4°C) |
| solubility | Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride. |
| form | buffered aqueous solution |
| pka | 9.22(at 25℃) |
| biological source | rabbit |
| Merck | 13,8007 |
| BRN | 3915112 |
| LogP | -1.74 at 23℃ and pH7 |
| CAS DataBase Reference | 345-78-8(CAS DataBase Reference) |
| FDA 21 CFR | 310.545; 341.20 |
| EWG's Food Scores | 1 |
| FDA UNII | 6V9V2RYJ8N |
| EPA Substance Registry System | Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8) |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H336 |
| Precautionary statements | P261-P264-P270-P271-P301+P312-P304+P340+P312 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/37/38-36/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-24/25-45-36/37-16-7 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | UL5950000 |
| TSCA | TSCA listed |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29394200 |
| Storage Class | 10 - Combustible liquids |
| Toxicity | LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles) |
| REACH Registrations | Active |
(1S,2S)-(+)-Pseudoephedrine hydrochloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB2105153 | Anti-TFF1 antibody produced in rabbit affinity isolated antibody | 345-78-8 | 100μL | $580 | 2026-04-30 | Buy |
| Sigma-Aldrich | E2750 | (+)-Pseudoephedrine hydrochloride ≥98% | 345-78-8 | 25g | $141 | 2026-04-30 | Buy |
| Sigma-Aldrich | HPA003425 | Anti-TFF1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 345-78-8 | 100μL | $607 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP413 | Pseudoephedrine hydrochloride British Pharmacopoeia (BP) Reference Standard | 345-78-8 | 100MG | $270 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1581005 | Pseudoephedrine hydrochloride United States Pharmacopeia (USP) Reference Standard | 345-78-8 | 125mg | $412 | 2026-04-30 | Buy |
(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties, Uses, Production
Chemical Properties
white powder
Uses
Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
brand name
Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Biological Activity
Trefoil factor 1 is a protein encoded by the TFF1 gene in humans. The proteins are small secretory proteins characterized by three intra-chain disulfide bonds forming the trefoil motif or P-domain. It is abundantly expressed on mucosal surfaces and especially within the gastrointestinal tract. The protein belongs to highly conserved proteins th at play an essential role in epithelial regeneration within the gastrointestinal tract. Its expression is strongly induced after mucosal injury and may function as a gastric tumor suppressor gene. It is expressed in various types of carcinomas including breast cancer. The gene contains an estrogen response element and its expression can be regulated by estrogen. Increased expression of this gene is found to be associated with tumor progression in some tumors and missense mutations in the gene have been detected in gastric cancer.
Contact allergens
This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical Use
Nasal decongestant
Drug interactions
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular
arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with
linezolid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with
selegiline and rasagiline.
Metabolism
A small amount of pseudoephedrine is hepatically
metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small
amounts of its hepatic metabolite.
Purification Methods
1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]
(1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
345-78-8 ((1S,2S)-(+)-Pseudoephedrine hydrochloride) Related Search:
1of4
