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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Structure
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol structure
CAS No.
112068-01-6
Chemical Name:
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
Synonyms
(S)-DIPHENYLPROLINOL;(S)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;SDPP;(S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL;Diphenyl(2-pyrrolidinyl)methanol;ALPHA,ALPHA-DIPHENYL-L-PROLINOL;(S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE;alpha,alpha-Diphenyl;Nebivolol Impurity 49;Dextrodiphenylprolinol
CBNumber:
CB5178203
Molecular Formula:
C17H19NO
Molecular Weight:
253.34
MDL Number:
MFCD00075506
MOL File:
112068-01-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:07:29
Product description Number Pack Size Price
(S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 368199 1g $28.5
(S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 368199 5g $99.4
(S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) D2735 1g $47
(S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) D2735 5g $223
(S)-1,1-Diphenylprolinol TRC-D462710-500MG 500mg $78
More product size
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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Properties

Melting point 77-80 °C(lit.)
alpha -59 º (c=3, methanol 25 ºC)
Boiling point 396.54°C (rough estimate)
Density 1.0078 (rough estimate)
refractive index -66.5 ° (C=3, CHCl3)
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in chloroform.
form powder
pka 13.15±0.29(Predicted)
color white to off white ., crystal
optical activity [α]20/D 67°, c = 3 in chloroform
Merck 14,155
BRN 17103
InChI 1S/C17H19NO/c19-17(16-12-7-13-18-16,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16,18-19H,7,12-13H2/t16-/m0/s1
InChIKey OGCGXUGBDJGFFY-INIZCTEOSA-N
SMILES OC([C@@H]1CCCN1)(c2ccccc2)c3ccccc3
CAS DataBase Reference 112068-01-6(CAS DataBase Reference)
FDA UNII K3HE3KC32M
NIST Chemistry Reference S-(-)-1,1-diphenylprolinol(112068-01-6)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25-36
WGK Germany  3
F  10-34
TSCA  No
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 368199 (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 112068-01-6 1g $28.5 2026-04-30 Buy
Sigma-Aldrich 368199 (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 112068-01-6 5g $99.4 2026-04-30 Buy
TCI Chemical D2735 (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) 112068-01-6 1g $47 2026-04-30 Buy
TCI Chemical D2735 (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) 112068-01-6 5g $223 2026-04-30 Buy
TRC TRC-D462710-500MG (S)-1,1-Diphenylprolinol 112068-01-6 500mg $78 2026-06-03 Buy
Product number Packaging Price Buy
368199 1g $28.5 Buy
368199 5g $99.4 Buy
D2735 1g $47 Buy
D2735 5g $223 Buy
TRC-D462710-500MG 500mg $78 Buy

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Uses,Production

Chemical Properties

white to beige crystals or crystalline powder

Uses

suzuki reaction

Uses

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Application

(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (DPPM) may be used in the following processes:

  • DPPM reacts with catecholborane to form a spiroborate ester, which can be an efficient catalyst for the synthesis of enantiopure alcohols by borane reduction of acetophenone.
  • The catalyst generated in situ by reacting DPPM with borane-diethylaniline, can efficiently catalyze the enantioselective reduction of 2′-fluoroacetophenone.
  • Mesoporous SBA-15 silica functionalized with DPPM can catalyze the addition of diethylzinc to benzaldehyde to form (S)-1-phenyl-propanol.
Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Preparation

Into a four-necked flask, add tetrahydrofuran, L-proline methyl ester hydrochloride, and phenyl magnesium chloride （dissolved in tetrahydrofuran) solution was added dropwise from a constant pressure dropping funnel, and the addition was completed in about 4 hours, and then stirred at 10-15°C for 3 hours. Add water, adjust the pH to 5-6 with 10% ammonium chloride aqueous solution, extract with dichloromethane, extract the aqueous layer twice with dichloromethane each time, and obtain the organic phase. Wash once with saturated sodium chloride aqueous solution. The organic phase was dried with anhydrous sodium sulfate for 4 hours and filtered. The obtained organic phase was distilled under reduced pressure to distill dichloromethane and tetrahydrofuran to obtain light yellow oily (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, yield 86.6%.
(S)-( )-α,α-Diphenyl-2-pyrrolidinemethanol

General Description

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is a bifunctional organocatalyst.

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

Phenylmagnesium bromide Ethyl formate L-Proline Tetrahydrofuran

Preparation Products

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Suppliers

Global( 524)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14036 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
China Synchem Technology Co.,Ltd. 		+86-0552-4929304 +86-18055277008 wangxuhui1985@126.com China 65 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Shanghai UCHEM Inc. 		+86-18930848214 +86-021-56762820 sales@myuchem.com China 8898 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
China Synchem Technology Co.,Ltd. 		55
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
Shanghai UCHEM Inc. 		58

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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Spectrum

(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)1HNMR(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)Raman(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)IR

112068-01-6((S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol)Related Search:

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-O-TOLYL-CBS-OXAZABOROLIDINE, 0.5M I& (S)-(-)-ALPHA,ALPHA-DI(2-NAPHTHYL)-2-PYRROLIDINEMETHANOL (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE (S)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (S)-Phenyl oxazaborolidine
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol L-(+)-Prolinol (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-2-METHYL-CBS-OXAZABOROLIDINE (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
(S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilanyloxy)methyl]pyrrolidine, (S)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)trimethylsilyloxy)methyl]pyrrolidine, (S)-α,α-[3,5-Bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether (S)-ALPHA,ALPHA-BIS(4-METHYLPHENYL)-2-PYRROLIDINEMETHANOL (S)-2-(Methoxydiphenylmethyl)pyrrolidine (S)-ALPHA,ALPHA-BIS(4-METHOXYPHENYL)-2-PYRROLIDINEMETHANOL
(2S)-(4,4'-DIISOBUTYLPHENYL)PYRROLIDINE METHANOL SULFATE (S)-(-)-2-[Bis(3,5-dimethylphenyl)hydroxymethyl]pyrrolidine (S,S)-(+)-2,6-BIS[2-(HYDROXYDIPHENYLMETHYL)-1-PYRROLIDINYL-METHYL]-4-METHYLPHENOL

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(S)-(-)-ɑ,ɑ-Diphenylprolinol, 98% (S)-2-(Hydroxydiphenylmethyl)pyrrolidine alpha,alpha-diphenyl-L-proline (S)-α,α-Diphenyl-2-pyrrolidinemethanol, (S)-2-(Diphenylhydroxymethyl)pyrrolidine (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine, α,α-Diphenyl-L-prolinol (S)-(-)-Alpha,alpha-diphenyl-2-pyrrolidin emethanol, 99+% (2S)-α,α-Diphenyl-2-pyrrolidinemethanol (2S)-α,α-Diphenyl-2α-pyrrolidinemethanol (2S)-α,α-Diphenylpyrrolidine-2α-methanol [(2S)-Pyrrolidine-2-yl]diphenylmethanol Diphenyl[(2S)-2-pyrrolidinyl]methanol (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol ,98% (S)-()-α,α-Diphenyl-2-pyrrolidinemethanol,(S)-()-2-(Diphenylhydroxymethyl)pyrrolidine, α,α-Diphenyl-L-prolinol alpha,alpha-Diphenyl (S)-|á,|á-Diphenyl-2-pyrrolidinemethanol (S)-(-)-alpha,alpha-alpha,alpha-diphenyl-2-pyrrolidine methanol (a,a-Diphenyl-L-prolinol) (S)-A,A-DIPHENYL-2-PYRROLIDINE METHANOL (S)-(-)-A,A-DIPHENYLPROLINOL (S)-1-DIPHENYL-PROLINOL (S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE (S)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE (S)-(-)-ALPHA,ALPHA-DIPHENYLPROLINOL (S)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL (S)-(-)-DIPHENYL-2-PYRROLIDINEMETHANOL (S)-(-)-DIPHENYLPYRROLIDINEMETHANOL DIPHENYL-L-PYRROLIDIN-2-YL-METHANOL 2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-, (2S)- (-)-ALPHA,ALPHA-DIPHENYL-L-PROLINOL ALPHA,ALPHA-DIPHENYL-L-PROLINOL A,A-DIPHENYL-L-PROLINOL (s)-(-)-à,à-diphenyl-2-pyrrolidinemethanol (s)-(-)-à,à-diphenylprolinol α,α-diphenyl-l-prolinol 2,2-DIPHENYL-(2S)-2-PYRROLIDINEMETHANOL (S)-(-)-alpha,alpha-diphenyl-2-pyrrolidine (S)-(-)-ALPHA ALPHA-DIPHENYL-2- PYRROLIDINEMETHANOL 99% 2-PYRROLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, (2S)- (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-L-prolinol (S)-Alpha,alpha-diphenyl-l-prolinol (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidineMethanol, 99+% 1GR (S)-()-α,α-Diphenyl-2-pyrrolidineMethanol 99% (S)-(-)-alpha,alpha-Diphenyl-2-rrolidine Methanol (S)-(-)-ALPHA, ALPHA-DIPHENYI-2-PYRROLIDINE METHANOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-()-α,α-Diphenyl-2-pyrrolidinemethanol, >=99% (S)-1,1-Diphenylprolinol (S)-α,α-Diphenyl-2-pyrrolidinemethanol,99%e.e. (S)-(-)-α,α-Diphenylprolinol for synthesis 2-Pyrrolidinemethanol, α,α-diphenyl-, (2S)- (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol> (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-(-)- α,α-Diphenylprolinol (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol USP/EP/BP (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-L- Dextrodiphenylprolinol Nebivolol Impurity 49 TIANFU-CHEM CAS:112068-01-6 alpha,alpha-Diphenyl-L-prolinol diphenyl((S)-pyrrolidin-2-yl)methanol