N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine
![N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine Structure](CAS/20180713/GIF/573678-04-3.gif)
- CAS No.
- 573678-04-3
- Chemical Name:
- N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine
- Synonyms
- NGD8243;NGD 8243;NGD-8243;NGD-8243, 10 mM in DMSO;N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine;4-Quinazolinamine, N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)-2-pyridinyl]-
- CBNumber:
- CB14200883
- Molecular Formula:
- C21H12F6N4
- Molecular Weight:
- 434.34
- MDL Number:
- MFCD18651674
- MOL File:
- 573678-04-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 500.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.440±0.06 g/cm3(Predicted) |
| pka | 4.73±0.30(Predicted) |
| FDA UNII | K3S4K8ACHE |
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0603049 | MK-2295 98% | 573678-04-3 | 1mg | $401 | 2026-06-04 | Buy |
| ChemScene | CS-0603049 | MK-2295 98% | 573678-04-3 | 5mg | $905 | 2026-06-04 | Buy |
| ChemScene | CS-0603049 | MK-2295 98% | 573678-04-3 | 10mg | $1338 | 2026-06-04 | Buy |
| aablocks | AA0249OT | NGD-8243 | 573678-04-3 | 1mg | $176 | 2026-06-01 | Buy |
| aablocks | AA0249OT | NGD-8243 | 573678-04-3 | 5mg | $370 | 2026-06-01 | Buy |
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine Chemical Properties, Uses, Production
Uses
MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain[1][2].
IC 50
TRPV1
References
[1] Gunthorpe MJ, et al. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009 Jan;14(1-2):56-67. DOI:10.1016/j.drudis.2008.11.005
[2] Arthur Gomtsyan, et al. Chapter 8 - Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents. TRP Channels as Therapeutic Targets. From Basic Science to Clinical Use. 2015, Pages 129-144.
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
