tert-Butyl N-(4-formylbenzyl)carbamate
- CAS No.
- 156866-52-3
- Chemical Name:
- tert-Butyl N-(4-formylbenzyl)carbamate
- Synonyms
- tert-butyl 4-formylbenzylcarbamate;4-[(Boc-amino)methyl]benzaldehyde;N-Boc-4-(Aminomethyl)benzaldehyde;tert-Butyl N-(4-formylbenzyl)carbamate;4-(N-TERTBUTOXYAMINOMETHYL)BENZALDEHYDE;4-(Aminomethyl)benzaldehyde, N-BOC protected;(4-formyl-benzyl)-carbamic acid t-butyl ester;Tert-butylN-[(4-formylphenyl)methyl]carbamate;(4-Formylbenzyl)carbamic acid tert-butyl ester;tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Bu
- CBNumber:
- CB1450169
- Molecular Formula:
- C13H17NO3
- Molecular Weight:
- 235.28
- MDL Number:
- MFCD06659090
- MOL File:
- 156866-52-3.mol
- MSDS File:
- SDS
| Melting point | 83 °C |
|---|---|
| Boiling point | 389.0±25.0 °C(Predicted) |
| Density | 1.108±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystalline powder |
| pka | 11.92±0.46(Predicted) |
| color | Pale yellow |
| CAS DataBase Reference | 156866-52-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P271-P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-51 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 2922390090 | |||||||||
| NFPA 704 |
|
tert-Butyl N-(4-formylbenzyl)carbamate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB139436 | tert-Butyl 4-formylbenzylcarbamate | 156866-52-3 | 500mg | $150 | 2026-06-04 | Buy |
| Biosynth | FB139436 | tert-Butyl 4-formylbenzylcarbamate | 156866-52-3 | 250mg | $150 | 2026-06-04 | Buy |
| Biosynth | FB139436 | tert-Butyl 4-formylbenzylcarbamate | 156866-52-3 | 1000mg | $200 | 2026-06-04 | Buy |
| Biosynth | FB139436 | tert-Butyl 4-formylbenzylcarbamate | 156866-52-3 | 2000mg | $280 | 2026-06-04 | Buy |
| Biosynth | FB139436 | tert-Butyl 4-formylbenzylcarbamate | 156866-52-3 | 500000mg | $10000 | 2026-06-04 | Buy |
tert-Butyl N-(4-formylbenzyl)carbamate Chemical Properties,Uses,Production
Synthesis
123986-64-1
156866-52-3
General procedure for the synthesis of tert-butyl 4-formylbenzylcarbamate from tert-butyl 4-(hydroxymethyl)benzylcarbamate: tert-butyl 4-(hydroxymethyl)benzylcarbamate (2.20 g, 9.2 mmol) was dissolved in dichloromethane (DCM, 100 ml), and manganese dioxide (MnO2, 8.18 g, 92 mmol, 10 equiv) was added. The resulting suspension was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to afford tert-butyl 4-formylbenzylcarbamate as a white solid (2.18 g, 9.2 mmol, 100% yield). Thin layer chromatography (TLC) analysis showed Rf = 0.62 (Expander: DCM/ethyl acetate, 9:1). Infrared spectroscopy (IR) showed characteristic absorption peaks. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ = 10.0 (s, 1H, CHO), 7.85 (d, J = 8.1 Hz, 2H, ArCH adjacent to CHO), 7.45 (d, J = 8.1 Hz, 2H, ArCH adjacent to CH2NHBoc), 4.99 (bs. 1H, NHBoc), 4.40 (d, J = 5.7 Hz, 2H, CH2NHBoc), 1.47 (s, 9H, C(CH3)3). Nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) δ = 191.9 (CHO), 155.9 (CO), 145.9 (ArCCH2NHBoc), 135.5 (ArCCHO), 130.1 (ArCH adjacent to CHO), 127.6 (ArCH adjacent to CH2NHBoc), 85.1 (C(CH3)3), 44.3 (CH2NHBoc), 28.3 (C(CH3)3). High-resolution mass spectrometry (HRMS, ESI+) showed an m/z of 258.1101 (calculated value: C13H19NO3Na [M+Na]+, 258.1101; measured value: 258.1094). The NMR data are consistent with literature reports.
References
[1] Patent: WO2012/95628, 2012, A1. Location in patent: Page/Page column 18-19
[2] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 148
[3] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 53
[4] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[5] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63
tert-Butyl N-(4-formylbenzyl)carbamate Preparation Products And Raw materials
tert-Butyl N-(4-formylbenzyl)carbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2283 | 55 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1997 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
View Lastest Price from tert-Butyl N-(4-formylbenzyl)carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-01 | TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
156866-52-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
156866-52-3
- $1.00
- 99%
- Career Henan Chemical Co
156866-52-3(tert-Butyl N-(4-formylbenzyl)carbamate)Related Search:
1of4
