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3,3,3-Trifluoropropionic acid

3,3,3-Trifluoropropionic acid Structure
3,3,3-Trifluoropropionic acid structure
CAS No.
2516-99-6
Chemical Name:
3,3,3-Trifluoropropionic acid
Synonyms
TFPA;cas no.:2516-99-6;RARECHEM AL BE 1046;Trifluoropropionicacid;TFPA 98% cas no 2516-99-6;Trifluoromethylacetic acid;3,3,3-TRIFLUOROPROPANOICACID;3,3,3-TRIFLUOROPROPIONIC ACID;3,3,3-Trifluoropropionnic acid;3,3,3-tri fluoropropaonic acid
CBNumber:
CB1451050
Molecular Formula:
C3H3F3O2
Molecular Weight:
128.05
MDL Number:
MFCD00153292
MOL File:
2516-99-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:36:12
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3,3,3-Trifluoropropionic acid Properties

Melting point 9.7 °C (lit.)
Boiling point 145 °C/746 mmHg (lit.)
Density 1.45 g/mL at 25 °C (lit.)
refractive index n20/D 1.333(lit.)
Flash point >100°C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka pK1:3.06 (25°C)
form Liquid
color Clear colorless
BRN 1751796
InChI InChI=1S/C3H3F3O2/c4-3(5,6)1-2(7)8/h1H2,(H,7,8)
InChIKey KSNKQSPJFRQSEI-UHFFFAOYSA-N
SMILES C(O)(=O)CC(F)(F)F
CAS DataBase Reference 2516-99-6(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H412
Precautionary statements  P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
Hazard Note  Corrosive
HazardClass  8
PackingGroup  II
HS Code  29159000
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Inhalation
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1A
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
2
3 0

3,3,3-Trifluoropropionic acid price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 498203 3,3,3-Trifluoropropionic acid 98% 2516-99-6 5ml $178 2026-04-30 Buy
Sigma-Aldrich 498203 3,3,3-Trifluoropropionic acid 98% 2516-99-6 25ml $751 2026-04-30 Buy
TCI Chemical T1713 3,3,3-Trifluoropropionic Acid >98.0%(GC)(T) 2516-99-6 1g $23 2026-04-30 Buy
TCI Chemical T1713 3,3,3-Trifluoropropionic Acid >98.0%(GC)(T) 2516-99-6 5g $63 2026-04-30 Buy
AstaTech 66732 3,3,3-TRIFLUORO-PROPIONIC ACID 97% 2516-99-6 5G $87 2026-04-30 Buy
Product number Packaging Price Buy
498203 5ml $178 Buy
498203 25ml $751 Buy
T1713 1g $23 Buy
T1713 5g $63 Buy
66732 5G $87 Buy

3,3,3-Trifluoropropionic acid Chemical Properties,Uses,Production

Chemical Properties

Clear colorless liquid

Uses

3,3,3-Trifluoropropionic acid may be used in the synthesis of:

  • 2,2,2-trifluoroethyl 3,3,3-trifluoroprionate
  • ethyl 3,3,3-trifluoroprionate
  • N-trifluoropropionyl-D-mannosamine
  • 3,3,3-trifluoropropanoyl chloride

Synthesis

3,3,3-Trifluoropropionic acid can be reduced to trifluoropropanal or trifluoropropanol by lithium aluminum hydride or sodium borohydride, or it can be reduced to trifluoropropanol by hydrogenation in the presence of Rh/C catalyst. The CF3 group of 3,3,3-trifluoropropionic acid is unstable and susceptible to hydrolysis under strong alkaline conditions, so 3,3,3-trifluoropropionic acid cannot be obtained by hydrolysis of trifluoropropionic acid esters under alkaline conditions, but can be prepared by hydrolysis under acidic conditions.

3,3,3-Trifluoropropionic acid synthesis

460-40-2
2516-99-6
Synthesis of 3,3,3-Trifluoropropionic acid from 3,3,3-Trifluoropropanal

3,3,3-Trifluoropropionic acid Preparation Products And Raw materials

Raw materials

Phosphorus oxybromide 2,2,2-Trifluoroethanol Carbon dioxide Diethyl ether 2-Iodo-1,1,1-trifluoroethane
Phosphorus tribromide Magnesium

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Preparation Products

3,3,3-Trifluoropropanoic anhydride N-(3,3,3-trifluoropropyl)aniline

3,3,3-Trifluoropropionic acid Suppliers

Global( 334)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD 571-89189769 15168342188 China 228 62
Yangzhou modier Electronic Materials Co., Ltd 13761402923 19975033992 market@modeltemol.com China 7830 58
shanghai sinofluoro chemicals co., ltd. 15800445152 sales@sinofluoro.com China 298 59
Hangzhou Cedareal Technology Co., Ltd. 13858087543 368073698@qq.com China 46 58
Shanghai Furui Pharmaceutical Technology Co., Ltd 18018698069 sales@fluororing.com China 79 58
jinanzhonglanhuagongyouxiangongsi 15169176553; 15169176553 644658103@qq.com China 32 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD 62
Yangzhou modier Electronic Materials Co., Ltd 58
shanghai sinofluoro chemicals co., ltd. 59
Hangzhou Cedareal Technology Co., Ltd. 58
Shanghai Furui Pharmaceutical Technology Co., Ltd 58
jinanzhonglanhuagongyouxiangongsi 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from 3,3,3-Trifluoropropionic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,3,3-Trifluoropropionic acid pictures 2026-08-25 3,3,3-Trifluoropropionic acid
2516-99-6
 $55.00-550.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
3,3,3-Trifluoropropionic acid pictures 2025-04-04 3,3,3-Trifluoropropionic acid
2516-99-6
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
3,3,3-Trifluoropropanoic acid pictures 2023-07-19 3,3,3-Trifluoropropanoic acid
2516-99-6
 $30.00 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd

3,3,3-Trifluoropropionic acid Spectrum

3,3,3-Trifluoropropionic acid(2516-99-6)1HNMR3,3,3-Trifluoropropionic acid(2516-99-6)IR

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RARECHEM AL BE 1046 Trifluoromethylacetic acid 3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-Trifluoropropionic acid 98% 3,3,3-Trifluoropropionicacid98% 3,3,3-TRIFLUOROPROPANOICACID propanoic acid, 3,3,3-trifluoro- 3,3,3-Trifluoropropionnic acid 3,3,3-Trifluoropropionic acid ,95% 3,3,3-Trifluoropropanoic acid 98% Trifluoropropionicacid 3,3,3-tri fluoropropaonic acid 3,3,3-Trifluoropropionic acid, (Trifluoromethyl)acetic acid cas no.:2516-99-6 3,3,3-Trifluoropropionic acid 98%,cas:2516-99-6 3,3,3-Trifluoropropionic acid 98%, cas no.:2516-99-6 TFPA 98% cas no 2516-99-6 Trifluoromethylacetic acid 98% cas no 2516-99-6 3,3,3-TRIFLUOROPROPANOICACID 98% cas no 2516-99-6 propanoic acid, 3,3,3-trifluoro- 98% cas no 2516-99-6 3,3,3-Trifluoropropionnic acid 98% cas no 2516-99-6 Trifluoropropionicacid 98% cas no 2516-99-6 3,3,3-tri fluoropropaonic acid 98% cas no 2516-99-6 TFPA 2516-99-6 2516-99-9 2156-99-6 CF3CH2CO2H C3H2F3O2 CARBOXYLIC ACID Organic Building Blocks Carbonyl Compounds Carboxylic Acids C1 to C5 Building Blocks C1 to C5 Carbonyl Compounds Carboxylic Acids Fluorochemicals