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CHF-5022

CHF-5022 structure

CAS No.: 749269-77-0

Chemical Name:: CHF-5022

Synonyms: CHF-5022;CHEMBL196246;UNII-JO8EVV007Q;Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

CBNumber:: CB14919701

Molecular Formula:: C17H12F4O2

Molecular Weight:: 324.27

MDL Number:

MOL File:: 749269-77-0.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:41

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CHF-5022 Properties

Boiling point	405.8±45.0 °C(Predicted)
Density	1.403±0.06 g/cm3(Predicted)
pka	3.29±0.20(Predicted)
FDA UNII	JO8EVV007Q

CHF-5022 Chemical Properties, Uses, Production

Uses

CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (22.2±4.8% at 100 μM)[1].

in vivo

After multiple oral administration, CHF5022 is absorbed dose-dependently, with a fair penetration of the brain (≈10%) of young Tg2575 mice^[1].

References

[1] Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. DOI:10.1016/j.phrs.2006.12.010

CHF-5022 Preparation Products And Raw materials

Raw materials

Preparation Products

CHF-5022 Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2994	55
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
BOC Sciences	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

749269-77-0 (CHF-5022) Related Search:

Pyridoxal phosphate Amyloid β-Protein (1-42) (mouse, rat) Research Grade Trontinemab (DHC12508) Lecanemab (Mouse IGG2a) Amyloid β-Peptide (1-42) (human)

Cromolyn Disodium Salt

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CHF-5022 CHEMBL196246 UNII-JO8EVV007Q Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- 749269-77-0