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Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate structure

CAS No.: 154825-97-5

Chemical Name:: Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Synonyms: methyl 2-(4-bromophenyl)-2-methylpropanoate;2-DIMETHYLACETATE;METHYL 2-(4-BROMOPHENYL)-2;P-Bromo-a,a-DimethylPhenylacetic;2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE;P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC;P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster;2-(4-bromophenyl)-2-methyl-propionicacidmethyle;Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate;α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester

CBNumber:: CB1500840

Molecular Formula:: C11H13BrO2

Molecular Weight:: 257.12

MDL Number:: MFCD02683357

MOL File:: 154825-97-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:49:17

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Methyl 2-(4-bromophenyl)-2,2-dimethylacetate Properties

Boiling point	290℃
Density	1.337
vapor pressure	0.001Pa at 40℃
Flash point	129℃
storage temp.	Sealed in dry,Room Temperature
solubility	Acetonitrile (Slightly), Chloroform (Slightly)
form	Oil
color	Clear Colorless to Pale Yellow
Water Solubility	43mg/L at 20℃
InChI	InChI=1S/C11H13BrO2/c1-11(2,10(13)14-3)8-4-6-9(12)7-5-8/h4-7H,1-3H3
InChIKey	JTYDXPPFLQSEAQ-UHFFFAOYSA-N
SMILES	C1(C=CC(Br)=CC=1)C(C)(C)C(=O)OC
LogP	3.73 at 22℃
CAS DataBase Reference	154825-97-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H412
Precautionary statements	P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
REACH Registrations	Active

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-M294390-5G	Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate	154825-97-5	5g	$326	2026-06-03	Buy
TRC	TRC-M294390-2G	Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate	154825-97-5	2g	$205	2026-06-03	Buy
TRC	TRC-M294390-1G	Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate	154825-97-5	1g	$123	2026-06-03	Buy
Activate Scientific	AS32270	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 98%	154825-97-5	5g	$18	2026-06-04	Buy
Activate Scientific	AS32270	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 98%	154825-97-5	25g	$29	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-M294390-5G	5g	$326	Buy
TRC-M294390-2G	2g	$205	Buy
TRC-M294390-1G	1g	$123	Buy
AS32270	5g	$18	Buy
AS32270	25g	$29	Buy

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate Chemical Properties, Uses, Production

Chemical Properties

Colourless Oil

Uses

Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Synthesis

41841-16-1

74-88-4

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

154825-97-5

Sodium hydride (60% oil dispersion, 192 mg, 4.80 mmol) was added to dry DMF (11 mL) at 0 °C to form a suspension. Subsequently, methyl 2-(4-bromophenyl)acetate (0.35 mL, 2.2 mmol) was slowly added to this suspension. After the reaction mixture was stirred continuously for 15 min at 0 °C, iodomethane (6.5 μL, 0.10 mmol) was added dropwise. After addition, stirring was continued at 0 °C for 5 min, and then raised to room temperature and stirred for 12 hours. After completion of the reaction, the reaction was quenched with 1N HCl aqueous solution (1 mL) and extracted with ethyl acetate (3 × 2 mL). The organic layers were combined, washed sequentially with water (3 × 2 mL) and saturated saline (2 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: 0% to 5% ethyl acetate/hexane gradient elution) to afford the target product methyl 2-(4-bromophenyl)-2-methylpropionate (550 mg, 98% yield); mass spectrometry (electrospray positive ionization mode) C10H11BrO2 Calculated value: 242/244, measured value: 243/245 [M+H]+.

References

[1] Patent: WO2014/31928, 2014, A2. Location in patent: Paragraph 0398
[2] Patent: WO2010/86820, 2010, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 24
[4] Patent: US2008/21024, 2008, A1. Location in patent: Page/Page column 80
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 5, p. 998 - 1005

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate Preparation Products And Raw materials

Raw materials

Methanol Methyl 4-bromophenylacetate 2-(4-BroMo-phenyl)-propionic acid Methyl ester tert-Butyl methyl ether 2-(4-Bromophenyl)-2-methylpropionic acid

Iodomethane Mineral oil Sodium hydride N,N-Dimethylformamide

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Preparation Products

4-(4-Hydroxy-1-butynl)-α,α-dimethylbenzeneacetic acid, methyl ester

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate Suppliers

Global Suppliers ( 165)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Huaweisite Pharmaceutical Technology Co., Ltd.	0519-88721112	supporting@harvechem.com	China	84	58
Nanjing Endesa Bio-tech Co., Ltd.	025-58862853 18915922038	sales@endesachem.com	China	590	58
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Jiangxi Jingyang Chemical Products Co., LTD	0798-15170312128 15170312128	1436027029@qq.com	China	16	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	15995069468 15995069468	3398435160@qq.com	China	298	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Jiangsu Huaweisite Pharmaceutical Technology Co., Ltd.	58
Nanjing Endesa Bio-tech Co., Ltd.	58
Anhui Dexinjia Biopharm Co., Ltd	58
Jiangxi Jingyang Chemical Products Co., LTD	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
ChemFuture PharmaTech (Jiangsu) Ltd	65
Energy Chemical	61
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from Methyl 2-(4-bromophenyl)-2,2-dimethylacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-30	Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate 154825-97-5	$10.00-150.00	1kg	NLT98%	2 ton per month	Anhui Dexinjia Biopharm Co., Ltd
2022-02-09	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 154825-97-5		1KG	98.2%	100 tons	Honest Joy Holdings Limited
2021-07-02	METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE 154825-97-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate
154825-97-5
$10.00-150.00
NLT98%
Anhui Dexinjia Biopharm Co., Ltd

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5
$0.00
98.2%
Honest Joy Holdings Limited

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE
154825-97-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate Spectrum

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE(154825-97-5)¹HNMR

154825-97-5 (Methyl 2-(4-bromophenyl)-2,2-dimethylacetate) Related Search:

N/A Dimethylphenylsilane Dimethyl phenylphosphonite tert-Butyl 2-(4-bromophenyl)-2-methylpropionate Methyl 2-(4-bromophenyl)-2,2-di-(methyl-d3)acetate

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 4-Bromophenylacetic acid 2-(4-Bromophenyl)-2-methylpropionic acid

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Benzeneacetic acid,4-broMo-a,a-diMethyl-, Methyl ester Benzeneacetic acid, 4-bromo-α,α-dimethyl-, methyl ester 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Alf Alda di methyl Para Bromo phenyl acetic acid methyl ester p-Bromo-alpha,alpha-Dimethylphenylacetic acid methyl ester 2-methyl-2-(p-bromophenyl)propionic acid methyl ester P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster P-Bromo-a,a-DimethylPhenylacetic P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester 2-(4-bromophenyl)-2-methyl-propionicacidmethyle 2-DIMETHYLACETATE METHYL 2-(4-BROMOPHENYL)-2 Alfa, Alfa Di Methyl Para Bromo Phenyl Acetic Acid Methyl Ester Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate methyl 2-(4-bromophenyl)-2-methylpropanoate 154825-97-5 Intermediates Miscellaneous Reagents Aromatics Compounds Aromatics