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METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE structure

CAS No.: 154825-97-5

Chemical Name:: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

Synonyms: methyl 2-(4-bromophenyl)-2-methylpropanoate;2-DIMETHYLACETATE;METHYL 2-(4-BROMOPHENYL)-2;P-Bromo-a,a-DimethylPhenylacetic;2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE;P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC;P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster;2-(4-bromophenyl)-2-methyl-propionicacidmethyle;Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate;α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester

CBNumber:: CB1500840

Molecular Formula:: C11H13BrO2

Molecular Weight:: 257.12

MDL Number:: MFCD02683357

MOL File:: 154825-97-5.mol

Last updated:2025-08-08 17:45:00

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METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Properties

Boiling point	290℃
Density	1.337
vapor pressure	0.001Pa at 40℃
Flash point	129℃
storage temp.	Sealed in dry,Room Temperature
solubility	Acetonitrile (Slightly), Chloroform (Slightly)
form	Oil
color	Clear Colorless to Pale Yellow
Water Solubility	43mg/L at 20℃
InChI	InChI=1S/C11H13BrO2/c1-11(2,10(13)14-3)8-4-6-9(12)7-5-8/h4-7H,1-3H3
InChIKey	JTYDXPPFLQSEAQ-UHFFFAOYSA-N
SMILES	C1(C=CC(Br)=CC=1)C(C)(C)C(=O)OC
LogP	3.73 at 22℃
CAS DataBase Reference	154825-97-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H412
Precautionary statements	P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M294390	Methyl2-(4-Bromophenyl)-2,2-dimethylacetate	154825-97-5	1g	$95	2021-12-16	Buy
Matrix Scientific	074052	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 95+%	154825-97-5	10g	$165	2021-12-16	Buy
AK Scientific	W3377	Methyl2-(4-bromophenyl)-2,2-dimethylacetate	154825-97-5	1g	$14	2021-12-16	Buy
AK Scientific	J98988	Methyl2-(4-bromophenyl)-2,2-dimethylacetate	154825-97-5	100g	$230	2021-12-16	Buy
Matrix Scientific	074052	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 95+%	154825-97-5	1g	$43	2021-12-16	Buy

Product number	Packaging	Price	Buy
M294390	1g	$95	Buy
074052	10g	$165	Buy
W3377	1g	$14	Buy
J98988	100g	$230	Buy
074052	1g	$43	Buy

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Chemical Properties,Uses,Production

Chemical Properties

Colourless Oil

Uses

Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Synthesis

41841-16-1

74-88-4

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

154825-97-5

Sodium hydride (60% oil dispersion, 192 mg, 4.80 mmol) was added to dry DMF (11 mL) at 0 °C to form a suspension. Subsequently, methyl 2-(4-bromophenyl)acetate (0.35 mL, 2.2 mmol) was slowly added to this suspension. After the reaction mixture was stirred continuously for 15 min at 0 °C, iodomethane (6.5 μL, 0.10 mmol) was added dropwise. After addition, stirring was continued at 0 °C for 5 min, and then raised to room temperature and stirred for 12 hours. After completion of the reaction, the reaction was quenched with 1N HCl aqueous solution (1 mL) and extracted with ethyl acetate (3 × 2 mL). The organic layers were combined, washed sequentially with water (3 × 2 mL) and saturated saline (2 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: 0% to 5% ethyl acetate/hexane gradient elution) to afford the target product methyl 2-(4-bromophenyl)-2-methylpropionate (550 mg, 98% yield); mass spectrometry (electrospray positive ionization mode) C10H11BrO2 Calculated value: 242/244, measured value: 243/245 [M+H]+.

References

[1] Patent: WO2014/31928, 2014, A2. Location in patent: Paragraph 0398
[2] Patent: WO2010/86820, 2010, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 24
[4] Patent: US2008/21024, 2008, A1. Location in patent: Page/Page column 80
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 5, p. 998 - 1005

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Preparation Products And Raw materials

Raw materials

Methanol Methyl 4-bromophenylacetate 2-(4-BroMo-phenyl)-propionic acid Methyl ester tert-Butyl methyl ether 2-(4-Bromophenyl)-2-methylpropionic acid

Iodomethane Mineral oil Sodium hydride N,N-Dimethylformamide

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Preparation Products

4-(4-HYDROXY-1-BUTYNL)-A,A-DIMETHYLBENZENEACETIC ACID, METHYL ESTER

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	12930	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	299	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1382	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Anhui Dexinjia Biopharm Co., Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-16	Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate 154825-97-5	US $10.00-150.00 / kg	1kg	NLT98%	2 ton per month	Anhui Dexinjia Biopharm Co., Ltd
2022-02-09	Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 154825-97-5	US $0.00 / KG	1KG	98.2%	100 tons	Honest Joy Holdings Limited
2021-07-02	METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE 154825-97-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate
154825-97-5
US $10.00-150.00 / kg
NLT98%
Anhui Dexinjia Biopharm Co., Ltd

Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5
US $0.00 / KG
98.2%
Honest Joy Holdings Limited

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE
154825-97-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Spectrum

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE(154825-97-5)¹HNMR

154825-97-5(METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE)Related Search:

N/A DIMETHYL PHENYLPHOSPHONITE Dimethylphenylsilane 4-Bromophenylacetic acid METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

METHYL 2-(4-BROMOPHENYL)-2,2-DI-(METHYL-D3)ACETATE 2-(4-Bromophenyl)-2-methylpropionic acid TERT-BUTYL 2-(4-BROMOPHENYL)-2-METHYLPROPIONATE

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methyl 2-(4-bromophenyl)-2-methylpropanoate Benzeneacetic acid,4-broMo-a,a-diMethyl-, Methyl ester Benzeneacetic acid, 4-bromo-α,α-dimethyl-, methyl ester 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Alf Alda di methyl Para Bromo phenyl acetic acid methyl ester p-Bromo-alpha,alpha-Dimethylphenylacetic acid methyl ester 2-methyl-2-(p-bromophenyl)propionic acid methyl ester P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster P-Bromo-a,a-DimethylPhenylacetic P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester 2-(4-bromophenyl)-2-methyl-propionicacidmethyle 2-DIMETHYLACETATE METHYL 2-(4-BROMOPHENYL)-2 Alfa, Alfa Di Methyl Para Bromo Phenyl Acetic Acid Methyl Ester Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate 154825-97-5 Intermediates Miscellaneous Reagents Aromatics Compounds Aromatics