Ethyl 2-chloropyrimidine-5-carboxylate
- CAS No.
- 89793-12-4
- Chemical Name:
- Ethyl 2-chloropyrimidine-5-carboxylate
- Synonyms
- EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;Ethyl 2-chloropyrimidine-5-carboxylat;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-Chloro-5-pyrimidinecarboxylate ethyl ester;2-chloro-pyrimidine-5-carboxylic acid ethyl ester
- CBNumber:
- CB1547225
- Molecular Formula:
- C7H7ClN2O2
- Molecular Weight:
- 186.6
- MDL Number:
- MFCD09863164
- MOL File:
- 89793-12-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 52-60℃ |
|---|---|
| Boiling point | 80℃/760mm |
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Solid |
| pka | -3.05±0.22(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3 |
| InChIKey | IEMKQRSOAOPKRJ-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(C(OCC)=O)C=N1 |
| CAS DataBase Reference | 89793-12-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Ethyl 2-chloropyrimidine-5-carboxylate price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1250 | Ethyl 2-Chloropyrimidine-5-carboxylate >98.0%(GC) | 89793-12-4 | 1g | $57 | 2026-04-30 | Buy |
| Usbiological | 164074 | Ethyl 2-Chlorpyrimidine-5-carboxylate | 89793-12-4 | 1g | $403 | 2026-06-03 | Buy |
| ChemScene | CS-W003995 | Ethyl 2-chloropyrimidine-5-carboxylate ≥97% | 89793-12-4 | 1g | $8 | 2026-06-04 | Buy |
| ChemScene | CS-W003995 | Ethyl 2-chloropyrimidine-5-carboxylate ≥97% | 89793-12-4 | 5g | $18 | 2026-06-04 | Buy |
| ChemScene | CS-W003995 | Ethyl 2-chloropyrimidine-5-carboxylate ≥97% | 89793-12-4 | 10g | $24 | 2026-06-04 | Buy |
Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties, Uses, Production
Chemical Properties
White to light yellow liquid
Uses
Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.
Synthesis
A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).
References
[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 34
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 27; 28
[3] Patent: US2009/76006, 2009, A1. Location in patent: Page/Page column 31; 40
[4] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 138-139
[5] Patent: WO2009/36016, 2009, A1. Location in patent: Page/Page column 69
Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou FRIEND Chemical Co., Ltd. | 025-0523-86200082 15380713688 | Austin@fredchem.cn | China | 153 | 55 |
| Zaozhuang Benefit Chemical Co., Ltd. | 0531-69958783 15508681609 | 1948129184@qq.com | China | 207 | 60 |
| Hunan Daolin Biotechnology Co. , Ltd. | 18974846212 | 1876969603@qq.com | China | 57 | 58 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Ethyl 2-chloropyrimidine-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Ethyl 2-chloropyrimidine-5-carboxylate
89793-12-4
|
1kg | 99%HPLC;99%GC | 1ton | Nanjing Fred Technology Co., Ltd | ||
 |
2021-07-02 | ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-05-15 | ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- Ethyl 2-chloropyrimidine-5-carboxylate
89793-12-4
- $0.00
- 99%HPLC;99%GC
- Nanjing Fred Technology Co., Ltd
-
- ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
89793-12-4 (Ethyl 2-chloropyrimidine-5-carboxylate) Related Search:
1of4
