Acibenzolar-S-methyl
- CAS No.
- 135158-54-2
- Chemical Name:
- Acibenzolar-S-methyl
- Synonyms
- BTH;Unix Bion;Actigard;Bendicar;Bion, BTH;cga 245704;ACIDENZOLAR;Actigard AM 87;CAS:135158-54-2;Bion (pesticide)
- CBNumber:
- CB1671847
- Molecular Formula:
- C8H6N2OS2
- Molecular Weight:
- 210.28
- MDL Number:
- MFCD16656987
- MOL File:
- 135158-54-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 134-135℃ |
|---|---|
| Boiling point | 267°C (rough estimate) |
| Density | 1.450 |
| vapor pressure | 4.4 x 10-4 Pa (25 °C) |
| refractive index | 1.5690 (estimate) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), Methanol (Very Slightly) |
| Water Solubility | 7.7 mg l-1 (25 °C) |
| pka | -3.90±0.50(Predicted) |
| form | Solid |
| color | Off-White to Light Beige |
| Henry's Law Constant | 8.3×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Major Application |
agriculture environmental |
| InChI | 1S/C8H6N2OS2/c1-12-8(11)5-3-2-4-6-7(5)13-10-9-6/h2-4H,1H3 |
| InChIKey | UELITFHSCLAHKR-UHFFFAOYSA-N |
| SMILES | CSC(=O)c1cccc2nnsc12 |
| LogP | 3.100 |
| EWG's Food Scores | 1-2 |
| FDA UNII | BCW6119347 |
| Pesticides Freedom of Information Act (FOIA) | Acibenzolar-S-methyl |
| EPA Substance Registry System | Acibenzolar-S-methyl (135158-54-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335-H410 | |||||||||
| Precautionary statements | P273-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-43-50/53 | |||||||||
| Safety Statements | 24/25-37-46-59-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
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| Hazardous Substances Data | 135158-54-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in rats (mg/kg): >2000 orally; >2000 dermally (Ruess) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Acibenzolar-S-methyl price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 32820 | Acibenzolar-S-methyl PESTANAL?, analytical standard | 135158-54-2 | 100mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 24212 | Acibenzolar-S-methyl ≥98% | 135158-54-2 | 5mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 24212 | Acibenzolar-S-methyl ≥98% | 135158-54-2 | 10mg | $240 | 2026-04-30 | Buy |
| ChemScene | CS-0065838 | Acibenzolar-S-methyl ≥98% | 135158-54-2 | 25mg | $60 | 2026-06-04 | Buy |
| ChemScene | CS-0065838 | Acibenzolar-S-methyl ≥98% | 135158-54-2 | 50mg | $97 | 2026-06-04 | Buy |
Acibenzolar-S-methyl Chemical Properties, Uses, Production
Description
Acibenzolar-S-methyl (Novartis) has attracted special attention because it acts against a very wide range of plant diseases but does not directly affect the growth or metabolism of the causal organisms. It is known to act by stimulating systemic activated resistance (SAR) in the treated plant. The well-established compound probenazole, which for some years has been the leading treatment for rice blast in Japan, is thought to act in a similar way. Pathogen resistance to probenazole has not developed, and such stability of performance may well be a general feature of SAR-inducing compounds.
Chemical Properties
Pure product is white to beige powdery solid, and has the odor of burning. m.p. 132.9 ℃, b.p. about 267 ℃, the relative density of 1.54 (20 ℃), the vapor pressure of 4.4 × 10-4Pa (25 ℃). 25 ℃ at the solubility: methanol 4.2g / L, ethyl acetate 25g / L, hexane 1.3g / L, toluene 36g / L, acetone 28g / L, n-octyl alcohol 5.4g / L, dichloromethane 160g / L, water 7.7g / L. Distribution coefficient 3.1 (20 ℃). Octanol 5.4g/L, dichloromethane 160g/L, water 7.7g/L. Partition coefficient 3.1 (20℃). Hydrolysis half-life 3.8 years (20℃, pH=5), 23 weeks (20℃, pH=7), 19.4h (20℃, pH=9).
Uses
Acibenzolar-S-methyl is a S-methyl thioester derivative of acibenzolar. Acibenzolar-S-Methyl acts as a fungicide in pesticidal formulations.
Uses
Plant disease resistance activator.
Uses
CGA245704 is used to control a range of diseases in wheat and it is being developed for use on rice, bananas, vegetables and tobacco.
Production Methods
Acibenzolar-S-methyl is manufactured through a multi-step chemical synthesis that begins with the formation of the 1,2,3-benzothiadiazole core. This heterocyclic ring is created via a classic ring-closure reaction, where a thiol group reacts with an adjacent diazonium group on a benzene ring. The resulting compound, 1,2,3-benzothiadiazole-7-carboxylic acid, is then converted into its S-methyl thioester form through standard chemical transformations, typically involving hydrolysis to the free acid followed by reaction with thionyl chloride to form the acid chloride, and finally methylation with a thiol reagent.
Definition
ChEBI: A benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. It is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes.
Mechanism of action
Systemic Activated Resistance (SAR). Induces host plant defence.
Metabolic pathway
Very little information on the fate of CGA245704 has been published. It is readily degraded in soil and plants and it is rapidly eliminated from animals. A partial metabolic pathway is shown in Scheme 1.
Degradation
CGA245704 is a stable substance and it is very stable in solution other than at high pH values. Its DT50 values (20 °C) at pH 5, 7 and 9 were 3.8 years, 23 weeks and 19 hours, respectively (PM). Hydrolysis of the thioester link and ring opening would be anticipated.
Pesticide Type
Fungicide
Acibenzolar-S-methyl Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Xilong Biochemical Technology Co., Ltd. | 021-52907766-8042 | China | 9928 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Zhejiang Haiqiang Chemical Co.,Ltd | 0571-86050367 0571-86960370 0571-86050387 | info@chinahaiqiangchem.com | China | 461 | 55 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Shanghai BaiShun Biological Technology Co., Ltd | 021-37581181 | sales@chem-mall.com | China | 10314 | 58 |
View Latest Price from Acibenzolar-S-methyl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | ACIBENZOLAR-S-METHYL
135158-54-2
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2025-12-22 | Acibenzolar-S-methyl
135158-54-2
|
$408.00-751.00 | 99.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-02 | 1,2,3-Benzothiadiazole-7-carbothioicacid, S-methyl ester
135158-54-2
|
1kg | 99% | 100ton | Wuhan Xinhao Biotechnology Co., Ltd |
-
- ACIBENZOLAR-S-METHYL
135158-54-2
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Acibenzolar-S-methyl
135158-54-2
- $408.00-751.00
- 99.64%
- TargetMol Chemicals Inc.
-
- 1,2,3-Benzothiadiazole-7-carbothioicacid, S-methyl ester
135158-54-2
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd
