A-18-F-NH2
- CAS No.
- 99588-52-0
- Chemical Name:
- A-18-F-NH2
- Synonyms
- A18Famide;A-18-F-NH2;PubChem ID: 16131005;Morphine Modulating Neuropeptide;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE AMIDE;A-18-F-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;L-Phenylalaninamide, L-alanylglycyl-L-α-glutamylglycyl-L-leucyl-L-seryl-L-seryl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-seryl-L-leucyl-L-alanyl-L-alanyl-L-prolyl-L-glutaminyl-L-arginyl-
- CBNumber:
- CB1682771
- Molecular Formula:
- C89H130N24O24
- Molecular Weight:
- 1920.13
- MDL Number:
- MFCD00076703
- MOL File:
- 99588-52-0.mol
A-18-F-NH2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | M4675-01A | Morphine Modulating Neuropeptide | 99588-52-0 | 1mg | $531 | 2021-12-16 | Buy |
| Usbiological | M4675-01 | Morphine Modulating Neuropeptide | 99588-52-0 | 1mg | $531 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0009156 | A-18-F-NH2 95.00% | 99588-52-0 | 0.5MG | $599.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0009156 | A-18-F-NH2 95.00% | 99588-52-0 | 1MG | $664.13 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb71317 | Morphine Modulating Neuro peptide Greater than 85% affinity purified | 99588-52-0 | 5mg | $425 | 2021-12-16 | Buy |
A-18-F-NH2 Chemical Properties,Uses,Production
Uses
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].
in vivo
Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].
| Animal Model: | Male CFLP mice (25-28 g)[2] |
| Dosage: | 0.25 μg/2 μL |
| Administration: | i.c.v.; 30 min prior to the tests |
| Result: | Decreased the immobility time and increased the climbing and swimming times. |
References
[1] Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria? Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. DOI:10.1002/ar.23780
[2] Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9. DOI:10.1016/j.bbr.2014.08.007
A-18-F-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
A-18-F-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42952 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Nanjing Leon Biological Technology Co., Ltd. | 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9979 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7222 | 58 |
