Naphthofluorescein
- CAS No.
- 61419-02-1
- Chemical Name:
- Naphthofluorescein
- Synonyms
- Naphthofluorescein;Naphthafluorescein;NAPHTHOFLUORESCEIN, FOR FLUORESCENCE;NAPHTHOFLUORESCEIN FOR FLUORESCENCE 95+%;Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one,3,11-dihydroxy-
- CBNumber:
- CB1689770
- Molecular Formula:
- C28H16O5
- Molecular Weight:
- 432.42
- MDL Number:
- MFCD00329026
- MOL File:
- 61419-02-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 189 °C (dec.)(lit.) |
|---|---|
| Boiling point | 755.5±60.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: soluble |
| form | A crystalline solid |
| pka | 8.82±0.20(Predicted) |
| color | Purple to purplish red |
| BRN | 61335 |
| InChI | 1S/C28H16O5/c29-17-7-9-19-15(13-17)5-11-23-25(19)32-26-20-10-8-18(30)14-16(20)6-12-24(26)28(23)22-4-2-1-3-21(22)27(31)33-28/h1-14,29-30H |
| InChIKey | IXQIUDNVFVTQLJ-UHFFFAOYSA-N |
| SMILES | Oc1ccc2c3Oc4c(ccc5cc(O)ccc45)C6(OC(=O)c7ccccc67)c3ccc2c1 |
| EPA Substance Registry System | Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1) |
| UNSPSC Code | 12352108 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 8-10 |
| TSCA | TSCA listed |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Naphthofluorescein price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 70420 | Naphthofluorescein suitable for fluorescence | 61419-02-1 | 100mg | $95.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 70420 | Naphthofluorescein suitable for fluorescence | 61419-02-1 | 500mg | $347 | 2026-04-30 | Buy |
| Cayman Chemical | 13055 | Naphthofluorescein ≥98% | 61419-02-1 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 13055 | Naphthofluorescein ≥98% | 61419-02-1 | 10mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 13055 | Naphthofluorescein ≥98% | 61419-02-1 | 50mg | $236 | 2026-04-30 | Buy |
Naphthofluorescein Chemical Properties, Uses, Production
Uses
Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.
Uses
Naphthofluorescein is a furin inhibitor.
Definition
ChEBI: Naphthofluorescein is a member of xanthenes.
in vivo
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner[1].
| Animal Model: | Male C57BL/6J mice (8 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney, or caused cause severe adverse effects for at least 2 weeks in mice. |
| Animal Model: | Female C57BL/6J mice (E0771) and BALB/c nude mice (HT1080, MDA-MB-231, and AsPC-1) (6 weeks)[1] |
| Dosage: | 100 mg/kg |
| Administration: | i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks |
| Result: | Strikingly suppressed the tumour growth of subcutaneously injected E0771 cells and significantly attenuated tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein did not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells. |
Naphthofluorescein Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Watson Biotechnology Co.,Ltd | 027-59207879 1972026995 18140587686 | sales@3600chem.com | China | 4184 | 55 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Tianjin Being Technology Co., Ltd. | 18622939839 | tjby921@163.com | China | 635 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
View Latest Price from Naphthofluorescein manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Naphthofluorescein
61419-02-1
|
$44.00 | 99.34% | 10g | TargetMol Chemicals Inc. |
-
- Naphthofluorescein
61419-02-1
- $44.00
- 99.34%
- TargetMol Chemicals Inc.
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