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ChemicalBook >> CAS DataBase List >>(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Structure
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL structure
CAS No.
18881-17-9
Chemical Name:
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
Synonyms
Tic-ol;in-3-yL;)-methanoL;(S)-Tetrahydroisoquinolinyl-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL;(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
CBNumber:
CB1690134
Molecular Formula:
C10H13NO
Molecular Weight:
163.22
MDL Number:
MFCD01631316
MOL File:
18881-17-9.mol
MSDS File:
SDS
Last updated:2025-08-20 12:06:42
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(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Properties

Melting point 114-116 °C(lit.)
Boiling point 290.31°C (rough estimate)
Density 1.0508 (rough estimate)
refractive index -97 ° (C=0.2, MeOH)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 14.57±0.10(Predicted)
form Crystalline Powder and/or Chunks
color Off-white
optical activity [α]22/D 97°, c = 1 in methanol
CAS DataBase Reference 18881-17-9(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
Hazard Note  Irritant
HS Code  29339900

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 494186 (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 98% 18881-17-9 1g $25 2023-06-20 Buy
TCI Chemical T1755 (S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol >97.0%(HPLC)(T) 18881-17-9 1g $102 2023-01-07 Buy
AK Scientific X3151 (S)-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 18881-17-9 5g $107 2021-12-16 Buy
Ark Pharm P000190192 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 97% 18881-17-9 10g $128 2021-12-16 Buy
Frontier Specialty Chemicals JK222185 (3S)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol 98% 18881-17-9 250mg $48 2021-12-16 Buy
Product number Packaging Price Buy
494186 1g $25 Buy
T1755 1g $102 Buy
X3151 5g $107 Buy
P000190192 10g $128 Buy
JK222185 250mg $48 Buy

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

79815-19-3

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

18881-17-9

GENERAL STEPS: The experimental manipulation of this reaction was improved by referring to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether:ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline as a yellow crystalline solid (yield: 2.09 g, 98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Preparation Products And Raw materials

Raw materials

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester H-DL-TIC-OH Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Suppliers

Global( 156)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 8979 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29734 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10035 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Kindchem(Nanjing)Co.,Ltd 		+86-025-025-85281586 +8618651653755 sales@kindchem.cn China 1226 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
SIMAGCHEM CORP 		58
Kindchem(Nanjing)Co.,Ltd 		58

View Lastest Price from (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol pictures 2025-08-20 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
18881-17-9
 US $1.10-9.90 / KG 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol pictures 2020-01-19 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
18881-17-9
 US $3.00 / KG 1KG 99% 1kg,5kg,50kg Career Henan Chemical Co

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Spectrum

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)MS(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)1HNMR(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)13CNMR(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)IR1(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)IR2

18881-17-9((S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL)Related Search:

D-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (3S)-2-CARBOBENZOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID L-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid H-TIC-OH
N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid FMOC-TIC-OH BOC-7-HYDROXY-TIC-OH 1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 5,6,7,8-TETRAHYDROISOQUINOLINE
1,2,3,4-TETRAHYDROISOQUINOLINE (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Z-D-TIC-OH (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER BOC-D-TIC-OH H-D-TIC-OTBU HCL

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(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline (3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline97% (S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol (3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol (S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e. 3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (S)-3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (S)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL-METHANOL (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL (S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL (S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL (S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97% (S)-1,2,3,4-tetrahydroisoquinolne-3-methanol (S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-METHANOL 98% (3S)-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol (3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97% S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL(S)-()-1,2 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3S)- in-3-yL )-methanoL (S)-Tetrahydroisoquinolinyl-3-methanol (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL USP/EP/BP Tic-ol (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 18881-17-9 C10H13NO Chiral Building Blocks Asymmetric Synthesis Heterocyclic Building Blocks Isoquinolines chiral Chiral Building Blocks Heterocyclic Building Blocks Isoquinolines