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ChemicalBook >> CAS DataBase List >>(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Structure
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL structure
CAS No.
18881-17-9
Chemical Name:
(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
Synonyms
Tic-ol;in-3-yL;)-methanoL;(S)-Tetrahydroisoquinolinyl-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL;(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
CBNumber:
CB1690134
Molecular Formula:
C10H13NO
Molecular Weight:
163.22
MDL Number:
MFCD01631316
MOL File:
18881-17-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:41:21
Product description Number Pack Size Price
(S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 98% 494186 1g $25
(S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol >97.0%(HPLC)(T) T1755 1g $102
S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 290654 250mg $297
S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 290654 500mg $396
S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 290654 1g $513
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(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Properties

Melting point 114-116 °C(lit.)
Boiling point 290.31°C (rough estimate)
Density 1.0508 (rough estimate)
refractive index -97 ° (C=0.2, MeOH)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 14.57±0.10(Predicted)
form Crystalline Powder and/or Chunks
color Off-white
optical activity [α]22/D 97°, c = 1 in methanol
InChI 1S/C10H13NO/c12-7-10-5-8-3-1-2-4-9(8)6-11-10/h1-4,10-12H,5-7H2/t10-/m0/s1
InChIKey ZSKDXMLMMQFHGW-JTQLQIEISA-N
SMILES OC[C@@H]1Cc2ccccc2CN1
CAS DataBase Reference 18881-17-9(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
Hazard Note  Irritant
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 494186 (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 98% 18881-17-9 1g $25 2023-06-20 Buy
TCI Chemical T1755 (S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol >97.0%(HPLC)(T) 18881-17-9 1g $102 2023-01-07 Buy
Usbiological 290654 S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 18881-17-9 250mg $297 2026-06-03 Buy
Usbiological 290654 S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 18881-17-9 500mg $396 2026-06-03 Buy
Usbiological 290654 S-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol Asreported 18881-17-9 1g $513 2026-06-03 Buy
Product number Packaging Price Buy
494186 1g $25 Buy
T1755 1g $102 Buy
290654 250mg $297 Buy
290654 500mg $396 Buy
290654 1g $513 Buy

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

79815-19-3

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

18881-17-9

GENERAL STEPS: The experimental manipulation of this reaction was improved by referring to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether:ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline as a yellow crystalline solid (yield: 2.09 g, 98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Preparation Products And Raw materials

Raw materials

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester H-DL-TIC-OH Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Suppliers

Global( 157)Suppliers
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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16505 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
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Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
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Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
SIMAGCHEM CORP 		58
Kindchem(Nanjing)Co.,Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol pictures 2026-07-02 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
18881-17-9
 $1.10-9.90 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol pictures 2020-01-19 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
18881-17-9
 $3.00 1KG 99% 1kg,5kg,50kg Career Henan Chemical Co

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Spectrum

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)MS(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)1HNMR(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)13CNMR(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)IR1(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL(18881-17-9)IR2

18881-17-9((S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL)Related Search:

D-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (3S)-2-CARBOBENZOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID L-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid H-TIC-OH
N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid FMOC-TIC-OH BOC-7-HYDROXY-TIC-OH 1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 5,6,7,8-TETRAHYDROISOQUINOLINE
1,2,3,4-TETRAHYDROISOQUINOLINE (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Z-D-TIC-OH (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
(S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER BOC-D-TIC-OH H-D-TIC-OTBU HCL

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(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline (3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline97% (S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol (3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol (S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e. 3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (S)-3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE (S)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL-METHANOL (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL (S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL (S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL (S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97% (S)-1,2,3,4-tetrahydroisoquinolne-3-methanol (S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-METHANOL 98% (3S)-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol (3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97% S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL(S)-()-1,2 3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3S)- in-3-yL )-methanoL (S)-Tetrahydroisoquinolinyl-3-methanol (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL USP/EP/BP Tic-ol (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol 18881-17-9 C10H13NO Chiral Building Blocks Asymmetric Synthesis Heterocyclic Building Blocks Isoquinolines chiral Chiral Building Blocks Heterocyclic Building Blocks Isoquinolines