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ChemicalBook >> CAS DataBase List >>1,2,3,4-Tetrahydroisoquinoline-3-methanol

1,2,3,4-Tetrahydroisoquinoline-3-methanol

1,2,3,4-Tetrahydroisoquinoline-3-methanol Structure
1,2,3,4-Tetrahydroisoquinoline-3-methanol structure
CAS No.
63006-93-9
Chemical Name:
1,2,3,4-Tetrahydroisoquinoline-3-methanol
Synonyms
AKOS BB-8834;1,2,3,4-Tetrahydro-3-isoquinolinemethano;1,2,3,4-tetrahydro-3-isoquinolineMethanol;1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;3-IsoquinolineMethanol,1,2,3,4-tetrahydro-;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
CBNumber:
CB5421897
Molecular Formula:
C10H13NO
Molecular Weight:
163.22
MDL Number:
MFCD02259418
MOL File:
63006-93-9.mol
MSDS File:
SDS
Last updated:2026-05-28 04:09:27
Product description Number Pack Size Price
1,2,3,4-Tetrahydro-3-isoquinolinemethanol 98% OR451144 250mg $30
(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 301163 250.00mg $30
(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 301163 1.00g $73
(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 301163 5.00g $247
(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 98% T52934 1g $170
Request For Quotation

1,2,3,4-Tetrahydroisoquinoline-3-methanol Properties

Melting point 180-182C
Boiling point 83-85 °C(Press: 0.3 Torr)
Density 1.081±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility soluble in Dichloromethane
form Crystalline
pka 14.57±0.10(Predicted)
Appearance light yellow solid
Water Solubility Soluble in dichloromethane. Slightly soluble in water.

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
HS Code  2933499090

1,2,3,4-Tetrahydroisoquinoline-3-methanol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR451144 1,2,3,4-Tetrahydro-3-isoquinolinemethanol 98% 63006-93-9 250mg $30 2026-06-04 Buy
Matrix Scientific 301163 (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 63006-93-9 250.00mg $30 2026-05-19 Buy
Matrix Scientific 301163 (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 63006-93-9 1.00g $73 2026-05-19 Buy
Matrix Scientific 301163 (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 63006-93-9 5.00g $247 2026-05-19 Buy
Synthonix T52934 (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 98% 63006-93-9 1g $170 2026-05-06 Buy
Product number Packaging Price Buy
OR451144 250mg $30 Buy
301163 250.00mg $30 Buy
301163 1.00g $73 Buy
301163 5.00g $247 Buy
T52934 1g $170 Buy

1,2,3,4-Tetrahydroisoquinoline-3-methanol Chemical Properties,Uses,Production

Chemical Properties

Light Orange Solid

Uses

rac 1,2,3,4-Tetrahydroisoquinoline-3-methanol (cas# 63006-93-9) is a compound useful in organic synthesis.

Synthesis

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

79815-19-3

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

18881-17-9

GENERAL STEPS: The synthesis was modified with reference to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the reaction progress was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether: ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (4) as a yellow crystalline solid in a yield of 2.09 g (98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in the literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

1,2,3,4-Tetrahydroisoquinoline-3-methanol Preparation Products And Raw materials

Raw materials

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester H-DL-TIC-OH Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

1,2,3,4-Tetrahydroisoquinoline-3-methanol Suppliers

Global( 83)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21135 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
PT CHEM GROUP LIMITED 		+86-85511178; +86-85511178 peter68@ptchemgroup.com China 35405 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49859 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Young Lively PharminBlock Co.,Ltd 		18600731423 jason_gao@yl-pharminblock.com China 1943 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Young Lively PharminBlock Co.,Ltd 		58

View Lastest Price from 1,2,3,4-Tetrahydroisoquinoline-3-methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydroisoquinoline-3-methanol pictures 2020-01-03 1,2,3,4-Tetrahydroisoquinoline-3-methanol
63006-93-9
 $1.00 1KG 99% 200kg Career Henan Chemical Co

1,2,3,4-Tetrahydroisoquinoline-3-methanol Spectrum

1,2,3,4-Tetrahydroisoquinoline-3-methanol(63006-93-9)1HNMR

63006-93-9(1,2,3,4-Tetrahydroisoquinoline-3-methanol)Related Search:

Isoquinoline Methyl tetrahydrophthalic anhydride Tetramethylammonium hydroxide pentahydrate 1,2,3,4-Tetrahydroquinoline Methanol
Tetrahydrothiophene cis-1,2,3,6-Tetrahydrophthalic anhydride 1,2,3,4-TETRAHYDROISOQUINOLINE Tetramethylammonium hydroxide 1,1,3,3-Tetramethyldisiloxane
Tetrakis(hydroxymethyl)phosphonium sulfate Tetrahydrofuran Tetrabutylammonium hydroxide DELTA9-TETRAHYDROCANNABINOL 5,6,7,8-TETRAHYDROISOQUINOLINE
(S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 1,2,3,4-Tetrahydroisoquinoline-3-methanol

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1,2,3,4-Tetrahydro-3-isoquinolinemethano 3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AKOS BB-8834 1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 1,2,3,4-tetrahydro-3-isoquinolineMethanol 3-IsoquinolineMethanol,1,2,3,4-tetrahydro- 63006-93-9 Aromatics pharmacetical