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H-DL-Tic-OH

H-DL-Tic-OH Structure
H-DL-Tic-OH structure
CAS No.
67123-97-1
Chemical Name:
H-DL-Tic-OH
Synonyms
1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;DL-Tic-OH;NSC 14794;H-DL-Tic-OH;AKOS BB-6895;3-CARBOXY-1,2,3,4-TETRAHYDROISOQUINOLINE;1,2,3,4-Tetrahydroisoquinoline-3Carboxylic;DL-3-Carboxy-1,2,3,4-tetrahydroisoquinoline;rac 3-Carboxy-1,2,3,4-tetrahydroisoquinoline;1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC ACID
CBNumber:
CB1349115
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
MDL Number:
MFCD00191496
MOL File:
67123-97-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:49:12
Request For Quotation

H-DL-Tic-OH Properties

Melting point 358°C
Boiling point 372.0±42.0 °C(Predicted)
Density 1.225±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Sodium Hydroxide, Water
pka 2.21±0.20(Predicted)
form Solid
color White
InChI 1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)
InChIKey BWKMGYQJPOAASG-UHFFFAOYSA-N
SMILES OC(=O)C1Cc2ccccc2CN1
CAS DataBase Reference 67123-97-1
FDA UNII C0KDL86B2L
UNSPSC Code 12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  WGK 3
HS Code  2933499090
Storage Class 11 - Combustible Solids

H-DL-Tic-OH price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T4195 H-DL-Tic-OH 67123-97-1 5G $70 2026-04-30 Buy
TRC TRC-T293750-500MG rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 67123-97-1 500mg $129 2026-06-03 Buy
TRC TRC-T293750-2G rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 67123-97-1 2g $281 2026-06-03 Buy
TRC TRC-T293750-1G rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid 67123-97-1 1g $148 2026-06-03 Buy
Apolloscientific OR28891 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 98% 67123-97-1 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
T4195 5G $70 Buy
TRC-T293750-500MG 500mg $129 Buy
TRC-T293750-2G 2g $281 Buy
TRC-T293750-1G 1g $148 Buy
OR28891 5g $21 Buy

H-DL-Tic-OH Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (cas# 67123-97-1) is a compound useful in organic synthesis.

Synthesis

Formaldehyde

50-00-0

DL-Phenylalanine

150-30-1

H-DL-TIC-OH

67123-97-1

D,L-phenylalanine (50 g, 3.03 mol) was used as raw material to prepare its suspension. Concentrated hydrochloric acid (325 mL) and 37% formaldehyde solution (110 mL) were added to the suspension under vigorous stirring and heated to a mild reflux condition and maintained for 30 min. Subsequently, additional formaldehyde (50 mL) and concentrated hydrochloric acid (110 mL) were added and the reaction continued to heat for 4 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The solid was washed with methanol (30 mL) and dried to afford the target compound 3-carboxy-1,2,3,4-tetrahydroisoquinoline in a yield of 64.09 g (98.9% yield) with a melting point of 295-298 °C (decomposition temperature >326 °C) (Literature reference: Julian PL, J. Chem. Soc. 1948, 70, 180-183) as an enantiomeric mixtures. Its NMR hydrogen spectrum (DMSO-d6) data are as follows: δ 3.10-3.18 (1H, m, CH), 3.28-3.34 (1H, m, CH), 4.27 (2H, s, CH2), 4.39 (1H, m, CH), 7.25-7.27 (4H, m, 4*ArH), 9.89 (1H, brs, exchangeable, NH) , 10.06 (1H, brs, exchangeable, OH). Mass spectral data: m/z 177.0 (M+H)+.

References

[1] Patent: US2009/117125, 2009, A1. Location in patent: Page/Page column 15
[2] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 12, p. 3729 - 3731
[3] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 180,182
[5] Journal of Organic Chemistry, 1951, vol. 16, p. 430

H-DL-Tic-OH Preparation Products And Raw materials

Raw materials

Formaldehyde DL-Phenylalanine Water Hydrochloric acid

Preparation Products

3-Isoquinolinecarbonitrile Methyl 3-isoquinolinecarboxylate

H-DL-Tic-OH Suppliers

Global( 144)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Record Tech (Shanghai) Co., LTD 13761627472 183009664@qq.com China 661 62
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Baiyin Chengze Chemical Technology Co., Ltd. +86 943-8535351 13389336721 sales@chengzechem.com China 300 58
Shanghai Litong Chemical Technology Co.,Ltd. 13598610367 0373-7129549 2468833170@qq.com China 932 58
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9849 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Beijing Ouhe Technology Co., Ltd 60
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Record Tech (Shanghai) Co., LTD 62
Hangzhou Sage Chemical Co., Ltd. 58
Baiyin Chengze Chemical Technology Co., Ltd. 58
Shanghai Litong Chemical Technology Co.,Ltd. 58
Amatek Scientific Co. Ltd. 55

View Lastest Price from H-DL-Tic-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-DL-TIC-OH pictures 2021-07-13 H-DL-TIC-OH
67123-97-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
H-DL-TIC-OH pictures 2021-07-10 H-DL-TIC-OH
67123-97-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
H-DL-TIC-OH pictures 2019-12-24 H-DL-TIC-OH
67123-97-1
 $1.00 100g 98%min Career Henan Chemical Co
  • H-DL-TIC-OH pictures
  • H-DL-TIC-OH
    67123-97-1
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • H-DL-TIC-OH pictures
  • H-DL-TIC-OH
    67123-97-1
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • H-DL-TIC-OH pictures
  • H-DL-TIC-OH
    67123-97-1
  • $1.00
  • 98%min
  • Career Henan Chemical Co

H-DL-Tic-OH Spectrum

H-DL-TIC-OH(67123-97-1)1HNMR

67123-97-1(H-DL-Tic-OH)Related Search:

1,2,3,4-Tetrahydroisoquinoline H-DL-Tic-OH Isoquinoline-1-carboxylic acid Quinapril (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrobromide
Benzyl (S)-(-)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate p-toluenesulfonic acid salt (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride Quinapril benzyl ester maleate Quinapril hydrochloride (S)-6,7-Dimethoxy-1,2,3,3-tetrahydro-2-isoquinolinecarboxylic acid hydrochloride
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

1of3

DL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID 1,2,3,4-Tetrahydroisoquinoline-3Carboxylic rac 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid rac 3-Carboxy-1,2,3,4-tetrahydroisoquinoline (RS)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 98% 3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro- DL-3-Carboxy-1,2,3,4-tetrahydroisoquinoline NSC 14794 DL-Tic-OH 1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC ACID rac-(3R*)-1,2,3,4-Tetrahydro-3β*-isoquinolinecarboxylic acid rac-(3R*)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid rac-(3S*)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid rac-(R*)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid,98% 3-CARBOXY-1,2,3,4-TETRAHYDROISOQUINOLINE AKOS BB-6895 (±)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID H-DL-Tic-OH 67123-97-1 Isoquinolines Heterocyclic Building Blocks Building Blocks Aromatics Compounds Aromatics Quinoline&Isoquinoline