3-Morpholin-4-ylbenzonitrile
- CAS No.
- 204078-31-9
- Chemical Name:
- 3-Morpholin-4-ylbenzonitrile
- Synonyms
- 3-morpholinobenzonitrile;4-(3-Cyanophenyl)morpholine;3-Morpholin-4-ylbenzonitrile;3-(4-Morpholinyl)Benzonitrile;Benzonitrile, 3-(4-morpholinyl)-;3-(Morpholin-4-yl)benzonitrile97%
- CBNumber:
- CB1709896
- Molecular Formula:
- C11H12N2O
- Molecular Weight:
- 188.23
- MDL Number:
- MFCD07368523
- MOL File:
- 204078-31-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
3-Morpholin-4-ylbenzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS49391 | 3-Morpholinobenzonitrile 97% | 204078-31-9 | 1g | $42 | 2026-06-04 | Buy |
| Activate Scientific | AS49391 | 3-Morpholinobenzonitrile 97% | 204078-31-9 | 5g | $137 | 2026-06-04 | Buy |
| Activate Scientific | AS49391 | 3-Morpholinobenzonitrile 97% | 204078-31-9 | 25g | $430 | 2026-06-04 | Buy |
| Apolloscientific | OR4431 | 3-(Morpholin-4-yl)benzonitrile 97% | 204078-31-9 | 1g | $22 | 2026-06-04 | Buy |
| Matrix Scientific | 084770 | 3-Morpholin-4-ylbenzonitrile | 204078-31-9 | 1.00g | $157 | 2026-05-18 | Buy |
3-Morpholin-4-ylbenzonitrile Chemical Properties, Uses, Production
Synthesis
110-91-8
873-62-1
204078-31-9
The general procedure for the synthesis of 3-morpholino benzonitrile from 3-hydroxybenzonitrile and morpholine is as follows: 1. 3-hydroxybenzonitrile (1.77 g, 14.9 mmol) and triethylamine (6.30 ml, 45.2 mmol) were dissolved in dichloromethane (75 ml) under argon protection, cooled to -10 °C and stirred. 2. A solution of trifluoroacetic anhydride (3.79 ml, 22.5 mmol) dissolved in dichloromethane (15 ml) was added slowly and dropwise, and the reaction mixture was continued to be stirred at -10 °C for 1.5 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the concentrated residue, aqueous sodium bicarbonate solution was added and extracted with dichloromethane. 4. The organic layer was washed with saturated brine and dried with anhydrous sodium sulfate. The filtrate was concentrated by filtration to remove the desiccant. 5. The concentrated residue was purified using silica gel column chromatography (eluent: chloroform/methanol=100:1) to obtain an oily intermediate. 6. The above oily intermediate was dissolved in acetonitrile (40 ml), morpholine (33.0 ml, 378 mmol) was added and stirred at reflux for 3 days. 7. After completion of the reaction, the solvent and unreacted morpholine were removed by distillation under reduced pressure. Water was added to the concentrated residue and extracted with chloroform. 8. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated. 9. Finally, the concentrated residue was purified using silica gel column chromatography (eluent: chloroform/hexane=1:2) to afford the target product 3-morpholino benzonitrile as an oil (0.74 g, 26% yield). The product was characterized by 1H-NMR (CDCl3): δ (ppm) 3.15-3.19 (4H, m), 3.83-3.88 (4H, m), 7.09-7.18 (3H, m), 7.34 (1H, dd, J=7.6Hz, 7.6Hz).
References
[1] Patent: US2002/193389, 2002, A1
[2] Patent: US6127541, 2000, A
3-Morpholin-4-ylbenzonitrile Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1997 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Chengdu J&B Technology Co., Ltd. | 028-61186694 15608078506 | 609128801@qq.com | China | 853 | 55 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2985 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Zhengzhou Ruke Biological Co., Ltd. | 15981811963 | 1410472904@qq.com | China | 5824 | 58 |
