3-MORPHOLIN-4-YLBENZONITRILE
- CAS No.
- 204078-31-9
- Chemical Name:
- 3-MORPHOLIN-4-YLBENZONITRILE
- Synonyms
- 3-morpholinobenzonitrile;4-(3-Cyanophenyl)morpholine;3-MORPHOLIN-4-YLBENZONITRILE;3-(4-Morpholinyl)Benzonitrile;Benzonitrile, 3-(4-morpholinyl)-;3-(Morpholin-4-yl)benzonitrile97%
- CBNumber:
- CB1709896
- Molecular Formula:
- C11H12N2O
- Molecular Weight:
- 188.23
- MDL Number:
- MFCD07368523
- MOL File:
- 204078-31-9.mol
| Product description | Number | Pack Size | Price |
| 3-Morpholin-4-ylbenzonitrile | M725295 | 25mg | $45 |
| 3-Morpholinobenzonitrile | CS-0060408 | 1g | $53 |
| 3-(Morpholin-4-yl)benzonitrile 97% | OR4431 | 1g | $37 |
| 3-(Morpholin-4-yl)benzonitrile 97% | 4H37-1-4N | 1g | $40 |
| 3-Morpholin-4-ylbenzonitrile 97% | 084770 | 1g | $157 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
3-MORPHOLIN-4-YLBENZONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M725295 | 3-Morpholin-4-ylbenzonitrile | 204078-31-9 | 25mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-0060408 | 3-Morpholinobenzonitrile | 204078-31-9 | 1g | $53 | 2021-12-16 | Buy |
| Apolloscientific | OR4431 | 3-(Morpholin-4-yl)benzonitrile 97% | 204078-31-9 | 1g | $37 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H37-1-4N | 3-(Morpholin-4-yl)benzonitrile 97% | 204078-31-9 | 1g | $40 | 2021-12-16 | Buy |
| Matrix Scientific | 084770 | 3-Morpholin-4-ylbenzonitrile 97% | 204078-31-9 | 1g | $157 | 2021-12-16 | Buy |
3-MORPHOLIN-4-YLBENZONITRILE Chemical Properties,Uses,Production
Synthesis
110-91-8
873-62-1
204078-31-9
The general procedure for the synthesis of 3-morpholino benzonitrile from 3-hydroxybenzonitrile and morpholine is as follows: 1. 3-hydroxybenzonitrile (1.77 g, 14.9 mmol) and triethylamine (6.30 ml, 45.2 mmol) were dissolved in dichloromethane (75 ml) under argon protection, cooled to -10 °C and stirred. 2. A solution of trifluoroacetic anhydride (3.79 ml, 22.5 mmol) dissolved in dichloromethane (15 ml) was added slowly and dropwise, and the reaction mixture was continued to be stirred at -10 °C for 1.5 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the concentrated residue, aqueous sodium bicarbonate solution was added and extracted with dichloromethane. 4. The organic layer was washed with saturated brine and dried with anhydrous sodium sulfate. The filtrate was concentrated by filtration to remove the desiccant. 5. The concentrated residue was purified using silica gel column chromatography (eluent: chloroform/methanol=100:1) to obtain an oily intermediate. 6. The above oily intermediate was dissolved in acetonitrile (40 ml), morpholine (33.0 ml, 378 mmol) was added and stirred at reflux for 3 days. 7. After completion of the reaction, the solvent and unreacted morpholine were removed by distillation under reduced pressure. Water was added to the concentrated residue and extracted with chloroform. 8. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated. 9. Finally, the concentrated residue was purified using silica gel column chromatography (eluent: chloroform/hexane=1:2) to afford the target product 3-morpholino benzonitrile as an oil (0.74 g, 26% yield). The product was characterized by 1H-NMR (CDCl3): δ (ppm) 3.15-3.19 (4H, m), 3.83-3.88 (4H, m), 7.09-7.18 (3H, m), 7.34 (1H, dd, J=7.6Hz, 7.6Hz).
References
[1] Patent: US2002/193389, 2002, A1
[2] Patent: US6127541, 2000, A
3-MORPHOLIN-4-YLBENZONITRILE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Henan Rane Chemical Co., Ltd. | +8618738066252 | info@ranechem.com | China | 2999 | 58 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 2000 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6886 | 55 |
