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Di-tert-butyl iminodicarboxylate

Di-tert-butyl iminodicarboxylate Structure
Di-tert-butyl iminodicarboxylate structure
CAS No.
51779-32-9
Chemical Name:
Di-tert-butyl iminodicarboxylate
Synonyms
di-tert-butyl iminodicarbonate;(BOC)2NH;DI-T-BUTYL IMINODICARBOXYLATE;IMINODICARBOXYLIC ACID DI-TERT-BUTYL ESTER;DI-TERT-BUTYL IMIDODICARBONATE;Bis(tert-butoxycarbonyl)amine;DBNH;Di-Boc Amine;(BOC)2NH FLUKA;IminodicarboxyL
CBNumber:
CB1720945
Molecular Formula:
C10H19NO4
Molecular Weight:
217.26
MDL Number:
MFCD00043309
MOL File:
51779-32-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:44:06
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Di-tert-butyl iminodicarboxylate Properties

Melting point 114-117 °C(lit.)
Boiling point 273.8±9.0 °C(Predicted)
Density 1.037±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol
pka 8.25±0.46(Predicted)
form Crystalline Powder
color White to beige
Water Solubility Insoluble in water.
Sensitive Air & Light Sensitive
BRN 1911172
InChI InChI=1S/C10H19NO4/c1-9(2,3)14-7(12)11-8(13)15-10(4,5)6/h1-6H3,(H,11,12,13)
InChIKey XCAQIUOFDMREBA-UHFFFAOYSA-N
SMILES C(C)(C)(C)OC(=O)NC(=O)OC(C)(C)C
CAS DataBase Reference 51779-32-9(CAS DataBase Reference)
FDA UNII 85M4Q7458H
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
Hazard Note  Irritant
HS Code  29241990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Di-tert-butyl iminodicarboxylate price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 375276 Di-tert-butyl Iminodicarboxylate ≥96% 51779-32-9 5g $139 2026-04-30 Buy
Sigma-Aldrich 375276 Di-tert-butyl Iminodicarboxylate ≥96% 51779-32-9 25g $228 2026-04-30 Buy
TCI Chemical I0497 Di-tert-butyl Iminodicarboxylate >95.0%(GC) 51779-32-9 5g $27 2026-04-30 Buy
TCI Chemical I0497 Di-tert-butyl Iminodicarboxylate >95.0%(GC) 51779-32-9 25g $86 2026-04-30 Buy
Usbiological 446513 Di-tert-butyl Iminodicarboxylate 51779-32-9 1g $312 2026-06-03 Buy
Product number Packaging Price Buy
375276 5g $139 Buy
375276 25g $228 Buy
I0497 5g $27 Buy
I0497 25g $86 Buy
446513 1g $312 Buy

Di-tert-butyl iminodicarboxylate Chemical Properties,Uses,Production

Synthesis

Synthesis of 51779-32-9

A solution of DMAP (0.61 g, 5.0 mmol) in MeCN (15 ml) was slowly added to a solution of formamide (2.5 g, 56 mmol) and Boc2O (24 g, 110 mol) in MeCN (15 ml). After stirring at room temperature for 4 h, the yellow solution was cooled to 0 °C, and N,N-diethylethylenediamine (6.97 g, 60 mmol) was slowly added at 0 °C. The resulting mixture was stirred at room temperature for 12 h and filtered through a silica mat; the resulting mixture was then filtered at room temperature. The solvent was then evaporated under reduced pressure. The crude product was purified by silica gel chromatography, eluted with EtOAc/hexane (1:5) to give the title product as a white solid (10.99 g, 92%).

Uses

Di-tert-butyl-iminodicarboxylate is an organic compound that can be described with the formula [(CH3)3COC(O)]2NH. It is a white solid that is soluble in organic solvents. The compound is used as a reagent for the preparation of primary amines from alkyl halides. It was popularized as an alternative to the Gabriel synthesis for the same conversion. Amines can also be prepared from alcohols by dehydration using the Mitsunobu reaction. In the usual implementation the reagent is deprotonated to give the potassium salt, which is N-alkylated. The Boc protecting groups are subsequently removed under acidic conditions.

Chemical Properties

White to beige crystalline powder

Uses

Di-tert-butyl iminodicarboxylate is a protected amine group that is used to prepare conformationally constrained spirocycles as CCR1 antagonists.

Di-tert-butyl iminodicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

N-(tert-Butoxycarbonyl)-2-aminoacetonitrile BIS(1,1-DIMETHYLETHYL)(3-BROMOPROPYL) IMIDODICARBONATE

Di-tert-butyl iminodicarboxylate Suppliers

Global( 358)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
Suzhou lipin Chemical Co., Ltd 0512-67509664 19888480046 3516936381@qq.com China 111 58
Anhui Dexinjia Biopharm Co., Ltd 0531-82375893 15553111391 phoebe@jndxj.com China 285 58
Shanghai Chiral Chemicals Inc. 021-37285021 13472570865 tym7xi@aliyun.com China 299 64
Xuzhou Kangcheng Pharmaceutical Technology Co., Ltd. 021-58950017 18018668861 sales5@langchem.com China 20 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 9995 58
Jinan Huadian New Materials Co., Ltd 18654517877 18654517877 372725134@qq.COM China 20 58
Shanghai Pulikang Chemical Technology Co., Ltd 13105330140 13105330140 icyan@126.com China 266 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Suzhou Highfine Biotech Co., Ltd 75
Shanghai Hobor Chemical Co., Ltd 60
Suzhou lipin Chemical Co., Ltd 58
Anhui Dexinjia Biopharm Co., Ltd 58
Shanghai Chiral Chemicals Inc. 64
Xuzhou Kangcheng Pharmaceutical Technology Co., Ltd. 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
Jinan Huadian New Materials Co., Ltd 58
Shanghai Pulikang Chemical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76

Related articles

View Lastest Price from Di-tert-butyl iminodicarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Di-tert-butyl iminodicarboxylate pictures 2026-08-18 Di-tert-butyl iminodicarboxylate
51779-32-9
 1KG 98% 1000 KG Shaanxi Dideu New Materials Co. Ltd
Di-tert-butyl iminodicarboxylate pictures 2026-07-30 Di-tert-butyl iminodicarboxylate
51779-32-9
 $15.00-50.00 1kg NLT98% 5 ton per month Anhui Dexinjia Biopharm Co., Ltd
Di-tert-butyl iminodicarboxylate pictures 2025-06-27 Di-tert-butyl iminodicarboxylate
51779-32-9
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

Di-tert-butyl iminodicarboxylate Spectrum

Di-tert-butyl iminodicarboxylate(51779-32-9)1HNMRDi-tert-butyl iminodicarboxylate(51779-32-9)IR

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N-BOC-TERT-BUTYLCARBAMATE TERT-BUTYL IMINODICARBOXYLATE Bis(tert-butoxycarbonyl)ammonia~N-Boc-tert-butylcarbamate DI-TERT-BUTYL IMINODICARBOXYLATE, 96+% Di-tert-butyl iminodicarboxylate,Ticagrelor intermediate (BOC)2NH FLUKA Bis(tert-butoxycarbonyl)amine IMINODICARBOXYLIC ACID DI-TERT-BUTYL ESTER LABOTEST-BB LT00233154 DI-TERT-BUTYL IMINODICARBOXYLATE DI-TERT-BUTYL IMIDODICARBONATE Di-τ-butyl iminodicarboxylate≥ 98%(HPLC) Di-tert-butyl iminodicarboxylate 51779-32-9 Di-tert-butyl iminodicarboxylate Factory COA TDS MSDS tert-butyl N-tert-butoxy carbonyl carbamate N-Boc-tert-butylcarbamate, tert-Butyl iminodicarboxylate Di-t-butyl iminodicarbonate Di-tert-B-butyl iminodicarboxylate, 97% Bis(tert-butyloxycarbonyl)amine Iminobis(formic acid tert-butyl) ester N-(tert-Butoxycarbonyl)carbamic acid tert-butyl ester N-[tert-Butyloxycarbonyl]carbamic acid tert-butyl ester Di-tert-butyl iminodicarboxylate,97% di-tert-butyl iminocarboxylate[HN(boc)2] Di-tert-butyl iminod Imidodicarbonic acid, C,C'-bis(1,1-dimethylethyl) ester Di-(tert-butyl) imidodicarbonate 97% Di-tert-butyl iminodicarboxylate, N-BOC-tert-Butylcarbamate tert-Butyl Iminodicarboxylate Iminodicarboxylic Acid Di-tert-butyl Ester Di-tert-butyl iMinodicarboxylate (BOC)2NH Di-tert-butyl iMinodicarboxylate IMidodicarbonic acid,1,3-bis(1,1-diMethylethyl) ester Di-tert-butyl aMMoniuM oxalate Imidodicarbonic acid, bis(1,1-dimethylethyl) ester bis(tert-butoxycarbonyl)ammonia Di-tert-butyl iminodicarboxylate 97% Di-tert-butyl-iminodicarboxylate, 98%, for synthesis Di-tert-butylIminodicarboxylate> IminodicarboxyL DBNH tert-butyl N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate Di-Tert-Butyl Iminodicarboxylate CAS No.?51779-32-9 1,3-Bis(1,1-dimethylethyl) imidodicarbonate Di-Boc Amine 1,3-Bis(tert-butyl) imidodicarbonate (BOC)2NH DI-T-BUTYL IMINODICARBOXYLATE di-tert-butyl iminodicarbonate 51779-32-9 51999-32-9 CH33COCO2NH Specialty Synthesis Unnatural Amino Acid Derivatives Organic Building Blocks Nitrogen Compounds Protected Amines Peptide Synthesis Amination