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2-Chloro-4-methylsulphonylbenzoic acid

2-Chloro-4-methylsulphonylbenzoic acid Structure
2-Chloro-4-methylsulphonylbenzoic acid structure
CAS No.
53250-83-2
Chemical Name:
2-Chloro-4-methylsulphonylbenzoic acid
Synonyms
2-Chloro-4-Met;RARECHEM AL BE 1445;TIMTEC-BB SBB003254;2-Chloro-4-methylsul;Bupropion Impurity 46;2-chloro-4-sulfonyl acid;2-Chloro-4-mesylbenzoic acid;2-chloro-4-methylsulfonylbenzoate;2-Chloro-4-methylsulfonylbenzoic a;2-Chlor-4-(methylsulfonyl)benzoesure
CBNumber:
CB1724059
Molecular Formula:
C8H7ClO4S
Molecular Weight:
234.66
MDL Number:
MFCD00216496
MOL File:
53250-83-2.mol
MSDS File:
SDS
Last updated:2026-08-28 09:47:29
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2-Chloro-4-methylsulphonylbenzoic acid Properties

Melting point 192-193 °C
Boiling point 454.8±45.0 °C(Predicted)
Density 1.4452 (estimate)
storage temp. Sealed in dry,Room Temperature
pka 2.09±0.25(Predicted)
form Powder
color White to light yellow or light pink
InChI InChI=1S/C8H7ClO4S/c1-14(12,13)5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
InChIKey CTTWSFIIFMWHLQ-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(S(C)(=O)=O)C=C1Cl
CAS DataBase Reference 53250-83-2(CAS DataBase Reference)
EWG's Food Scores 1
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280i-P305+P351+P338-P280-P305+P351+P338+P310
Hazard Codes  Xi
Risk Statements  41-36/37/38
Safety Statements  36/37/39-26-22-39
WGK Germany  WGK 3
Hazard Note  Irritant
HS Code  29309090
Storage Class 13 - Non Combustible Solids
Hazard Classifications Eye Dam. 1
REACH Registrations Inactive
NFPA 704
1
2 0

2-Chloro-4-methylsulphonylbenzoic acid price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2726 2-Chloro-4-(methylsulfonyl)benzoic Acid >98.0%(GC)(T) 53250-83-2 5g $28 2026-04-30 Buy
TCI Chemical C2726 2-Chloro-4-(methylsulfonyl)benzoic Acid >98.0%(GC)(T) 53250-83-2 25g $77 2026-04-30 Buy
Usbiological 269284 2-Chloro-4-methylsulfonylbenzoic acid Asreported 53250-83-2 100g $398 2026-06-03 Buy
Biosynth FC36603 2-Chloro-4-methylsulfonylbenzoic acid 53250-83-2 0.25kg $150 2026-06-04 Buy
Biosynth FC36603 2-Chloro-4-methylsulfonylbenzoic acid 53250-83-2 0.1kg $150 2026-06-04 Buy
Product number Packaging Price Buy
C2726 5g $28 Buy
C2726 25g $77 Buy
269284 100g $398 Buy
FC36603 0.25kg $150 Buy
FC36603 0.1kg $150 Buy

2-Chloro-4-methylsulphonylbenzoic acid Chemical Properties, Uses, Production

Chemical Properties

WHITE TO LIGHT YELLOW OR LIGHT PINK POWDER

Uses

2-Chloro-4-methylsulphonylbenzoic acid is an intermediate between the herbicides sulfadiazine and nifedipine.

Synthesis

2-CHLORO-4-(METHYLSULFONYL)BENZALDEHYDE

101349-95-5

2-Chloro-4-methylsulphonylbenzoic acid

53250-83-2

General procedure for the synthesis of 2-chloro-4-methylsulfonylbenzoic acid from compound (CAS:101349-95-5): acetonitrile (4 mL) and compound 5 (100 mg, 0.46 mmol) were added to a 10 mL three-necked flask and stirred until complete dissolution. After cooling the reaction mixture to 0 °C, an aqueous solution of NaClO2 (124 mg, 1.38 mmol) was slowly added. Subsequently, 1 mL of HCl (117 μL) was added and stirred for 0.5 h at 0 °C. The reaction system was warmed up to 80 °C and stirring was continued for 0.5 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was dried with acetonitrile, the pH was adjusted to 2 with 1N HCl aqueous solution and then the organic phase was separated by extraction with ethyl acetate and water. The organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the organic solvent to give the crude product. The crude product was purified by column chromatography using petroleum ether and ethyl acetate (1:1, v/v) as eluents, and concentrated under reduced pressure (5 torr) to give compound 32 as a white solid (50 mg, 46.6% yield).

References

[1] Patent: CN107556289, 2018, A. Location in patent: Paragraph 0142; 0144; 0145; 0146

2-Chloro-4-methylsulphonylbenzoic acid Preparation Products And Raw materials

Raw materials

Sodium sulfate 2-Chloro-4-(methylsulfonyl)benzaldehyde 2-Chloro-1-methyl-(4-methylsulfonyl) benzene Acetonitrile Hydrochloric acid
Sodium chlorite

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Preparation Products

(2-Chloro-4-methanesulfonyl-phenyl)-methanol Benzoyl chloride, 2-chloro-4-(methylsulfonyl)-

2-Chloro-4-methylsulphonylbenzoic acid Suppliers

Global Suppliers ( 309)
Supplier Tel Email Country ProdList Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 021-69106960 13701823997 13701823733@163.com China 4634 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 2-Chloro-4-methylsulphonylbenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-methylsulphonylbenzoic acid pictures 2026-09-02 2-Chloro-4-methylsulphonylbenzoic acid
53250-83-2
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Chloro-4-methylsulphonylbenzoic acid pictures 2026-07-30 2-Chloro-4-methylsulphonylbenzoic acid
53250-83-2
 1kg 98 1000kgs Shaanxi Dideu New Materials Co. Ltd
2-Chloro-4-methylsulphonylbenzoic acid pictures 2025-06-27 2-Chloro-4-methylsulphonylbenzoic acid
53250-83-2
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

2-Chloro-4-methylsulphonylbenzoic acid Spectrum

2-Chloro-4-methylsulphonylbenzoic acid(53250-83-2)1HNMR

53250-83-2 (2-Chloro-4-methylsulphonylbenzoic acid) Related Search:

Dimethyl sulfone 4-(Chloromethyl)benzoic acid Sulfosulfuron 4-Methylsulphonylbenzoic acid Chlorosulfonyl isocyanate
Thiamphenicol Phenylmethylsulfonyl fluoride 2-Nitro-4-methylsulfonyltoluene Florfenicol 3-Chloroperoxybenzoic acid
Difluorochloromethane Benzoic acid RARECHEM AL BF 1445 2,3-Dichloro-4-(ethylsulfonyl)benzenecarboxylic acid Methyl 2-chloro-3-methyl-4-methylsulfonylbenzoate
2-Chloro-4-methylsulphonylbenzoic acid AQUANTRAAL Benzoicacid

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TIMTEC-BB SBB003254 RARECHEM AL BE 1445 2-CHLORO-4-METHYLSULPHONYLBENZOIC ACID 2-CHLORO-4-(METHYLSULFONYL)BENZOIC ACID 2-CHLORO-4-(METHANESULFONYL)BENZOIC ACID 2-Chlor-4-(methylsulfonyl)benzoesure 2-CHLORO-4-(METHYLSULFONYL)BENZOIC ACID (DRY BASIS) 2-Chloro-4-(methylsulfonyl)benzoic acid, 95% (dry basis) 2-Chloro-4-mesylbenzoic acid 4-[Methylsulfonyl]-2-chlorobenzoic acid 2-Chloro-4-methylsulphonylbenzoic acid,95% 2-Chloro-4-methylsul 4-Carboxy-3-chlorophenyl methyl sulphone 2 - chloro - 4 - thiaMphenicol base benzoic acid 2-chloro-4-sulfonyl acid 2-Chloro-4-Met Vismodegib int-2 2-chloro-4-(methylsulfonyl)benzoic acid 2-chloro-4-methylsulfonylbenzoate 2-Chloro-4-methanesulfonyl-benzoic ac 2-Chloro-4-(methylsulfonyl)benzoic Acid > 2-Chloro-4-methylsulfonylbenzoic a Benzoic acid, 2-chloro-4-(methylsulfonyl)- 2-Chloro-4-(Methylsulfonyl)BenzoicAci Factory Direct Sales 2-Chloro-4-Methylsulphonylbenzoic Acid CAS 53250-83-2 2-Chloro-4-(methylsulfonyl)benzoic acid, 96%, Bupropion Impurity 46 C11447000 2-Chloro-4-methylsulfonylbenzoiCac 53250-83-2 53280-83-2 13324-35-7 C8H7CIO4S C8H7O4ClS ARYL ACID Carboxylic Acids Phenyls & Phenyl-Het Carboxylic Acids Phenyls & Phenyl-Het bc0001