4-(Chloromethyl)benzoic acid
- CAS No.
- 1642-81-5
- Chemical Name:
- 4-(Chloromethyl)benzoic acid
- Synonyms
- P-(CHLOROMETHYL)BENZOIC ACID;AKOS BBS-00004025;RARECHEM AL BO 0358;-Chloro-p-toluicacid;à-chloro-p-toluic acid;4-Chloro-p-toluic acid;Tranexamic Impurity 16;P-(Chloromethyl)benzoic;p-Carboxbenzyl chloride;α-Chloro-p-toluylic acid
- CBNumber:
- CB5739282
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00002568
- MOL File:
- 1642-81-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 201-202 °C(lit.) |
|---|---|
| Boiling point | 201-203 °C |
| Density | 1.315±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.11±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to slightly yellow |
| Sensitive | Moisture Sensitive |
| BRN | 1907970 |
| InChI | InChI=1S/C8H7ClO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11) |
| InChIKey | OITNBJHJJGMFBN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(CCl)C=C1 |
| CAS DataBase Reference | 1642-81-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Chloromethyl)benzoic acid(1642-81-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H334 | |||||||||
| Precautionary statements | P260-P280-P284-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-42/43-36 | |||||||||
| Safety Statements | 26-36/37/39-45-22-27-37/37/39 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Resp. Sens. 1 Skin Corr. 1B |
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| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-(Chloromethyl)benzoic acid price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 270792 | 4-(Chloromethyl)benzoic acid 95% | 1642-81-5 | 10g | $69.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 270792 | 4-(Chloromethyl)benzoic acid 95% | 1642-81-5 | 50g | $314 | 2026-04-30 | Buy |
| TCI Chemical | C1212 | 4-(Chloromethyl)benzoic Acid >98.0%(GC)(T) | 1642-81-5 | 25g | $60 | 2026-04-30 | Buy |
| Usbiological | 267341 | p-Chloromethyl Benzoic acid Asreported | 1642-81-5 | 25g | $319 | 2026-06-03 | Buy |
| Usbiological | 267341 | p-Chloromethyl Benzoic acid Asreported | 1642-81-5 | 50g | $432 | 2026-06-03 | Buy |
4-(Chloromethyl)benzoic acid Chemical Properties, Uses, Production
Chemical Properties
White to slightly yellow crystalline powder
Uses
4-(Chloromethyl)benzoic acid was used for the synthesis of dihydroxy stilbene derivatives.
Uses
4-(Chloromethyl)benzoic acid was used in the synthesis of dihydroxy stilbene derivatives.
Synthesis
258278-55-6
1642-81-5
Example 1: Synthesis of 4-nitro-oxo-methyl-benzoic acid (I) a) Nitration of 4-chloromethyl-benzoic acid (III) 49.29 kg of 4-chloromethyl-benzoic acid (III) was dissolved in 92.9 L of acetonitrile and stirred for 20 minutes while a slow stream of nitrogen was passed. Subsequently, 93 mL of sulfuric acid was added and stirring was continued for 15 minutes. Under the same operating conditions, 13.65 kg of silver nitrate was slowly added. The reactor was protected from light and the reaction mixture was stirred for 15 minutes. After that, the mixture was heated to reflux for 7 hours and 15 minutes. After completion of the reaction, it was cooled to 20°C-25°C. b) Post-treatment 37.2 L of dimethylformamide (DMF) was added and stirred for 30 min, maintaining the temperature between 20°C-25°C. The silver salt was separated by filtration under nitrogen pressure through a filter pre-washed with 11 L of water and containing 9 kg of filter media. The filter cake was washed with 28 L DMF in three passes. The solid waste was washed twice with 9.3 L DMF. The cellulose in the filter was removed and washed with DMF until clarified, then rinsed with water. c) Precipitation and purification The liquid phase was combined and stabilized at a temperature between 20°C and 25°C. Slowly add 1486 L of water over a period of 1 hour, maintaining the temperature between 20°C-25°C. Continue stirring for 1 hour, maintaining the same temperature range. The precipitate was separated by filtration and the filter cake was washed with water until the pH of the eluate was similar to that of water. Finally, the filter cake was washed with 18.6 L of ethanol. The wet solid was dried under vacuum at not more than 40 °C until the moisture content (KF method) was ≤ 0.2%. 9.68 kg of 4-nitro-oxo-methyl-benzoic acid (I) was obtained in 90.2% yield, 99.35% HPLC purity, and 0.23% (IV).
References
[1] Patent: WO2011/58162, 2011, A1. Location in patent: Page/Page column 7-8
4-(Chloromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| changzhoubaotuobiochemical&pharm、LTD. | 0519-13912326059 13912326059 | alona1979@163.com | China | 45 | 58 |
| Anhui Enbang Biological Technology Co., Ltd. | 0551-68936860-8515 15357955825 | 15357955825@163.com | China | 82 | 55 |
| Weifang Weimeng Chemical Co., Ltd. | QQ 1340191485 15105445095 | weimengchem@163.com | China | 482 | 58 |
| Suqian Gaosai Biomedical Technology Co., Ltd | 15250728346 | 465418843@qq.com | China | 29 | 58 |
| Shandong Elito Biotechnology Co., Ltd | 0539-18853986-090 13053958157 | 332554317@qq.com | China | 104 | 58 |
| Nanjing hongshenghuo Biotechnology Co., Ltd | 025-58311670 18020159086 | 54604129@qq.com | China | 185 | 58 |
| Jiangsu Greature Bio-Medicine Co., Ltd. | 0512-85557988 18662338937 | frank.wang@greature.com.cn | China | 145 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
View Latest Price from 4-(Chloromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 4- (Chloromethyl) Benzoic Acid
1642-81-5
|
$1.90 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 4-(Chloromethyl)benzoic acid
1642-81-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2021-07-13 | 4-(Chloromethyl)benzoic acid
1642-81-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4- (Chloromethyl) Benzoic Acid
1642-81-5
- $1.90
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-(Chloromethyl)benzoic acid
1642-81-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-(Chloromethyl)benzoic acid
1642-81-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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