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4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID structure

CAS No.: 725-14-4

Chemical Name:: 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

Synonyms: AKOS BAR-0018;RARECHEM AL BE 1217;CHEMBRDG-BB 5555852;4-(4-METHOXYPHENYL)BENZOIC ACID;4'-Methoxy-4-biphenylcarboxylicacid;4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID;4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID;4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-;4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid

CBNumber:: CB1743568

Molecular Formula:: C14H12O3

Molecular Weight:: 228.24

MDL Number:: MFCD00185792

MOL File:: 725-14-4.mol

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
4-(4-Methoxyphenyl)benzoicacid	M329528	100mg	$45
4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid >95%	045780	1g	$50
4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid	3565CH	1g	$77
4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid >95%	045780	500mg	$35
4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid	3565CH	25g	$284
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4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Properties

Melting point	253-256°
Boiling point	406.4±38.0 °C(Predicted)
Density	1.193±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Sealed in dry,Room Temperature
form	solid
pka	4.28±0.10(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	725-14-4(CAS DataBase Reference)
UNSPSC Code	12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

HazardClass

IRRITANT

NFPA 704

	0
2		0

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M329528	4-(4-Methoxyphenyl)benzoicacid	725-14-4	100mg	$45	2021-12-16	Buy
Matrix Scientific	045780	4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid >95%	725-14-4	1g	$50	2021-12-16	Buy
AK Scientific	3565CH	4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid	725-14-4	1g	$77	2021-12-16	Buy
Matrix Scientific	045780	4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid >95%	725-14-4	500mg	$35	2021-12-16	Buy
AK Scientific	3565CH	4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid	725-14-4	25g	$284	2021-12-16	Buy

Product number	Packaging	Price	Buy
M329528	100mg	$45	Buy
045780	1g	$50	Buy
3565CH	1g	$77	Buy
045780	500mg	$35	Buy
3565CH	25g	$284	Buy

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Uses,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1648, 1946 DOI: 10.1021/ja01212a086

Synthesis

619-58-9

5720-07-0

725-14-4

A reaction mixture was prepared using 4-methoxyphenylboronic acid (1 g, 6.58 mmol) and 4-iodobenzoic acid (1.63 g, 6.58 mmol) as raw materials and cesium carbonate (5.36 g, 16.45 mmol) as base in a 3:1 solvent mixture of 1,2-dimethoxyethane/water. The reaction system was degassed with nitrogen for 15 min and then tetrakis(triphenylphosphine)palladium (380 mg, 0.329 mmol) was added as catalyst. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, it was cooled to room temperature and acidified with 2M hydrochloric acid to pH<7, at which point a precipitate was generated. The precipitate was collected by filtration and the filtrate was extracted twice with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered through diatomaceous earth and concentrated under reduced pressure to give 1.50 g of 4'-methoxybiphenyl-4-carboxylic acid in 95% yield. The product was characterized by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6) with the following data: 1H NMR (DMSO-d6): δ 7.99 (d, J = 8.4 Hz, 2H), 7.74 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 3.80 (d, J = 8.7 Hz, 3.80 (d, J = 8.7 Hz, 2H), 4.50g of 4'-methoxybiphenyl-4-carboxylic acid. 2H), 3.80 (s, 3H); 13C NMR (DMSO-d6): δ 167.17, 159.49, 143.90, 131.16, 129.91, 128.77, 128.09, 126.08, 114.45, 55.17.

References

[1] Russian Chemical Bulletin, 2007, vol. 56, # 2, p. 369 - 370
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2009/146013, 2009, A1. Location in patent: Page/Page column 52
[4] Green Chemistry, 2009, vol. 11, # 12, p. 1929 - 1932
[5] Tetrahedron, 2012, vol. 68, # 32, p. 6517 - 6520

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

METHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE 4-Iodobenzoic acid 1,4-Dioxane Coumalic acid

4-Bromobenzoic acid 4-Ethynylanisole 1-(4'-METHOXY-BIPHENYL-4-YL)-ETHANONE 4-Methoxyphenylboronic acid Sodium sulfite

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Preparation Products

METHYL 4'-HYDROXY[1,1'-BIPHENYL]-4-CARBOXYLATE

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Suppliers

Global( 78)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	6085	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53900	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32343	55

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
Hebei Chuanghai Biotechnology Co., Ltd	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Amadis Chemical Company Limited	58
Mainchem Co., Ltd.	55

View Lastest Price from 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	4'-Methoxy-4-biphenylcarboxylic acid 725-14-4	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

4'-Methoxy-4-biphenylcarboxylic acid
725-14-4
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Spectrum

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID(725-14-4)¹HNMR

725-14-4(4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID)Related Search:

4-N-PROPYLOXYBIPHENYL-4'-CARBOXYLIC ACID 4-N-OCTYLOXYBIPHENYL-4'-CARBOXYLIC ACID Biphenyl 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID (R)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE

4'-(NONYLOXY)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4-ETHOXY-4'-BIPHENYLCARBOXYLIC ACID 3'-FLUORO-4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE METHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE

4-(PENTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEXYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEPTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4'-N-DECYLOXYBIPHENYL-4-CARBOXYLIC ACID (S)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE

4-BUTOXY-4'-BIPHENYLCARBOXYLIC ACID 4'-ACETOXY-BIPHENYL-4-CARBOXYLIC ACID 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

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CHEMBRDG-BB 5555852 4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID 4-(4-METHOXYPHENYL)BENZOIC ACID AKOS BAR-0018 [1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 4'-METHOXY- RARECHEM AL BE 1217 4'-Methoxy-4-biphenylcarboxylicacid 4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid 1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy- 4′-Methoxybiphenyl-4-carboxylic acid, CAS 725-14-4 725-14-4 pharmacetical