Hymexazol
- CAS No.
- 10004-44-1
- Chemical Name:
- Hymexazol
- Synonyms
- HYMEXAZOLE;5-METHYLISOXAZOL-3-OL;5-Methylisoxazol-3(2H)-one;3-HYDROXY-5-METHYLISOXAZOLE;TACHIGALOZE;HYDROXYISOXAZOLE;5-Hydroxy-3-methylisoxazole;bucid;f-319;T 319
- CBNumber:
- CB1754230
- Molecular Formula:
- C4H5NO2
- Molecular Weight:
- 99.09
- MDL Number:
- MFCD00144468
- MOL File:
- 10004-44-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 80°C |
|---|---|
| Boiling point | 185.54°C (rough estimate) |
| Density | 1.2992 (rough estimate) |
| vapor pressure | 0.182 Pa (25 °C) |
| refractive index | 1.4170 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in alcohol, acetone, THF, chloroform |
| form | Powder |
| pka | 5.91 (weak acid) |
| Water Solubility | 65,100 mg l-1 (20 °C) |
| color | White to Orange |
| Sensitive | Light Sensitive |
| Merck | 14,4856 |
| Henry's Law Constant | 4.7×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| InChI | 1S/C4H5NO2/c1-3-2-4(6)5-7-3/h2H,1H3,(H,5,6) |
| InChIKey | KGVPNLBXJKTABS-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)NO1 |
| CAS DataBase Reference | 10004-44-1(CAS DataBase Reference) |
| EWG's Food Scores | 1-2 |
| FDA UNII | 20T2M875LO |
| EPA Substance Registry System | Hymexazol (10004-44-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318-H361d-H411 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41-52/53 | |||||||||
| Safety Statements | 26-39-61 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NY2932000 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Eye Dam. 1 Repr. 2 Skin Sens. 1 |
|||||||||
| Toxicity | LD50 in male, female mice, rats (mg/kg): 2148, 1968, 4678, 3909 orally; 1297, 1167, 1924, 1884 s.c.; 445, 514, >1000, >1000 i.v.; in rats, rabbits (mg/kg): >10000, >2000 dermally (Nakamura, 1978) | |||||||||
| NFPA 704 |
|
Hymexazol price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H3275 | 3-Hydroxy-5-methylisoxazole ≥90% | 10004-44-1 | 50mg | $144 | 2026-04-30 | Buy |
| Sigma-Aldrich | H3275 | 3-Hydroxy-5-methylisoxazole ≥90% | 10004-44-1 | 250mg | $494 | 2026-04-30 | Buy |
| TCI Chemical | H1348 | 3-Hydroxy-5-methylisoxazole >98.0%(GC) | 10004-44-1 | 5g | $38 | 2026-04-30 | Buy |
| TCI Chemical | H1348 | 3-Hydroxy-5-methylisoxazole >98.0%(GC) | 10004-44-1 | 25g | $123 | 2026-04-30 | Buy |
| Usbiological | H9110-14P | 3-Hydroxy-5-methylisoxazole | 250mg | $403 | 2026-06-03 | Buy |
Hymexazol Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
Pesticide.
Uses
Agricultural fungicide and plant growth regulator.
Uses
Hymexazol is used to control soil-borne diseases caused by Fusarium, Aphanomyces, Pythium, Corficium and Typhula spp. in rice, sugar beet, fodder beet, vegetables, cucurbits, ornamentals, carnations and forest tree seedlings. It is also used as a seed dressing and stimulates some plant growth.
Definition
ChEBI: A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals.
Production Methods
Hymexazol is synthesised through a water-phase process that begins with the reaction of hydroxylamine salts, typically hydroxylamine sulphate or hydrochloride, with methyl or ethyl acetoacetate to form a hydroxamic acid intermediate. This intermediate undergoes ring closure to form the oxazole ring, which is central to hymexazol’s structure. The reaction mixture is then acidified using hydrochloric acid to stabilize the product, followed by extraction with an organic solvent such as chloroform. The crude product is isolated through precipitation and centrifugation, and finally dried to yield hymexazol with an active content typically between 95% and 98%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 4307, 1983 DOI: 10.1021/jo00171a030
Mechanism of action
Hymexazol works by inhibiting RNA synthesis in pathogenic fungi, disrupting their growth and reproduction.
Metabolic pathway
Degradation of hymexazol in soil gave acetoacetamide and the product of rearrangement, 5-methyl-2(3H)-oxazolone.H owever, in plants the fungicide was principally converted into its O- and N-glucoside conjugates in the roots and shoots. The two main metabolites of hymexazol found in the urine of rats were the O-glucuronide and sulfate conjugates.
Degradation
Hymexazol is stable under alkaline conditions and relatively stable in acidic conditions. It is stable to sunlight and heat (PM). It should be noted that the parent molecule is tautomeric. Hymexazol is highly volatile and will be lost by volatilisation unless it is covered or incorporated into soil. The fungicide was completely biodegraded in natural water at 30 °C in 2 weeks and at 10-13 °C in 2 months (Rebenok and Kolesnikova, 1983). Hymexazol is stable in sunlight but it is readily degraded by ultraviolet light. Photolysis of an aqueous solution of the fungicide at 253.7 nm, using a low pressure Hg lamp, afforded the oxazolinone (2) as the major product and at least two unidentified minor components. The oxazolinone (2) has been found in soil studies as described below and is a product of rearrangement formed via an aziridinone intermediate as shown in Scheme 1 (Nakagawa et al., 1974).
Pesticide Type
Fungicide
Hymexazol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Huirun Pharmaceutical Co., Ltd | 15715295967; 15715295967 | 3934839128@qq.com | China | 170 | 58 |
| Hubei ZhengXingyuan Chemical Co., Ltd. | 18674046631 18707110115 | 2905723734@qq.com | China | 287 | 58 |
| Henan Yanyuan Biotechnology Co., Ltd | 18637186683 | 2392060329@qq.com | China | 36 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Hymexazol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Hymexazol
10004-44-1
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-17 | Hymexazol
10004-44-1
|
1KG | ≥98% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-14 | hymexazol
10004-44-1
|
100KG | 98 | 200TONS | Qingdao Trust Agri Chemical Co.,Ltd |
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