1-Deoxymannojirimycin hydrochloride
- CAS No.
- 73465-43-7
- Chemical Name:
- 1-Deoxymannojirimycin hydrochloride
- Synonyms
- DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride;1-Deoxymannojirimycin hydrochloride
- CBNumber:
- CB1768822
- Molecular Formula:
- C6H14ClNO4
- Molecular Weight:
- 199.63
- MDL Number:
- MFCD00083611
- MOL File:
- 73465-43-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 183-185°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: soluble10mg/mL |
| form | Powder |
| color | white to off-white |
| Water Solubility | Soluble in water (50 mM) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
| InChI | 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1 |
| InChIKey | ZJIHMALTJRDNQI-MVNLRXSJSA-N |
| SMILES | Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O |
| CAS DataBase Reference | 73465-43-7 |
| UNSPSC Code | 51102829 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2941900000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
|||||||||
| NFPA 704 |
|
1-Deoxymannojirimycin hydrochloride price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D9160 | 1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 1mg | $158 | 2026-04-30 | Buy |
| Sigma-Aldrich | D9160 | 1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 5mg | $422 | 2026-04-30 | Buy |
| Cayman Chemical | 17178 | 1-Deoxymannojirimycin (hydrochloride) ≥98% | 73465-43-7 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 17178 | 1-Deoxymannojirimycin (hydrochloride) ≥98% | 73465-43-7 | 5mg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 17178 | 1-Deoxymannojirimycin (hydrochloride) ≥98% | 73465-43-7 | 10mg | $139 | 2026-04-30 | Buy |
1-Deoxymannojirimycin hydrochloride Chemical Properties, Uses, Production
Description
1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.
Chemical Properties
White Crystalline Solid
Uses
Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.
Uses
Selective inhibitor of a-mannosidase
storage
+4°C
References
[1] J BISCHOFF R K L Liscum. The use of 1-deoxymannojirimycin to evaluate the role of various alpha-mannosidases in oligosaccharide processing in intact cells.[J]. The Journal of Biological Chemistry, 1986, 261 10: 4766-4774.
[2] JOYCE BISCHOFF Rosalind K. The effect of 1-deoxymannojirimycin on rat liver α-mannosidases[J]. Biochemical and biophysical research communications, 1984, 125 1: Pages 324-331. DOI:10.1016/s0006-291x(84)80371-x
[3] ULRIKE FUHRMANN. Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides[J]. Nature, 1984, 307 5953: 755-758. DOI:10.1038/307755a0
[4] KUNIO MIYAKE Kaoru N. Inhibition of α-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death[J]. Neurotoxicology, 2009, 30 1: Pages 144-150. DOI:10.1016/j.neuro.2008.10.010
[5] APRIL TAI. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells.[J]. Journal of Biological Engineering, 2011, 5 1: 1. DOI:10.1186/1754-1611-5-1
[6] CHI-LIN LEE. Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination[J]. Biotechnology and Bioengineering, 2011, 109 6: 1551-1560. DOI:10.1002/bit.24413
1-Deoxymannojirimycin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-Deoxymannojirimycin hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from 1-Deoxymannojirimycin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 1-DeoxyMannojiriMycin hydrochloride
73465-43-7
|
10G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-27 | 1-Deoxymannojirimycin hydrochloride
73465-43-7
|
$98.00-456.00 | 10g | TargetMol Chemicals Inc. |
-
- 1-DeoxyMannojiriMycin hydrochloride
73465-43-7
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-Deoxymannojirimycin hydrochloride
73465-43-7
- $98.00-456.00
- TargetMol Chemicals Inc.
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