SKF 96365 hydrochloride
- CAS No.
- 130495-35-1
- Chemical Name:
- SKF 96365 hydrochloride
- Synonyms
- CS-2170;SKF 96365;SKF 96365 HCI;SKF-96365, HC;SKF-96365, HCl;SK AND F 96365;SKF-96365;SKF 96365;SKF 96365 hydrochlor;SKF 96365 hydrochloride;SKF 96365, TRP channel blocker
- CBNumber:
- CB7752278
- Molecular Formula:
- C22H27ClN2O3
- Molecular Weight:
- 402.91
- MDL Number:
- MFCD00236407
- MOL File:
- 130495-35-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 119 °C |
|---|---|
| RTECS | NI6823500 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: >20 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble to 100mM in water |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H |
| InChIKey | FWLPKVQUECFKSW-UHFFFAOYSA-N |
| SMILES | Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1 |
| CAS DataBase Reference | 130495-35-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 33BI32858P |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.29.4300 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
SKF 96365 hydrochloride price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7809 | SKF-96365 ≥98% (HPLC), solid | 130495-35-1 | 5mg | $236 | 2026-04-30 | Buy |
| Sigma-Aldrich | 567310-M | SKF-96365, Hydrochloride Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. | 130495-35-1 | 5 mg | $177 | 2026-04-30 | Buy |
| Sigma-Aldrich | 567310-M | SKF-96365, Hydrochloride Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. | 130495-35-1 | 1 unit | $165 | 2025-07-31 | Buy |
| TCI Chemical | K0066 | SKF-96365 | 130495-35-1 | 10MG | $229 | 2026-04-30 | Buy |
| TCI Chemical | K0066 | SKF-96365 | 130495-35-1 | 50MG | $376 | 2026-04-30 | Buy |
SKF 96365 hydrochloride Chemical Properties, Uses, Production
Description
SKF-96365 (130495-35-1) is an inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but not ATP-gated Ca2+ entry.1 It has also been shown to block transient receptor potential canonical type (TRPC) channels2, high-voltage-activated (HVA) L-type channels1, K channels3, sarcoplasmic reticulum Ca-ATPase4 and voltage-gated sodium channels5. SKF-96365 is a potent blocker of LVA T-type Ca channels, in particular Ca(V)3.1 (IC50 = 0.56 μM).6
Uses
SKF 96365 Hydrochloride is a novel inhibitor of receptor-mediated calcium entry.
Definition
ChEBI: SKF-96365 hydrochloride is the hydrochloride salt of SKF-96365. It is a TRP channel blocker. It has a role as a TRP channel blocker, an apoptosis inducer, an autophagy inducer, a GABA antagonist, an antineoplastic agent, a calcium channel blocker and a platelet aggregation inhibitor. It contains a SKF-96365 free base(1+).
General Description
Inhibits receptor-mediated Ca2+ entry in stimulated platelets (IC50 = 8-12 μM in intact platelets), neutrophils, and endothelial cells (IC50 = 30 μM for human endothelial cells) at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
Biological Activity
Store-operated Ca 2+ entry (SOCE) inhibitor that inhibits STIM1. Also inhibits TRP channels, voltage-gated Ca 2+ channels and potassium channels.
Biochem/physiol Actions
SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+entry and voltage-gated Ca2+entry . SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization. It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression. SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.
storage
Store at RT
References
[1] J E MERRITT. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.[J]. Biochemical Journal, 1990, 271 2: 515-522. DOI:10.1042/bj2710515
[2] KIRILL KISELYOV. Functional interaction between InsP3 receptors and store-operated Htrp3 channels[J]. Nature, 1998, 396 6710: 478-482. DOI:10.1038/24890
[3] G. SCHWARZ B. N G Droogmans. Multiple effects of SK&F 96365 on ionic currents and intracellular calcium in human endothelial cells[J]. Cell calcium, 1994, 15 1: Pages 45-54. DOI:10.1016/0143-4160(94)90103-1
[4] M J MASON L J H B Mayer. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365.[J]. American Journal of Physiology, 1993, 264 3 Pt 1: C654-62. DOI:10.1152/ajpcell.1993.264.3.c654
[5] S. J. HONG C che C Wan Wan Lin. Inhibition of the Sodium Channel by SK&F 96365, an Inhibitor of the Receptor-Operated Calcium Channel, in Mouse Diaphragm.[J]. Journal of Biomedical Science, 1994, 3 1: 172-178. DOI:10.1007/bf02253347
[6] A SINGH. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels[J]. British Journal of Pharmacology, 2010, 160 6: 1464-1475. DOI:10.1111/j.1476-5381.2010.00786.x
SKF 96365 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Supplier | Advantage |
|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Ascent Scientific | 60 |
| Dalian Meilun Biotech Co., Ltd. | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 80 |
| TCI Europe | 75 |
| TCI AMERICA | 75 |
| MedChemexpress LLC | 58 |
| Bide Pharmatech Ltd. | 60 |
| Sigma-Aldrich | 80 |
View Latest Price from SKF 96365 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | SKF-96365 hydrochloride
130495-35-1
|
$52.00-141.00 | 99.90% | 10g | TargetMol Chemicals Inc. |
-
- SKF-96365 hydrochloride
130495-35-1
- $52.00-141.00
- 99.90%
- TargetMol Chemicals Inc.
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