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(S)-BI 665915

(S)-BI 665915 Structure
(S)-BI 665915 structure
CAS No.
1360550-05-5
Chemical Name:
(S)-BI 665915
Synonyms
(S)-BI 665915;(S) BI 665915,(S)BI 665915;1H-Pyrazole-1-acetamide, 4-[3-[(1S)-1-[4-(2-amino-5-pyrimidinyl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-N,N-dimethyl-
CBNumber:
CB18054530
Molecular Formula:
C24H26N8O2
Molecular Weight:
458.52
MDL Number:
MFCD32664445
MOL File:
1360550-05-5.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
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(S)-BI 665915 Properties

Boiling point 738.8±70.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
pka 3.15±0.10(Predicted)

(S)-BI 665915 Chemical Properties, Uses, Production

Uses

(S)-BI 665915 is an orally active oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.7 nM for FLAP binding. (S)-BI 665915 inhibits FLAP functional in human whole blood with an IC50 of 45 nM. (S)-BI 665915 demonstrates an excellent cross-species agent metabolism and pharmacokinetics (DMPK) profile and a dose-dependent inhibition of LTB4 production[1].

in vivo

(S)-BI 665915 (oral; 1-100 mg/kg) demonstrates dose-dependent LTB4 production inhibition in mouse whole blood, 2 h after single oral dose[1].
(S)-BI 665915 (iv of 1 mg/kg or po of 10 mg/kg) shows low iv plasma clearance in all three species, with clearance values of 7 % Qh in rat, 2.8 % Qh in dog, and 3.6 % Qh in cynomolgus monkey, respectively. The volume of distribution (Vss) across species tested is in a range of 0.5 to 1.2 L/kg, and the bioavailability was good (45 to 63 %) in all species tested[1].

Animal Model:C57BL/6 mice[1]
Dosage:1, 3, 10, 30, 100 mg/kg (Pharmacokinetic Analysis)
Administration:Oral
Result:Demonstrated dose-dependent LTB4 production inhibition in mouse whole blood, 2 h after single oral dose.
Animal Model:Rat; dog; cynomolgus monkey[1]
Dosage:1 mg/kg (iv) or 10 mg/kg (po)
Administration:Iv or po
Result:Showed low iv plasma clearance in all three species, with clearance values of 7 % Qh in rat, 2.8 % Qh in dog, and 3.6 % Qh in cynomolgus monkey, respectively.

References

[1] Takahashi H, et al. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem. 2015 Feb 26;58(4):1669-90. DOI:10.1021/jm501185j

(S)-BI 665915 Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-BI 665915 Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
BOC Sciences 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from (S)-BI 665915 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-BI 665915 pictures 2026-04-20 (S)-BI 665915
1360550-05-5
 $1970.00-3400.00 10g TargetMol Chemicals Inc.
(S)-BI 665915 pictures 2025-07-26 (S)-BI 665915
1360550-05-5
 $1970.00-3400.00 10g TargetMol Chemicals Inc.
  • (S)-BI 665915 pictures
  • (S)-BI 665915
    1360550-05-5
  • $1970.00-3400.00
  • TargetMol Chemicals Inc.
  • (S)-BI 665915 pictures
  • (S)-BI 665915
    1360550-05-5
  • $1970.00-3400.00
  • TargetMol Chemicals Inc.

1360550-05-5 ((S)-BI 665915) Related Search:

(S)-BI 665915 2-[4-[3-[(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]pyrazol-1-yl]-N,N-dimethylacetamide GSK2190915 10H-Pyridazino[1′,6′:4,5]pyrazino[2,1-c][1,4]oxazine-3,5-dione, 2-[(1S)-1-(1-chloro-2-naphthalenyl)ethoxy]-7,8,10a,11-tetrahydro-4-hydroxy-, (10aS)- Benzenebutanoic acid, 2,6-dichloro-α,γ-dioxo-
2(3H)-Furanone, 3-[(2,4-dihydroxyphenyl)methylene]-5-(4-methoxyphenyl)-

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(S)-BI 665915 (S) BI 665915,(S)BI 665915 1H-Pyrazole-1-acetamide, 4-[3-[(1S)-1-[4-(2-amino-5-pyrimidinyl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-N,N-dimethyl- 1360550-05-5