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Mal-PEG8-Val-Cit-PAB-MMAE

Mal-PEG8-Val-Cit-PAB-MMAE structure

CAS No.: 2353409-69-3

Chemical Name:: Mal-PEG8-Val-Cit-PAB-MMAE

Synonyms: Mal-PEG8-Val-Cit-PAB-MMAE;4-((29S,32S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-29-isopropyl-27,30-dioxo-32-(3-ureidopropyl)-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl ((2S)-1-(((2S)-1-(((4R,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate

CBNumber:: CB18054752

Molecular Formula:: C81H131N11O23

Molecular Weight:: 1626.97

MDL Number:: MFCD32669864

MOL File:: 2353409-69-3.mol

MSDS File:: SDS

Last updated:2026-05-27 23:45:07

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Mal-PEG8-Val-Cit-PAB-MMAE Properties

Boiling point	1438.4±65.0 °C(Predicted)
Density	1.191±0.06 g/cm3(Predicted)
pka	13.29±0.70(Predicted)
form	Solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Mal-PEG8-Val-Cit-PAB-MMAE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
BroadPharm	bp-24252	Mal-PEG8-Val-Cit-PAB-MMAE 98%	2353409-69-3	1MG	$280	2026-05-24	Buy
BroadPharm	bp-24252	Mal-PEG8-Val-Cit-PAB-MMAE 98%	2353409-69-3	5MG	$450	2026-05-24	Buy
BroadPharm	bp-24252	Mal-PEG8-Val-Cit-PAB-MMAE 98%	2353409-69-3	10MG	$720	2026-05-24	Buy
BroadPharm	bp-24252	Mal-PEG8-Val-Cit-PAB-MMAE 98%	2353409-69-3	25MG	$1450	2026-05-24	Buy
aablocks	AA01V4NU	Mal-PEG8-Val-Cit-PAB-MMAE 99%	2353409-69-3	5mg	$122	2026-05-31	Buy

Product number	Packaging	Price	Buy
bp-24252	1MG	$280	Buy
bp-24252	5MG	$450	Buy
bp-24252	10MG	$720	Buy
bp-24252	25MG	$1450	Buy
AA01V4NU	5mg	$122	Buy

Mal-PEG8-Val-Cit-PAB-MMAE Chemical Properties, Uses, Production

Description

Mal-PEG8-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a maleimide PEG8 moiety, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Mal is reactive with thiol group of antibody.

Uses

Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)[1].

IC 50

Auristatin

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Mal-PEG8-Val-Cit-PAB-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

Mal-PEG8-Val-Cit-PAB-MMAE Suppliers

Global Suppliers ( 19)

Supplier	Tel	Email	Country	ProdList	Advantage
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4229	58
Abydos Scientific	18936879710 18851749494	sales@abydoscientific.com	China	1000	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Shanghai Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	811	58
Nanchang Tianzhen Biotechnology Co., Ltd	13758194781 13173652190	522013271@qq.com	China	2447	58
Hubei wei shi reagent group ltd., company	027-59102966 18717199209	2853877583@qq.com	China	2896	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80514535 19917294565	et@chemextension.com	China	5061	58
Shanxi Nuocheng Biotechnology Co., Ltd	17835231871	572710841@qq.com	China	7931	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	38904	58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd.	hanfangpharma@126.com 15165037910	hanfangpharma@126.com	China	25800	58

Supplier	Advantage
Xi'an Confluore Biological Technology Co., Ltd.	58
Abydos Scientific	58
TargetMol Chemicals Inc.	58
Shanghai Haoyuan Chemexpress Co., Ltd.	58
Nanchang Tianzhen Biotechnology Co., Ltd	58
Hubei wei shi reagent group ltd., company	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	58
Shanxi Nuocheng Biotechnology Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd.	58

View Latest Price from Mal-PEG8-Val-Cit-PAB-MMAE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-07	Mal-PEG8-Val-Cit-PAB-MMAE 2353409-69-3		5mg	>98.00%	5mg	Xian confluore Biological Technology Co., Ltd.

Mal-PEG8-Val-Cit-PAB-MMAE
2353409-69-3
$0.00
>98.00%
Xian confluore Biological Technology Co., Ltd.

2353409-69-3 (Mal-PEG8-Val-Cit-PAB-MMAE) Related Search:

Fmoc-VAP-MMAE L-Valinamide, N-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-alanyl-L-alanyl-L-asparaginyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1... (Aminooxy)acetamide-Val-Cit-PAB-MMAE DBCO-PEG4-Val-Cit-PAB-MMAF Aminocaproyl-Val-Cit-PABC-MMAE

Mal-PEG8-Val-Cit-PAB-MMAE

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Mal-PEG8-Val-Cit-PAB-MMAE 4-((29S,32S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-29-isopropyl-27,30-dioxo-32-(3-ureidopropyl)-3,6,9,12,15,18,21,24-octaoxa-28,31-diazatritriacontan-33-amido)benzyl ((2S)-1-(((2S)-1-(((4R,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate 2353409-69-3 ADC LINKER