| Chemical Properties | Back Directory | [Boiling point ]
1438.4±65.0 °C(Predicted) | [density ]
1.191±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.29±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mal-PEG8-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a maleimide PEG8 moiety, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Mal is reactive with thiol group of antibody. | [Uses]
Mal-PEG8-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162)[1]. | [IC 50]
Auristatin | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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| Company Name: |
Abydos Scientific
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| Tel: |
025-84767922 18936879710 |
| Website: |
http://www.abydoscientific.com/index.html |
| Company Name: |
YJ Pharma
|
| Tel: |
13962794339 |
| Website: |
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| Company Name: |
YantaiBio
|
| Tel: |
13758194781 |
| Website: |
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